ID I0WIB3_9FLAO Unreviewed; 570 AA.
AC I0WIB3;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Efflux transporter, rnd family, mfp subunit {ECO:0000313|EMBL:EID76129.1};
GN ORFNames=W5A_04264 {ECO:0000313|EMBL:EID76129.1};
OS Imtechella halotolerans K1.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Imtechella.
OX NCBI_TaxID=946077 {ECO:0000313|EMBL:EID76129.1, ECO:0000313|Proteomes:UP000005938};
RN [1] {ECO:0000313|EMBL:EID76129.1, ECO:0000313|Proteomes:UP000005938}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K1 {ECO:0000313|EMBL:EID76129.1,
RC ECO:0000313|Proteomes:UP000005938};
RX PubMed=22740661; DOI=10.1128/JB.00506-12;
RA Kumar S., Vikram S., Subramanian S., Raghava G.P., Pinnaka A.K.;
RT "Genome Sequence of the Halotolerant Bacterium Imtechella halotolerans
RT K1T.";
RL J. Bacteriol. 194:3731-3731(2012).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EID76129.1}.
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DR EMBL; AJJU01000003; EID76129.1; -; Genomic_DNA.
DR RefSeq; WP_008237807.1; NZ_AJJU01000003.1.
DR AlphaFoldDB; I0WIB3; -.
DR STRING; 946077.W5A_04264; -.
DR PATRIC; fig|946077.3.peg.869; -.
DR eggNOG; COG0845; Bacteria.
DR OrthoDB; 9806939at2; -.
DR Proteomes; UP000005938; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 6.10.140.730; -; 1.
DR InterPro; IPR021782; DUF3347.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR045800; HMBD.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30097; CATION EFFLUX SYSTEM PROTEIN CUSB; 1.
DR PANTHER; PTHR30097:SF4; SLR6042 PROTEIN; 1.
DR Pfam; PF11827; DUF3347; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR Pfam; PF19335; HMBD; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005938};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..25
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..70
FT /note="Heavy metal binding"
FT /evidence="ECO:0000259|Pfam:PF19335"
FT DOMAIN 106..315
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT DOMAIN 437..523
FT /note="DUF3347"
FT /evidence="ECO:0000259|Pfam:PF11827"
SQ SEQUENCE 570 AA; 63425 MW; 104B7FCFF6AF6903 CRC64;
MRTKRTIGYS ILILIIGIFL GWAIFGSSNH NGHAHEEGVN EAQIWTCSMD PQVRQNEPGK
CPLCGMDLIP LENMDTGGSP NTVVMGKDAV RLANISTITI GFQDAKKELR LNGKVQVDER
KVYAQTTHIP GRIEQLTINF TGETVSRGQQ LAQVYSPDLM TAQEELLQAF RIKESQPELY
EAAKQKLRNW RISESSIQKI ISTQKPIQRF SITADVSGVV TEKKANLGDY VDRGIALYEI
ADLSSVWVLF DVYEADMAWV KKGDKVNYTI ASLPGESFEG VVSFVDPFIN PETRVATARV
EVKNTNGMLK PEMFATGLVI PKQAYIQESQ VIVPKSAVLW TGERSVIYVK KEVDEMMHFE
LREVTLGASL GENYVVKNGL QLGEEVVVNG TFTVDAAAQL AGKPSMMNHE QLPLPVNAED
VSFVEVSKDA KKAMQQVITD YLILKDALVS ADKLVAQKQL GLLMNDFEKV GMQLPGSVWE
PYKIAFTEVL KSMGSKDLEA IRKLFKPLSQ SMIAMVQQFK PHSDALYVQY CPMFEGDKGG
SWLSISKDIK NPYFGDMMLS CGEVKKEIKP
//
