ID   I1CIR6_RHIO9            Unreviewed;       614 AA.
AC   I1CIR6;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 41.
DE   RecName: Full=Choline/carnitine acyltransferase domain-containing protein {ECO:0000259|Pfam:PF00755};
GN   ORFNames=RO3G_13057 {ECO:0000313|EMBL:EIE88346.1};
OS   Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS   43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX   NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE88346.1, ECO:0000313|Proteomes:UP000009138};
RN   [1] {ECO:0000313|EMBL:EIE88346.1, ECO:0000313|Proteomes:UP000009138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC   {ECO:0000313|Proteomes:UP000009138};
RX   PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA   Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA   Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA   Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA   Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA   Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA   Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT   "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT   whole-genome duplication.";
RL   PLoS Genet. 5:E1000549-E1000549(2009).
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR   EMBL; CH476742; EIE88346.1; -; Genomic_DNA.
DR   AlphaFoldDB; I1CIR6; -.
DR   STRING; 246409.I1CIR6; -.
DR   VEuPathDB; FungiDB:RO3G_13057; -.
DR   eggNOG; KOG3717; Eukaryota.
DR   InParanoid; I1CIR6; -.
DR   OMA; MAMSSYE; -.
DR   OrthoDB; 1429709at2759; -.
DR   Proteomes; UP000009138; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   PANTHER; PTHR22589:SF115; CARNITINE O-ACETYLTRANSFERASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR   PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU003801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801}.
FT   DOMAIN          28..595
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        321
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   614 AA;  69991 MW;  73D23C23C179431D CRC64;
     MPAHTPKTPI DPKAAGPMLR YQTNLPKLPV PELQETLPKY LKTVRPLLTD EEYKRTEEAV
     KQFIAPGGLG HELQRRLVAR ANNPNVVNWM EDWWLDQAYM GYRDPVVVYV SYFFAYKDDK
     LRKAPAQRAA AITTAALEFK KMVVEKTLEP EYAKGEPMCM DSYKYMFNNC RIAHKPSDLK
     GTFDPFKNTH IIVIRKNKFY FVDTVYNGKQ LSTKELEQQF QRVINDAGDI KGIPVGVLTS
     ENRDKWCDYR DELLAANPAN KQIIDKIESS SFVVCLDDSS PFTRDELVRA CWHGDGRNRY
     FDKSLQFIVF ENGKAGFMGE HSCMDGTATC RLNEYVCDGL ARNLIKHGSE QVRSSIPQPV
     QLQFVLNPNV EKAIETAEKD FEQLINKHEM TVLTYNAFGK NLIKKFKCSP DGFAQMAIQL
     AYYKMFGTSR PTYESGQTRK FQRGRTETCR SVSDESIAFV KAMEDHSIKT EEKIVKLRAA
     LKAQGQYMAA AVNGRGVDRH LFGLKNSLKE GEEKPALFTD YAYSYSSHWY LSTSQLSSEH
     FDGYGWGQVV DDGFGVAYMI KNNALQFNVA SVKDLEVHGK KYINGTHRFK QALEEACDDM
     RDVLLTELPA QAKL
//