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Entry: I0R8B6_9FIRM
LinkDB: I0R8B6_9FIRM
Original site: I0R8B6_9FIRM 
ID   I0R8B6_9FIRM            Unreviewed;       378 AA.
AC   I0R8B6;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=Nuclease SbcCD subunit D {ECO:0000256|ARBA:ARBA00013365, ECO:0000256|RuleBase:RU363069};
GN   Name=sbcD {ECO:0000256|RuleBase:RU363069};
GN   ORFNames=HMPREF9970_2660 {ECO:0000313|EMBL:EIC95924.1};
OS   Lachnoanaerobaculum saburreum F0468.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Lachnoanaerobaculum.
OX   NCBI_TaxID=1095750 {ECO:0000313|EMBL:EIC95924.1, ECO:0000313|Proteomes:UP000005039};
RN   [1] {ECO:0000313|EMBL:EIC95924.1, ECO:0000313|Proteomes:UP000005039}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F0468 {ECO:0000313|EMBL:EIC95924.1,
RC   ECO:0000313|Proteomes:UP000005039};
RA   Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA   Nelson K.E.;
RL   Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: SbcCD cleaves DNA hairpin structures. These structures can
CC       inhibit DNA replication and are intermediates in certain DNA
CC       recombination reactions. The complex acts as a 3'->5' double strand
CC       exonuclease that can open hairpins. It also has a 5' single-strand
CC       endonuclease activity. {ECO:0000256|RuleBase:RU363069}.
CC   -!- SUBUNIT: Heterodimer of SbcC and SbcD. {ECO:0000256|ARBA:ARBA00011322,
CC       ECO:0000256|RuleBase:RU363069}.
CC   -!- SIMILARITY: Belongs to the SbcD family. {ECO:0000256|ARBA:ARBA00010555,
CC       ECO:0000256|RuleBase:RU363069}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EIC95924.1}.
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DR   EMBL; AJGH01000060; EIC95924.1; -; Genomic_DNA.
DR   RefSeq; WP_008753809.1; NZ_AJGH01000060.1.
DR   AlphaFoldDB; I0R8B6; -.
DR   PATRIC; fig|1095750.3.peg.1216; -.
DR   eggNOG; COG0420; Bacteria.
DR   OrthoDB; 9773856at2; -.
DR   Proteomes; UP000005039; Unassembled WGS sequence.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd00840; MPP_Mre11_N; 1.
DR   Gene3D; 3.60.21.10; -; 1.
DR   InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR   InterPro; IPR029052; Metallo-depent_PP-like.
DR   InterPro; IPR041796; Mre11_N.
DR   InterPro; IPR004593; SbcD.
DR   InterPro; IPR026843; SbcD_C.
DR   NCBIfam; TIGR00619; sbcd; 1.
DR   PANTHER; PTHR30337; COMPONENT OF ATP-DEPENDENT DSDNA EXONUCLEASE; 1.
DR   PANTHER; PTHR30337:SF0; NUCLEASE SBCCD SUBUNIT D; 1.
DR   Pfam; PF00149; Metallophos; 1.
DR   Pfam; PF12320; SbcD_C; 1.
DR   SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
PE   3: Inferred from homology;
KW   Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW   DNA recombination {ECO:0000256|RuleBase:RU363069};
KW   DNA replication {ECO:0000256|RuleBase:RU363069};
KW   Endonuclease {ECO:0000256|RuleBase:RU363069};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|RuleBase:RU363069};
KW   Hydrolase {ECO:0000256|RuleBase:RU363069};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|RuleBase:RU363069}.
FT   DOMAIN          1..213
FT                   /note="Calcineurin-like phosphoesterase"
FT                   /evidence="ECO:0000259|Pfam:PF00149"
FT   DOMAIN          262..355
FT                   /note="Nuclease SbcCD subunit D C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12320"
SQ   SEQUENCE   378 AA;  43791 MW;  223381474CB4A954 CRC64;
     MKIMHLSDLH LGKRVNEFSM LEDQIYILNE IINIIDEQKP KVIILAGDIY DKPIPPAEAV
     EIFDDFLYKL SKRNLYVFII SGNHDSAERI AFGSRLFDKS GIYLSPVYNG KISPICIDDK
     YGKVNFYMLP FIKPVHVRRF FPDAEIYTYT DALSTVISDM HIDTAQKNIL ITHQFVTGSS
     RTESEDVSVG GSDNVDSDIF KDFDYVALGH IHRSQCCDSE YIRYCGTPLK YSFSESKDIK
     SITMLDIKEK GNIKLDFIPL TPLRDMVEIK GSYNELMLKS FYENTSLTDD YVHITLTDEE
     DIPDVITKLR VVYKNIMKLD YDNQRTKKSS EINPINDMDS KSPLELFDTF YELQNGKHLS
     DTQRVFLKNI IEEIWEYK
//
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