ID   I0L8S0_9ACTN            Unreviewed;       332 AA.
AC   I0L8S0;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 46.
DE   SubName: Full=Alcohol dehydrogenase, zinc-binding domain {ECO:0000313|EMBL:CCH20217.1};
GN   ORFNames=MILUP08_45097 {ECO:0000313|EMBL:CCH20217.1};
OS   Micromonospora lupini str. Lupac 08.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=1150864 {ECO:0000313|EMBL:CCH20217.1, ECO:0000313|Proteomes:UP000003448};
RN   [1] {ECO:0000313|Proteomes:UP000003448}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lupac 08 {ECO:0000313|Proteomes:UP000003448};
RX   PubMed=22815450; DOI=10.1128/jb.00628-12;
RA   Alonso-Vega P., Normand P., Bacigalupe R., Pujic P., Lajus A., Vallenet D.,
RA   Carro L., Coll P., Trujillo M.E.;
RT   "Genome Sequence of Micromonospora lupini Lupac 08, Isolated from Root
RT   Nodules of Lupinus angustifolius.";
RL   J. Bacteriol. 194:4135-4135(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCH20217.1}.
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DR   EMBL; CAIE01000037; CCH20217.1; -; Genomic_DNA.
DR   RefSeq; WP_007462967.1; NZ_HF570108.1.
DR   AlphaFoldDB; I0L8S0; -.
DR   STRING; 1150864.MILUP08_45097; -.
DR   eggNOG; COG2130; Bacteria.
DR   OrthoDB; 9805663at2; -.
DR   Proteomes; UP000003448; Unassembled WGS sequence.
DR   GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd05288; PGDH; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR041694; ADH_N_2.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR045010; MDR_fam.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR   PANTHER; PTHR43205:SF7; PROSTAGLANDIN REDUCTASE 1; 1.
DR   Pfam; PF16884; ADH_N_2; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003448}.
FT   DOMAIN          18..330
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   332 AA;  35058 MW;  FCD308D1ADEC5BD6 CRC64;
     MTSNREIHLA SRPEGWPTED TFRLVETDVP TPGPGQIVVR NQFMSVDPYM RGRMNDVKSY
     VPPFALDAPL DGAAIGEVVA SESADVAVGD TVLHGLGWRE YALLDAGAAR QVDPALAPAS
     AYLSVLGMPG LTAYAGLLEV AAMKPGETVF VSAAAGSVGS LVGQIAKLKG AGRVIGSAGS
     AAKVERLRAL GFDAAFDYHD GPVRDSLRAA APDGVDVYFD NVGGDHLEAA ISAMNLHGRA
     AICGMIAQYN DTEPPAAPRN LSLVIGKRLT LRGFLVRDHN HLRDAFVRDV AGWLREGTLS
     YDETVVDGIE NAPAAFLGLL RGENLGKMLV RL
//