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Database: UniProt
Entry: I0X5Z1_9SPIO
LinkDB: I0X5Z1_9SPIO
Original site: I0X5Z1_9SPIO 
ID   I0X5Z1_9SPIO            Unreviewed;       482 AA.
AC   I0X5Z1;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=MSI_25110 {ECO:0000313|EMBL:EID84057.1};
OS   Treponema sp. JC4.
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
OX   NCBI_TaxID=1124982 {ECO:0000313|EMBL:EID84057.1, ECO:0000313|Proteomes:UP000002967};
RN   [1] {ECO:0000313|EMBL:EID84057.1, ECO:0000313|Proteomes:UP000002967}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JC4 {ECO:0000313|EMBL:EID84057.1,
RC   ECO:0000313|Proteomes:UP000002967};
RX   PubMed=22815447; DOI=10.1128/JB.00754-12;
RA   Rosewarne C.P., Cheung J.L., Smith W.J., Evans P.N., Tomkins N.W.,
RA   Denman S.E., O Cuiv P., Morrison M.;
RT   "Draft genome sequence of Treponema sp. strain JC4, a novel spirochete
RT   isolated from the bovine rumen.";
RL   J. Bacteriol. 194:4130-4130(2012).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747914}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EID84057.1}.
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DR   EMBL; AJGU01000057; EID84057.1; -; Genomic_DNA.
DR   RefSeq; WP_009107610.1; NZ_AJGU01000057.1.
DR   EnsemblBacteria; EID84057; EID84057; MSI_25110.
DR   PATRIC; fig|1124982.3.peg.2438; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002967; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002967};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002967}.
FT   DOMAIN      175    311       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      387    456       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     183    190       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   482 AA;  55285 MW;  2A92853E7975A483 CRC64;
     MYHEAWNYAL EELHNQYISE DRENEFIFNF NINYVSDENN VITVCVPSPF MKNQVTSKGS
     LEIIQNKLRE VTGLNDLTLD CIVNKDFKSA EIPSDDDKEE SKAAESAPAE TQTKAPSATV
     SNSKIESENN SPKQTPVKKH PQLSENFIFE NFIPGDNSMF AYNAAISVAK EPGKARNPIL
     FYGGSGLGKT HLMQAIGNYI YNQNPKLKIC YISAESFTNE FTDSIRTKKT QEFKNKYRGL
     DILLLDDIHF LQGKEQTQEE LFYTFNALFE KKAQMVFTCD RPIREIKNMA DRLVSRLNNG
     LSIDIQIPKF ENRYAILQKK IELQGKQLSP EIIEYIAKNI ETNVRELESA LTTVFSYEEL
     TGRPLDLDSV KTLLHDLIQT NNAENISLEI IQKVVADAYQ ISVADLKGKK KDKKYVVPRQ
     ISIYMAREMT EMSFMELGNE YSGKDHSTIM YAYKKIADLM KTDPSLESRI ENLMREVKEY
     KK
//
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