ID I1BZU2_RHIO9 Unreviewed; 1671 AA.
AC I1BZU2;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN ORFNames=RO3G_06427 {ECO:0000313|EMBL:EIE81722.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE81722.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE81722.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
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DR EMBL; CH476735; EIE81722.1; -; Genomic_DNA.
DR STRING; 246409.I1BZU2; -.
DR VEuPathDB; FungiDB:RO3G_06427; -.
DR eggNOG; KOG0017; Eukaryota.
DR InParanoid; I1BZU2; -.
DR OrthoDB; 1367639at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR001995; Peptidase_A2_cat.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041373; RT_RNaseH.
DR PANTHER; PTHR33064; POL PROTEIN; 1.
DR PANTHER; PTHR33064:SF35; RIBONUCLEASE H; 1.
DR Pfam; PF13650; Asp_protease_2; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17917; RT_RNaseH; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022750};
KW Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT DOMAIN 484..500
FT /note="Peptidase A2"
FT /evidence="ECO:0000259|PROSITE:PS50175"
FT DOMAIN 672..856
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1207..1366
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 1500..1549
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1561..1650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1562..1577
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1581..1604
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1633..1649
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1671 AA; 192342 MW; 5402228ED66326D7 CRC64;
MEDAPLNNAR HAISGEKKNA SRSSKSVSKS KSSIPEKLKR FNRKYDETAD LLDKLVEKRD
LEEDESKRKA LKIQIREYRE DLDYYEEHIT KLEVSANEIS QKINEVGNNT NNTRESEPTV
PIKVIPPFRL LVSAAYNPKY YSSSKVSPDD VKNDNAFKTL QLSIENGQDD RSINWLQHKL
TVADFKNNNW EGAKTALIGK FGESFTYLQY RQKLMRIKQP NGEYLNMYVD RYIDLLTKAK
FADSPLAVMH FLGTLLPPVK DCLERRLAEI RAKKNADFIL EDDTLSKIQT IIENNKMHFI
EECKKIFPGL KNQERSQFKP ADKKAPRQIE TKRKFHGDEQ RYFPENKNRE RNFHKRPAHS
TPKCRYCGEK YTPGHLDKCR EMEKRRDHYL NKDTGFRARK DAPKNYTGNF SQRRRSFEEK
IHNANDSRIT VHNIEKVEKQ TATEPEIMQT HPADEVMNDL LNDDEIISPF QKALKQIREK
KKHKQALVDT GADVSFISKN VVSKLKLRII PVHGSLLLAD KEKTVKRLGV TDKLNVGYKG
QTVAHEFEVL NMHDKVDAIF GRDILPSLGI HLVGVATNWD DNKVKFDDSI EDSEYIPNVS
NAGTPDEHEA LLKALQSHID KNQQIDVHSL CNLPEAVVKL DTSHGKHAHV RQYPIANKMM
PIFDEAVKTW LENGVIVRAP PSPWNSPITF APKKDANGNP TDYRPCIDPR KINALLESDN
YPLPLIDDIF HDLAGSTIFT SLDLKSAFHR LPIRKSDQVK TTFTHRNKQY MFRSAPFGLK
HVSSHFMRIM NLILSDLSNV HVYVDDIVIG TTGDSMEKHY QAVSAVIDRL TQHNMILNPQ
KCHFGKRSVH LLGFCISEKG KSLDPRKLTN IADWPRPKTG REMMQWLGTV NYFRAHIPCA
ATLTAPLDAL RNVAFIDDIN WTRELQVHFQ SIKDILCSNV VLSPYDPTKS LYVATDASNT
GVGAVLFQKF DEKQSDGLTV TTIKYLGFMA RSLSQSERNY SVTRRELLAI VFALKKFHKF
LYGHHFTLYS DHRALTYLFT SDELNPMMVG WMDTLLSYDF DIAHIPGVQN VLPDALSRLF
PPEKELAGSD SNSSTVKHQN LAYKPNLKKE HELKMKKENR KVFYVQSPTK FSDKDYITPP
YEDRQEILDG VHKFGHFGAD HIVKSIHNQN LHWPNLLADA VNYVSKCNTC QKYNIAKKGY
NPHRPVYAYV PGDAYAFDLI GPFQSSSNMY TYVLILVDIC TRFCVLKPLV DKKAKTVAGA
MVDTFSLLGY PRHFVCSDNG SEFKNEILEN LFNAMGIDKR YTTPYHPSAN GAAERYVQSA
KKILAKFLEG ATEDWHHYIP SVQLMINNKI STRLQTTPFS LMFARNINDF IEYRDDAGEL
KKKEYMPHDE LLKRIDYMSQ VVFPAIQDRT DLYTKRQKEK ADSKNRQSTF PEGSYVMVRD
REQYNSLSPV YKGPYRVVRQ VQGGAYILRD VDETLMSRNY SPEELKLISQ DEIIPKDELY
EIEAIINHRG EPGNREYLVR WKNYSKDDDS WLTAEAFTDP ESINIYWRKL GKSINQNGEV
VKKKNNEAEK NKKQKLPSDY APSKLLTTTI MNEQSKSGTM SHNRQSHNTK EKKKAQPKHN
GNALSRYPKR RLQQSQEGFD RKTDHHESSV TQKFITVQTL PIQLPNVDTN W
//