ID I1C1X6_RHIO9 Unreviewed; 1198 AA.
AC I1C1X6;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=RO3G_07161 {ECO:0000313|EMBL:EIE82456.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE82456.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE82456.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
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DR EMBL; CH476736; EIE82456.1; -; Genomic_DNA.
DR AlphaFoldDB; I1C1X6; -.
DR STRING; 246409.I1C1X6; -.
DR VEuPathDB; FungiDB:RO3G_07161; -.
DR eggNOG; KOG4305; Eukaryota.
DR InParanoid; I1C1X6; -.
DR OMA; CFRQKII; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04435; DEP_fRom2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009138}.
FT DOMAIN 517..704
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 903..1198
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 75..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 806..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1198 AA; 135635 MW; 25E3C0BF51A5CBFF CRC64;
MSTEQGPTLR SSPSSTNIYS RYQLPSKNDG SQEQETKQSY TMDHLAYFDS SDTLHPQLTP
SAAIRDRYYQ STRYLQNDSE LDEEDTESIG GDILDYRPAD SEVCAKPEGA PSIYSMTDSV
ISLRTEYNED ARSIHSIRTV DDRLQGRSMT SNLNSFAVKT ARKVSRSGTL FRSRGGGEEK
KKLEPFVPVR DNFARADNSS VKTTGGMSLL SKLSKSTAPV RAKLSALSAF SSKHSRVDTL
AMPGRKRVAE SVYNMPVSVP SKITLSRPFP RMNSDKHIPR STLSTSSSAS STSTNTMIIS
GSLVEEPLSI TRLPSIYPAL LSNVADAFKE SIILSTKTKD SIKYKDAFDG KEAVDVLSGL
IKSSDRNLAL LLGRALDSQK FFHDVNYEHR LRDSSQELYQ FKEHLRPVSV FLPSEQRSLY
DLKSDSVSEF NVDPAETEDL PTGVFTLLTD CYSPTCTRDK LCYSVRCPRR QEQVKKSRGH
SREASQSYMI TQQQEDRLWI NTVPKSLLDT LSKDEKKRQE NIFELVYTEK DFVDDLKYMK
EYWMDPLLDE NSEVTGDRKA LVDKIFWNVQ EVYKVNYQLS QDLLARQSSN QVVDKIGDIL
LSHVGKFYPF VKYGAHQIVG KYTFETEKST NPSFAEFVNK TERLPQSRKL ELNGYLTKPT
TRLGRYNLLL REILKHTPKG HPDQEEIPKA MDIITRFLTD VNIETGIEEN KFNLRLLDER
LVNKHISNLD LDLLSDSRQI IMKGTWKKSS GSESSDVLVY LLDHCLLIIK PKQNEEKYKL
YRKPIPLALL SISFPDQTKR ASTIIPLGRP SNVSSANTTQ NDSVQNNTHQ ASNASLQQNK
NGYPIAFVHL GKQSSGPMTL YAPTLAARKQ WADKIEGQRK ALVEKHKVFH IHSTSERFFS
SFDNKVNCIA VFDKGRSFVL GGDQGVYLKR EGNGDEPVRI LTMDKVSQID VLEQSNLILI
LADKILYAYS LDTLLSIESG IKRGRKISSH VSFFKVGRIL ERSMSDGNGE AVSEEKTLVC
FVRNNAMSST IRALEPYENT EAKKKNKHKH LGRLIRGNNE VLKVYKDLYI PGEASSIQFF
KNVICVGSPR GFQMVNLSSA EVQSVLDPND DNNNALLAHH EYMKPVSMFR HKNGNILLCY
NELAFYIDKK GKRVRKDWCI SWEGSPTAFS FRFPYVVAFN TNFIEVRHID TVSSLIDC
//