ID   I1BLT9_RHIO9            Unreviewed;       328 AA.
AC   I1BLT9;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 57.
DE   RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN   ORFNames=RO3G_01873 {ECO:0000313|EMBL:EIE77169.1};
OS   Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS   43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX   NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE77169.1, ECO:0000313|Proteomes:UP000009138};
RN   [1] {ECO:0000313|EMBL:EIE77169.1, ECO:0000313|Proteomes:UP000009138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC   {ECO:0000313|Proteomes:UP000009138};
RX   PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA   Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA   Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA   Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA   Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA   Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA   Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT   "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT   whole-genome duplication.";
RL   PLoS Genet. 5:E1000549-E1000549(2009).
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DR   EMBL; CH476732; EIE77169.1; -; Genomic_DNA.
DR   AlphaFoldDB; I1BLT9; -.
DR   STRING; 246409.I1BLT9; -.
DR   VEuPathDB; FungiDB:RO3G_01873; -.
DR   eggNOG; KOG3519; Eukaryota.
DR   InParanoid; I1BLT9; -.
DR   OMA; NHNTIVP; -.
DR   OrthoDB; 23973at2759; -.
DR   Proteomes; UP000009138; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   PANTHER; PTHR47339; CELL DIVISION CONTROL PROTEIN 24; 1.
DR   PANTHER; PTHR47339:SF1; CELL DIVISION CONTROL PROTEIN 24; 1.
DR   Pfam; PF15411; PH_10; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009138}.
FT   DOMAIN          1..175
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
SQ   SEQUENCE   328 AA;  39249 MW;  301597145DFE9DD9 CRC64;
     MRDKVVLELL GTERKYVQDL EVLQDYMHKL QLQFILNTET IHCLFGNLDA LVDFQQRFLI
     QLEDMAQRSP KDQNFGLLFI QNEKRFMVYE LYCSNYFSAQ DMTSQETHRL QRLAYILNPV
     YELPSMLIKP VQRICKYPLL IQELIKATRP DWPYALDVRQ GLESMRRVAE RINETRRRYE
     NALVVNEIKR RVNKLGSSQI DGFGSLLLHD KLSLFQCGIP EQEMQVYLFE QLILICKDNS
     KDSIKLNTIP IKKKRRNSLE FRYGIFYSRI LSVCNQSLDY GKCYLTVNWR DSKIMNITFW
     FRNQEYLELW ESTLKERIVP QYSNKICR
//