GenomeNet

Database: UniProt
Entry: I0GXF4_ACTM4
LinkDB: I0GXF4_ACTM4
Original site: I0GXF4_ACTM4 
ID   I0GXF4_ACTM4            Unreviewed;       413 AA.
AC   I0GXF4;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 61.
DE   RecName: Full=Cyclic dehypoxanthine futalosine synthase {ECO:0000256|HAMAP-Rule:MF_00992};
DE            Short=Cyclic DHFL synthase {ECO:0000256|HAMAP-Rule:MF_00992};
DE            EC=1.21.98.1 {ECO:0000256|HAMAP-Rule:MF_00992};
DE   AltName: Full=Dehypoxanthine futalosine cyclase {ECO:0000256|HAMAP-Rule:MF_00992};
DE            Short=DHFL cyclase {ECO:0000256|HAMAP-Rule:MF_00992};
DE   AltName: Full=Menaquinone biosynthetic enzyme MqnC {ECO:0000256|HAMAP-Rule:MF_00992};
GN   Name=mqnC {ECO:0000256|HAMAP-Rule:MF_00992};
GN   OrderedLocusNames=AMIS_2210 {ECO:0000313|EMBL:BAL85441.1};
OS   Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 /
OS   JCM 3121 / NBRC 102363 / NCIMB 12654 / NRRL B-3342 / UNCC 431).
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=512565 {ECO:0000313|EMBL:BAL85441.1, ECO:0000313|Proteomes:UP000007882};
RN   [1] {ECO:0000313|EMBL:BAL85441.1, ECO:0000313|Proteomes:UP000007882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NBRC 102363 /
RC   NCIMB 12654 / NRRL B-3342 / UNCC 431
RC   {ECO:0000313|Proteomes:UP000007882};
RA   Ohnishi Y., Ishikawa J., Sekine M., Hosoyama A., Harada T., Narita H.,
RA   Hata T., Konno Y., Tutikane K., Fujita N., Horinouchi S., Hayakawa M.;
RT   "Complete genome sequence of Actinoplanes missouriensis 431 (= NBRC
RT   102363).";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Radical SAM enzyme that catalyzes the cyclization of
CC       dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine
CC       (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
CC       {ECO:0000256|HAMAP-Rule:MF_00992}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-
CC         deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-
CC         methionine; Xref=Rhea:RHEA:33083, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17319, ChEBI:CHEBI:57844, ChEBI:CHEBI:58864,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64270; EC=1.21.98.1;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00992};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00992};
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.
CC       {ECO:0000256|HAMAP-Rule:MF_00992};
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_00992}.
CC   -!- SIMILARITY: Belongs to the radical SAM superfamily. MqnC family.
CC       {ECO:0000256|HAMAP-Rule:MF_00992}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP012319; BAL85441.1; -; Genomic_DNA.
DR   RefSeq; WP_014440341.1; NC_017093.1.
DR   AlphaFoldDB; I0GXF4; -.
DR   STRING; 512565.AMIS_2210; -.
DR   KEGG; ams:AMIS_2210; -.
DR   PATRIC; fig|512565.3.peg.226; -.
DR   eggNOG; COG1060; Bacteria.
DR   HOGENOM; CLU_040406_1_0_11; -.
DR   OMA; ATMMFGS; -.
DR   OrthoDB; 9802027at2; -.
DR   UniPathway; UPA00079; -.
DR   Proteomes; UP000007882; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0005506; F:iron ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0046992; F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond; IEA:UniProtKB-UniRule.
DR   GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR   GO; GO:0009234; P:menaquinone biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd01335; Radical_SAM; 1.
DR   Gene3D; 3.20.20.70; Aldolase class I; 1.
DR   HAMAP; MF_00992; MqnC; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR045567; CofH/MnqC-like_C.
DR   InterPro; IPR022431; Cyclic_DHFL_synthase_mqnC.
DR   InterPro; IPR034405; F420.
DR   InterPro; IPR020050; FO_synthase_su2.
DR   InterPro; IPR007197; rSAM.
DR   NCBIfam; TIGR00423; CofH family radical SAM protein; 1.
DR   NCBIfam; TIGR03699; menaquin_MqnC; 1.
DR   PANTHER; PTHR43076; FO SYNTHASE (COFH); 1.
DR   PANTHER; PTHR43076:SF1; LIPOYL SYNTHASE 2; 1.
DR   Pfam; PF19288; CofH_C; 1.
DR   Pfam; PF04055; Radical_SAM; 1.
DR   PIRSF; PIRSF004762; CHP00423; 2.
DR   SFLD; SFLDF00342; cyclic_dehypoxanthine_futalosi; 1.
DR   SFLD; SFLDG01064; F420__menaquinone_cofactor_bio; 1.
DR   SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR   PROSITE; PS51918; RADICAL_SAM; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485, ECO:0000256|HAMAP-Rule:MF_00992};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|HAMAP-Rule:MF_00992};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|HAMAP-
KW   Rule:MF_00992}; Menaquinone biosynthesis {ECO:0000256|HAMAP-Rule:MF_00992};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW   Rule:MF_00992}; Oxidoreductase {ECO:0000256|HAMAP-Rule:MF_00992};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007882};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, ECO:0000256|HAMAP-
KW   Rule:MF_00992}.
FT   DOMAIN          54..301
FT                   /note="Radical SAM core"
FT                   /evidence="ECO:0000259|PROSITE:PS51918"
FT   BINDING         68
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00992"
FT   BINDING         72
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00992"
FT   BINDING         75
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00992"
SQ   SEQUENCE   413 AA;  45430 MW;  0A8A8F8691D8D3F4 CRC64;
     MTANPEIDSI LQRGADGGRI TPEEALLLYT QAPFHALGEA ADAVRRRRYP DGIVTYLIDR
     NINYTNVCVT ACKFCAFFRA PKHKEGWSHP TEEILRRCGE AVDLGATQVM LQGGHHPDYG
     VAYYEDLFSS VKQAYPQLAI HSIGPSEILH MAKVDGVSIE EAVIRIKAAG LDSIAGAGAE
     MLPERPRKAI APLKESGERW LEVMAVAHRH GLSSTATMMM GTGETNAERI EHITMIRGVQ
     DLAVANGYRD DAVEKDHTVG GFRAFIPWTY QPENNHLKGR TQATTVEYLR FIAVSRLFFD
     NVAHLQASWL TTGKDIGQLS LHMGVDDLGS IMLEENVISS AGARHRSNLQ GLISMIRTAD
     RIPAQRDTWY RHLAVHRTAA EDPTDERVVS HFSSIAIKGG GAGRTQLPLV DAS
//
DBGET integrated database retrieval system