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Database: UniProt
Entry: I0GH90_CALEA
LinkDB: I0GH90_CALEA
Original site: I0GH90_CALEA 
ID   I0GH90_CALEA            Unreviewed;       434 AA.
AC   I0GH90;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   05-JUL-2017, entry version 40.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:BAL80127.1};
GN   OrderedLocusNames=CSE_00010 {ECO:0000313|EMBL:BAL80127.1};
OS   Caldisericum exile (strain DSM 21853 / NBRC 104410 / AZM16c01).
OC   Bacteria; Caldiserica; Caldisericia; Caldisericales; Caldisericaceae;
OC   Caldisericum.
OX   NCBI_TaxID=511051 {ECO:0000313|EMBL:BAL80127.1, ECO:0000313|Proteomes:UP000004793};
RN   [1] {ECO:0000313|EMBL:BAL80127.1, ECO:0000313|Proteomes:UP000004793}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 21853 / NBRC 104410 / AZM16c01
RC   {ECO:0000313|Proteomes:UP000004793};
RA   Narita-Yamada S., Kawakoshi A., Nakamura S., Sasagawa M., Fukada J.,
RA   Sekine M., Kato Y., Fukai R., Sasaki K., Hanamaki A., Narita H.,
RA   Konno Y., Mori K., Yamazaki S., Suzuki K., Fujita N.;
RT   "Whole genome sequence of Caldisericum exile AZM16c01.";
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; AP012051; BAL80127.1; -; Genomic_DNA.
DR   RefSeq; WP_014452538.1; NC_017096.1.
DR   EnsemblBacteria; BAL80127; BAL80127; CSE_00010.
DR   KEGG; cex:CSE_00010; -.
DR   PATRIC; fig|511051.3.peg.1; -.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000004793; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000004793};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000004793}.
FT   DOMAIN      126    259       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      342    411       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     134    141       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   434 AA;  49404 MW;  B90292F6390B77BE CRC64;
     MNTWEKVLEQ LKEILSVPAF ETFIRPVEFV SESDSEIILK APSTFVKEML ETKYASLVNA
     TLQEVSGKSI LLNIIVEEKK PKTPPVIIVN NITLNKDFTF EEFVVGSGNR LSYAAAKAVA
     SNPGKVYNPL YIYGKVGLGK THLLHAIGHE LIRNFKDIKI IYTTAEKFTN EVIFAIQNAQ
     SNSDLIDRFH KKYRTTDVLL IDDIQFLVGK ERTQEEFFHT FNALHETGKQ IVITSDVPPK
     ELATLEERLR SRFEWGLITD IQPPDYETRI AILKKKAQKE NITISDEVLA YIANNIFSNI
     RELEGALIRL VAKASLLNEN ITVEFAKNAL SDIIKQTSEP ITVDRIKKVV ANYFNVDVES
     LSDKRRTQNI VLPRQIAMYL TREFTDLSLP QIGDAFGGRD HTTVMHAYAK IKEEVKKTET
     MRALVDEIIN RLKE
//
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