ID I0IWZ7_9HEPC Unreviewed; 300 AA.
AC I0IWZ7;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Polyprotein {ECO:0000313|EMBL:BAM09796.1};
DE Flags: Fragment;
OS Hepatitis C virus subtype 1b.
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Flasuviricetes;
OC Amarillovirales; Flaviviridae; Hepacivirus; Hepacivirus hominis.
OX NCBI_TaxID=31647 {ECO:0000313|EMBL:BAM09796.1};
RN [1] {ECO:0000313|EMBL:BAM09796.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MK051115 {ECO:0000313|EMBL:BAM09796.1};
RA Suzuki F., Sezaki H., Akuta N., Suzuki Y., Seko Y., Kawamura Y., Hosaka T.,
RA Kobayashi M., Saito S., Arase Y., Ikeda K., Kobayashi M., Mineta R.,
RA Watahiki S., Miyakawa Y., Kumada H.;
RT "Prevalence of hepatitis C virus variants resistant to NS3 protease
RT inhibitors or the NS5A inhibitor (BMS-790052) in hepatitis patients with
RT genotype 1b.";
RL J. Clin. Virol. 54:352-354(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}.
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DR EMBL; AB709404; BAM09796.1; -; Genomic_RNA.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0044423; C:virion component; IEA:UniProtKB-KW.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0019087; P:transformation of host cell by virus; IEA:InterPro.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0019062; P:virion attachment to host cell; IEA:UniProtKB-KW.
DR Gene3D; 2.40.10.120; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR004109; HepC_NS3_protease.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR Pfam; PF02907; Peptidase_S29; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51822; HV_PV_NS3_PRO; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Viral attachment to host cell {ECO:0000256|ARBA:ARBA00022804};
KW Viral RNA replication {ECO:0000256|ARBA:ARBA00022953};
KW Virion {ECO:0000256|ARBA:ARBA00022844};
KW Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296}.
FT DOMAIN 1..182
FT /note="Peptidase S29"
FT /evidence="ECO:0000259|PROSITE:PS51822"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAM09796.1"
FT NON_TER 300
FT /evidence="ECO:0000313|EMBL:BAM09796.1"
SQ SEQUENCE 300 AA; 31411 MW; A720F5286EE4307B CRC64;
RPSQAYSQQT RGLLGCIITS LTGRDKNQVE GEVQVVSTAT QTFLATCING VCWSVYHGAG
SKTLAGQKGP ITQMYTNVDL DLVGWQAPSG TRSLTPCTCG SSDLYLVTRH ADVIPVRRRG
DSRGSLLSPR PISYLKGSSG GPLLCPSGHA VGIFRAAVCT RGVAKAVDFI PVESMETTMR
SPVYTDNSSP PAVPQTFQVA HLHAPTGSGK STKVPAAYAA QGYKVLVLNP SVAATLGFGA
YMSKAHGVDP NIRTGIRTIT TGAPITYSTY GKFLADGGCS GGAYDIIICD ECHSTDSTSI
//
