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Database: UniProt
Entry: I1BV84_RHIO9
LinkDB: I1BV84_RHIO9
Original site: I1BV84_RHIO9 
ID   I1BV84_RHIO9            Unreviewed;       809 AA.
AC   I1BV84;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   10-MAY-2017, entry version 17.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=RO3G_04819 {ECO:0000313|EMBL:EIE80114.1};
OS   Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS   43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC   Eukaryota; Fungi; Mucoromycota; Mucoromycotina; Mucorales; Mucorineae;
OC   Rhizopodaceae; Rhizopus.
OX   NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE80114.1, ECO:0000313|Proteomes:UP000009138};
RN   [1] {ECO:0000313|EMBL:EIE80114.1, ECO:0000313|Proteomes:UP000009138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC   {ECO:0000313|Proteomes:UP000009138};
RX   PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA   Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA   Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA   Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M.,
RA   Kodira C.D., Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA   Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J.,
RA   Ruiz-Herrera J., Shen Y.-Q., Zeng Q., Galagan J., Birren B.W.,
RA   Cuomo C.A., Wickes B.L.;
RT   "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals
RT   a whole-genome duplication.";
RL   PLoS Genet. 5:E1000549-E1000549(2009).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; CH476734; EIE80114.1; -; Genomic_DNA.
DR   EnsemblFungi; EIE80114; EIE80114; RO3G_04819.
DR   InParanoid; I1BV84; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000009138; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000009138};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    401    425       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    446    465       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    524    544       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    556    578       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    624    643       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    744    770       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       81    115       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   809 AA;  92621 MW;  035C23F13A271791 CRC64;
     MSLIQLYIPA EVAQPCVAEL GELGKVQFRD LNPDVNAFQR SFVSEIRRLD EMERQCRFFQ
     AQLQKSDIYV RPLTPAAYRS RARSAQEVDD LEETLKEYES RITQMNSSYE SLQRRYLQLT
     ELRHVLRESS GFFAHAESRQ ETRRASLDDD SAPLLDNDVH NDFDRLNIGY VTGVIPRARM
     QTFERVLWRS LRGNLYINSA EIDEAIIDPD TDSVVEKNVF AIFAHGSEII AKIKKISESL
     GATLYSIDDS ADKRRDALLE VTNRIEDLNN VLSTTNQTRR SELIKIADNI TPWTTIVRKE
     KAIYHTMNLF NYDVNRKCLI AEGWCPTNDI PLIQQALKDA TDASGTNLPS ILTELETKKT
     PPTYHRTNKF TEGFQGIIDA YGIARYREVN PGLFTVVSSP FSVAVMFGDI GHGALMFLAA
     AYLCINEKKL SQNNGEIFKM FFGGRYMMLM MGLFSIFTGA IYNDIFSLSL NLFKSGFDLP
     SNYTSHQSVE SIPNGNIYPF GLDPAWHGSE NFLLFTNSYK MKQAIIIGVT HMTLAVCLNV
     FNHVYYKRKA FVWLEFLPQI LFMESIFGYL IFCIMYKWSV NWWELDSNGQ HIHNKPPNLL
     NMLIYMFLTP GTVKPEDQLF PGQGPIQAVL LLIAVVCVPW MWFAKPFYLK REASQHHYES
     VAVDDDEEQR AVSHTEDDEE EEEEFDFSEV MIHQTIHTIE FCLNCISNTA SYLRLWALSL
     AHAQLSSVLW DMTLKIWFTM TGPIAVIGLV IGFAMWFVLT IGILLCMEGL SAFLHALRLM
     WVEFDGKFYN GDGIAFQPFT FATVLEPTE
//
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