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Database: UniProt
Entry: I0LE52_9ACTN
LinkDB: I0LE52_9ACTN
Original site: I0LE52_9ACTN 
ID   I0LE52_9ACTN            Unreviewed;       615 AA.
AC   I0LE52;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   05-JUL-2017, entry version 40.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:CCH22099.1};
GN   ORFNames=MILUP08_30224 {ECO:0000313|EMBL:CCH22099.1};
OS   Micromonospora lupini str. Lupac 08.
OC   Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC   Micromonospora.
OX   NCBI_TaxID=1150864 {ECO:0000313|EMBL:CCH22099.1, ECO:0000313|Proteomes:UP000003448};
RN   [1] {ECO:0000313|Proteomes:UP000003448}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lupac 08 {ECO:0000313|Proteomes:UP000003448};
RX   PubMed=22815450; DOI=10.1128/JB.00628-12;
RA   Alonso-Vega P., Normand P., Bacigalupe R., Pujic P., Lajus A.,
RA   Vallenet D., Carro L., Coll P., Trujillo M.E.;
RT   "Genome Sequence of Micromonospora lupini Lupac 08, Isolated from Root
RT   Nodules of Lupinus angustifolius.";
RL   J. Bacteriol. 194:4135-4135(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:CCH22099.1}.
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DR   EMBL; CAIE01000047; CCH22099.1; -; Genomic_DNA.
DR   RefSeq; WP_007453906.1; NZ_HF570107.1.
DR   EnsemblBacteria; CCH22099; CCH22099; MILUP08_30224.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000003448; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000003448};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003448}.
FT   DOMAIN      309    437       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      521    590       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     317    324       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   615 AA;  68019 MW;  1B2995597D6E3B85 CRC64;
     MAGTTDLAAV WLAATDELAD EIISAQQRAY LRLTRLRAIV EDTALLSVPD AFTRDVIESR
     LRPAITEALT RRLGRPIQVA VTVRVAEDAT GRPAGTVYRS TPEPGLLDVE GPPSGPLGDE
     YTGRPPADEY TGRPAADEAI GEQQRPPATA VPPAPAGPPP ASAVDGHRSG LIPASRDGQE
     ALFSAAFVEP MRSPRPAPER RGYDEQAARL DPPGPDTRPY EPRYREDAAS PRDQHVIRSL
     PRDGATDSGP GRSAVDHRAG GRDDRRLPGT DTGGNRLNPK YMFETFVIGS SNRFAHAASV
     AVAESPAKAY NPLFIYGHSG LGKTHLLHAI GHYATTLGNA RSVRYVSTEE FTNDFINSLR
     DDKTSAFQRR YRDVDILLID DIQFLENRER TQEEFFHTFN TLHNANKQIV ITSDRSPRQL
     ATLEDRMRTR FEWGLLADIQ PPDLETRIAI LQKKAAQERM YAPPDVLEFI ASRVSNSIRE
     LEGALIRVTA FASLTRSTVE LSLAEEVLRD FMPDGAGPEI NADQIMASTA DYFGVSLEDL
     RGQSRSRVLV NARQVAMYLC RELTELSLPR IGQAFGGRDH TTVMHADRKI RQQMAERRSL
     YNQIAELTNR IKQNT
//
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