ID I0SW31_STRMT Unreviewed; 437 AA.
AC I0SW31;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=NOL1/NOP2/sun family protein {ECO:0000313|EMBL:EID27584.1};
GN ORFNames=HMPREF1048_0229 {ECO:0000313|EMBL:EID27584.1};
OS Streptococcus mitis SK575.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1095736 {ECO:0000313|EMBL:EID27584.1, ECO:0000313|Proteomes:UP000005505};
RN [1] {ECO:0000313|EMBL:EID27584.1, ECO:0000313|Proteomes:UP000005505}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK575 {ECO:0000313|EMBL:EID27584.1,
RC ECO:0000313|Proteomes:UP000005505};
RA Harkins D.M., Madupu R., Durkin A.S., Torralba M., Methe B., Sutton G.G.,
RA Nelson K.E.;
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. RsmB/NOP family. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01023}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EID27584.1}.
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DR EMBL; AICU01000079; EID27584.1; -; Genomic_DNA.
DR RefSeq; WP_001160247.1; NZ_AICU01000079.1.
DR AlphaFoldDB; I0SW31; -.
DR PATRIC; fig|1095736.3.peg.1437; -.
DR OrthoDB; 9810297at2; -.
DR Proteomes; UP000005505; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:InterPro.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd21147; RsmF_methylt_CTD1; 1.
DR Gene3D; 2.30.130.60; -; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR031341; Methyltr_RsmF_N.
DR InterPro; IPR049560; MeTrfase_RsmB-F_NOP2_cat.
DR InterPro; IPR001678; MeTrfase_RsmB-F_NOP2_dom.
DR InterPro; IPR027391; Nol1_Nop2_Fmu_2.
DR InterPro; IPR023267; RCMT.
DR InterPro; IPR031340; RsmF_methylt_CI.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22807:SF30; 28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR22807; NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING; 1.
DR Pfam; PF01189; Methyltr_RsmB-F; 1.
DR Pfam; PF17125; Methyltr_RsmF_N; 1.
DR Pfam; PF13636; Methyltranf_PUA; 1.
DR Pfam; PF17126; RsmF_methylt_CI; 1.
DR PRINTS; PR02008; RCMTFAMILY.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51686; SAM_MT_RSMB_NOP; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU01023};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01023};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01023}.
FT DOMAIN 1..282
FT /note="SAM-dependent MTase RsmB/NOP-type"
FT /evidence="ECO:0000259|PROSITE:PS51686"
FT ACT_SITE 221
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 99..105
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 123
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
FT BINDING 168
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01023"
SQ SEQUENCE 437 AA; 48588 MW; B753BFD5FCD6124C CRC64;
MQFPEGFVEK YEEILGDEAR DFLASFEEEA VSAFRVNPLK EALVSFSNPI PQTPWGHYGK
VSGKSPEHAT GLVYSQEPAA QMVAQVAQPS PGMKVLDLAA APGGKSTQLA AYLAGEGLLV
SNEISSKRAK ILVENMERFG ATNVVVTNES ADRLSKVFKG YFDLIVLDAP CSGEGMFRKQ
PDAMDYWSLD YPSQCASLQR EILEDAVTML AEGGRLVYST CTWAPEENEE IVNWLLEEYD
FDLLPVEHIN GMVAGIDLPE TARMYPHHFK GEGQFVAHLQ FKGDNPAPKF KASKSNLSRE
QVTLWQEFAQ KHLQVNLRGI LQTFGDQLYL LPELLPDLGK LKIARNGLHL GTFKKKRFEP
SFALGLALKP SQVKQSVEID QEAFVKYVAG ETVQLAESLP NGWYQVLVQG NGLGFAKVTG
NVLKNYFPKG LRFKWKC
//
