ID   I1CBK1_RHIO9            Unreviewed;       430 AA.
AC   I1CBK1;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=RO3G_10541 {ECO:0000313|EMBL:EIE85831.1};
OS   Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS   43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX   NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE85831.1, ECO:0000313|Proteomes:UP000009138};
RN   [1] {ECO:0000313|EMBL:EIE85831.1, ECO:0000313|Proteomes:UP000009138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC   {ECO:0000313|Proteomes:UP000009138};
RX   PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA   Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA   Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA   Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA   Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA   Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA   Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT   "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT   whole-genome duplication.";
RL   PLoS Genet. 5:E1000549-E1000549(2009).
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DR   EMBL; CH476739; EIE85831.1; -; Genomic_DNA.
DR   AlphaFoldDB; I1CBK1; -.
DR   STRING; 246409.I1CBK1; -.
DR   VEuPathDB; FungiDB:RO3G_10541; -.
DR   eggNOG; KOG0017; Eukaryota.
DR   InParanoid; I1CBK1; -.
DR   OMA; SACICEL; -.
DR   OrthoDB; 1363564at2759; -.
DR   Proteomes; UP000009138; Unassembled WGS sequence.
DR   CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 3.30.70.270; -; 3.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR041577; RT_RNaseH_2.
DR   PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR   Pfam; PF17919; RT_RNaseH_2; 1.
DR   Pfam; PF00078; RVT_1; 2.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000009138}.
FT   DOMAIN          105..164
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|Pfam:PF00078"
FT   DOMAIN          167..214
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|Pfam:PF00078"
FT   DOMAIN          278..377
FT                   /note="Reverse transcriptase/retrotransposon-derived
FT                   protein RNase H-like"
FT                   /evidence="ECO:0000259|Pfam:PF17919"
SQ   SEQUENCE   430 AA;  49362 MW;  778D5CBF50185B9C CRC64;
     MVEPLEKHLF SKLEVGEVDK KIIIELRRLL NKYKEIFDWE NDAIGHTKLL KHKIIIEDNA
     HPISHRPYRI NPIEAEYLQK ELDKYCKLGV IAPSNSPWAA PVILVKKKNG DYRMVIDYRK
     LNAITKKDAY PLPRIDDLLD TLGKAKIFSA LDMRAGFHQV PLEQDNDLNV YSLNHHQHLN
     HLEQVFQCIL AANLKLNPEK CFFFKDHLKF LGYMVTKDGI QTDPSKIEKI VNYPIPKSIT
     QVRAFLGLAS YYRRFIKNFA AIARPLHDQT KTSKNIPWTQ KTTDSFEKLK QLLTTAPVLA
     RPDFNKPFLL VTDASKSGLG CILTQLDENG HEHPIVFASR ALKANEANYA ATKLECLAVI
     WAVKQFRPYL LGQKFTIITD HSALNGLLKA SNPTGIIARW ITILTEYEFE IKYRPGRVNE
     SADFLSRLGY
//