ID I0I301_CALAS Unreviewed; 407 AA.
AC I0I301;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Cystathionine gamma-lyase {ECO:0000313|EMBL:BAL99638.1};
GN Name=metC {ECO:0000313|EMBL:BAL99638.1};
GN OrderedLocusNames=CLDAP_15990 {ECO:0000313|EMBL:BAL99638.1};
OS Caldilinea aerophila (strain DSM 14535 / JCM 11387 / NBRC 104270 /
OS STL-6-O1).
OC Bacteria; Chloroflexota; Caldilineae; Caldilineales; Caldilineaceae;
OC Caldilinea.
OX NCBI_TaxID=926550 {ECO:0000313|EMBL:BAL99638.1, ECO:0000313|Proteomes:UP000007880};
RN [1] {ECO:0000313|EMBL:BAL99638.1, ECO:0000313|Proteomes:UP000007880}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14535 / JCM 11387 / NBRC 104270 / STL-6-O1
RC {ECO:0000313|Proteomes:UP000007880};
RA Oguchi A., Hosoyama A., Sekine M., Fukai R., Kato Y., Nakamura S.,
RA Hanada S., Yamazaki S., Fujita N.;
RT "Complete genome sequence of Caldilinea aerophila DSM 14535 (= NBRC
RT 102666).";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|RuleBase:RU362118}.
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DR EMBL; AP012337; BAL99638.1; -; Genomic_DNA.
DR RefSeq; WP_014432877.1; NC_017079.1.
DR AlphaFoldDB; I0I301; -.
DR STRING; 926550.CLDAP_15990; -.
DR KEGG; cap:CLDAP_15990; -.
DR PATRIC; fig|926550.5.peg.1793; -.
DR eggNOG; COG0626; Bacteria.
DR HOGENOM; CLU_018986_2_0_0; -.
DR OrthoDB; 9780685at2; -.
DR Proteomes; UP000007880; Chromosome.
DR GO; GO:0003962; F:cystathionine gamma-synthase activity; IEA:InterPro.
DR GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR044639; CGS1/2.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR43379; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR43379:SF1; CYSTATHIONINE GAMMA-SYNTHASE 1, CHLOROPLASTIC-RELATED; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:BAL99638.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000007880}.
FT MOD_RES 223
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 407 AA; 44849 MW; 9BA979EDDC68FEB0 CRC64;
MQQTQSSTDA IRSSTITSTQ AVHAGEQRFR SHHSLTVPIV QTAVYTFDTT EALIRYTEER
LFWNEPEREE YGRYGNPTVR ALEAKIAELE GAQDAIVVSS GMGAVTSTLL LLLQPGQHFI
LTDNCYLSTL EFCQNFLKRY GIECTLVPFG DYDAIEAAVC PQTRLIFSES PTNPFVRCLD
FERLVSIARC HHLLTVVDST FATPYNLRPL AFGVDLVIHS LTKYLAGHND AMAGVVAGRY
DLTTPLRQMQ GLLGNIAAPQ TAYLILRGIK TLALRMERQN ASGLAVARFL EGHPKVRRVW
YPFLESHPDY AVARATLRGG GGVVSFEIEG DAGRAHRFID ALRIPVIGPS LGGVESIVSP
LALMGYANLS PEERLALGIR DELVRLCIGI EDTENLIADL AQALDQI
//
