ID I1CL77_RHIO9 Unreviewed; 1621 AA.
AC I1CL77;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
GN ORFNames=RO3G_13918 {ECO:0000313|EMBL:EIE89207.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE89207.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE89207.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
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DR EMBL; CH476744; EIE89207.1; -; Genomic_DNA.
DR STRING; 246409.I1CL77; -.
DR VEuPathDB; FungiDB:RO3G_13918; -.
DR eggNOG; KOG0017; Eukaryota.
DR InParanoid; I1CL77; -.
DR OrthoDB; 1367639at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00024; CD_CSD; 1.
DR CDD; cd00303; retropepsin_like; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 2.40.70.10; Acid Proteases; 1.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR001969; Aspartic_peptidase_AS.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR33064; POL PROTEIN; 1.
DR PANTHER; PTHR33064:SF35; RIBONUCLEASE H; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF50630; Acid proteases; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00141; ASP_PROTEASE; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Aspartyl protease {ECO:0000256|ARBA:ARBA00022750};
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Protease {ECO:0000256|ARBA:ARBA00022750};
KW Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT DOMAIN 734..917
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1241..1399
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 1535..1593
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 1592..1621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1603..1621
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1621 AA; 182904 MW; 530D763F9A60A326 CRC64;
MVKEDQTPSP FTHGETDTFE TNMEEIPKAI EDTEMTNAEE TSSPMATSHV ASDDKPVDAV
MGLRVTLENL RQQIAHAVIS GAPQEHLKGL QERAVTIKNC IMFLDEAQAF CVSPSTPTGE
AVLGPGNHLN TSYPRSAHVI PPDLPIWQWQ GNVWRKEADV HDSVEDLLDT FALIVESNGL
SIDSSWSRLV PIKMNRDQRS WFNEVLKGRN LVWSEVRSII VKTYAAQDVA QELEYMDQLL
SLKMVPAESI EAFTDRFQRI RRAAKWDDDI RTASIYKRAL PAFLRQEVSR SLLNLGRDQQ
DSVAKVAAKA RVVLSSNLCS EGSLSPRQDS VPVKSLSMSL ASNGTEASKY NPRNSHLLSN
LQGITKKSSS PGNVKNKFHC AIHGLANHPT DKCNKYKNLL SQSSSLVSPS PTTTNPPMSF
VSVAKKCFRC SGNVPWSREH AAICPRDKPY HGPSKAIRSA RLVTSSSNGS KLNLTITPQA
RPQQASSKVS SGDSNLMDVD DEGYPVNYDC KKLTKQNEVF KSTNHSLIVP ITIENVNTMA
LVDSGSSFST IDINFVNKYN IAIDRNVSGS VILATSDNVS KRFGTTKFPL SVIYGDNDNN
LIHTSHSFEV LPLSLDTEVV IGLDLMHKLN ILVTNLAIRH PNLAPVIDKE ITDDTPEPNK
APYGTREQQV HFHNAIKPFV DQNALIPKNS FCTVPESVIR LDTVKGKTAY RAPYRTPFKL
LPIMRECIDT WLKDEVIERA SPNSDWNSPL TLAPKKDLLG NLTGHRPCLD PRLLNSILVS
NDRHPIPKIE EIFDQLQGST IFTTLDLRQA FHRFQIYEPD RVKTTFTFEG QQYQFRGCPF
GLKHIASRYQ RVINIVLRDL PYARAFVDDI IIFSKSYEEH ITHVQNIIQR LTKVNLILNP
DKCHFAQSTV YLLGFCVDAK GSRLDPRKVT NALTWPRPSS GKEIQRFLGL VNYFRKYLPN
ISEVTAPLDK LRFEGKLDKL WTSEQESAFE KIKSLLSSAP LLHHPDLEQP FYVATDASNY
SIGAVLYQVI QNETRYIGFM ARSLSTSEKN YSTTKRELLA VIFALKKFHP FLWGNPFTLY
TDHKALTYLH TQPVANAMMI NWLDTILDYN FKIIHRPGIQ NILPDALSRL FESEKTLEGD
NKTIKTIVTS QIINSNGSIL TSRMMMPADL MTPAPEDRRK LLMDTHLEGH RGAQAIVTAL
HSDGIHWTKL KEDALEIIRS CPDCQKFNIA KHGYNPLTSI YADAPWDHIC INTAGPFPTS
VQGNQYILLV VDVFTRYCVL KALPDKSSLT IALALRSILS LFGRPKIIQS DNGTEYVNEI
VRLYVESSGI DHRLISAYHP RANGIVERWV GKAKNILHKR LQGRTEDWDL YVDSTQEALN
NTHTALHGTR PFSLMFARRP NENKDYNNVL DKTKSPETMK QLETRINEFN DTVLPAIREK
IKTSQTASRD KFNQTHRILT DIPTGSQVTL KNVNRVAKSD PLYVGNYTVK RKTQGGSYVL
VDATGALLPR DVPPSQIKVI SQEVSLSNTD QSESYDVEAV LHHKGSPGNY LYKVRWKGYG
EEDDTWEPAS HFHDYRPIQK YWSRISEQEP AREVQLVPKK DTTKKRKNVH RNVTNSKRNR
R
//