ID I1CJT2_RHIO9 Unreviewed; 706 AA.
AC I1CJT2;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=RO3G_13423 {ECO:0000313|EMBL:EIE88712.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE88712.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE88712.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR EMBL; CH476743; EIE88712.1; -; Genomic_DNA.
DR AlphaFoldDB; I1CJT2; -.
DR STRING; 246409.I1CJT2; -.
DR VEuPathDB; FungiDB:RO3G_13423; -.
DR eggNOG; KOG1967; Eukaryota.
DR InParanoid; I1CJT2; -.
DR OMA; GISEHKP; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 43..302
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 524..705
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 706 AA; 79339 MW; CCF79C727B6E8885 CRC64;
MDTARLLEEW LSSNDKIEIE PSFLAYMLLY CTKNEMGLYD IINCLDSFWG TENVICRKKC
IKLLAEIVTP SQSSLNSSAV NAITTSLCKD KFKEPSLLSY FIDIMSTVMH AETIDLTSVI
QLCNILFTEI TVDKLSQQSR YKVLLALGKA IEKYASELQR SKINFIEGFI HCMDGEKDPR
NLMVAFALVR AIIDKFDISR HVEDLFDIVF CYFPIHFIAP TNTDALEITT EDLKRSLRQC
LAATPYFAYY STPLLIEKLL TTTGSAKRDT METISLCAPA YGAHAILPHT LDLFDALTKE
VYTGTDSGMV EIALDTIHHV VATLGTGISI ANIRDPVEKS IDTLLAQCIE KLKEPELKNA
RSAAFILRAV ASASDPACTS VTHAVLPIIY QQYKPTDSSL RQKSILDILI EILIASKKLY
GSVEDVGYDR DFQTPLLMYK QQVLQMFVLS LIDSDSTLRQ TSLKGIHEMV LMKQFLNREE
VKDSINAEGV TAKLHPESIE QYTIPVLLKE LADEEHSLGK YQDVLEAIQS LGVHVNLFKI
ITDPLLKKLD FACSHEVKGN PTYCHELAAC ILAIYRATCK ETVQIGYTTL LPFIMKGCIT
SVLQPKWVLD QQLVETFAII LAITTRLLPI SEQKTLVDNA CKLFILGEYE NQNYEQLMLS
SKIQLPLPNT TEFLDCLFRI ALECDTSNVT LSKTIAIIIN KWMNGK
//
