ID   I1BHK8_RHIO9            Unreviewed;       842 AA.
AC   I1BHK8;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 40.
DE   RecName: Full=Pep3/Vps18/deep orange beta-propeller domain-containing protein {ECO:0000259|Pfam:PF05131};
GN   ORFNames=RO3G_00392 {ECO:0000313|EMBL:EIE75688.1};
OS   Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS   43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX   NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE75688.1, ECO:0000313|Proteomes:UP000009138};
RN   [1] {ECO:0000313|EMBL:EIE75688.1, ECO:0000313|Proteomes:UP000009138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC   {ECO:0000313|Proteomes:UP000009138};
RX   PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA   Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA   Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA   Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA   Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA   Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA   Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT   "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT   whole-genome duplication.";
RL   PLoS Genet. 5:E1000549-E1000549(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC       Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
CC   -!- SIMILARITY: Belongs to the VPS18 family.
CC       {ECO:0000256|ARBA:ARBA00010454}.
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DR   EMBL; CH476732; EIE75688.1; -; Genomic_DNA.
DR   AlphaFoldDB; I1BHK8; -.
DR   STRING; 246409.I1BHK8; -.
DR   VEuPathDB; FungiDB:RO3G_00392; -.
DR   eggNOG; KOG2034; Eukaryota.
DR   InParanoid; I1BHK8; -.
DR   OMA; WIQREKW; -.
DR   OrthoDB; 22879at2759; -.
DR   Proteomes; UP000009138; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR   InterPro; IPR007810; Pep3_Vps18.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR   PANTHER; PTHR23323:SF26; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG; 1.
DR   Pfam; PF00637; Clathrin; 1.
DR   Pfam; PF05131; Pep3_Vps18; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50236; CHCR; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          56..482
FT                   /note="Pep3/Vps18/deep orange beta-propeller"
FT                   /evidence="ECO:0000259|Pfam:PF05131"
SQ   SEQUENCE   842 AA;  96683 MW;  7D85424A638E1A9F CRC64;
     MSLLDDYMES SEAAHGTQTI QFGADAFISS NGFDGLESVR LETGYVSTGF GQIEEPIFGL
     DYVQFQMPAK LIDMAVSNNI LIVALESSRL LKVDLDNPLE VEEIEITRKQ SDGKISKIFF
     DPTGRHLIIT TDHGENYYFY EKWRRTKPLP KLKGVVITSI AWNKQATLTD PSTREILIGT
     KNGLIYETCI EPTDEYFKKE EKYFKQVYSI HESTMPITGL YFEQFPVNNR KYFVMATTTT
     RIYQFIGFVG PSSSNTSSTS GLPSIGNGDI IEDRGERAMF ENLFSKYDIN PGYQELPGEL
     PHSELHFFNR FHELQQQGIA EAFAWLTGPG IYHGSLVFGS QNVGDSVIDV VQLLQYPATP
     SDDESGKLVV EIPISVALTE FHFVLLYKNR VRAICQLNDQ IVYEEMIPIG HGERVVGMTV
     DDIKKTFWIY TTLAMYELTI NNEERDVWKL YLEKKRYNSA LRYCKDPAQK DKVFTAQARD
     YFGQRRYKMS AEIFANSTVP FEEVALMFVE KDEVDALRVY LTNKLTRLRK NDQSQKTMVA
     TWLVELYLSK LNDLEDLASS AHCSPPPNEP ANLEPNTREF FLEQLEDISD EFKSFLETYN
     GHLHRPTTYH LMTTQGRTDE YLFFASLIGD YDKVIGHWIT EKNWTKALNV LSKEADPDVF
     YKFSPVLMEN EPYETNQAIR YLSHVVTTLN NTDPAIHNFL LTLYATQKTA DETVLLAFLK
     NEGSEMHYDL DYALRLCTQN GRTQSCVHIY SQMGLYEEAV NLALKNNDLE LARINADKPE
     DDDLLRKKLW LNIAKHIVQE NKDIKSALEF LKQSNLLKIE DILPFFPDFV LIDDFKVKAN
     II
//