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Database: UniProt
Entry: I1CL77_RHIO9
LinkDB: I1CL77_RHIO9
Original site: I1CL77_RHIO9 
ID   I1CL77_RHIO9            Unreviewed;      1621 AA.
AC   I1CL77;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 53.
DE   RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=RO3G_13918 {ECO:0000313|EMBL:EIE89207.1};
OS   Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS   43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX   NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE89207.1, ECO:0000313|Proteomes:UP000009138};
RN   [1] {ECO:0000313|EMBL:EIE89207.1, ECO:0000313|Proteomes:UP000009138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC   {ECO:0000313|Proteomes:UP000009138};
RX   PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA   Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA   Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA   Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA   Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA   Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA   Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT   "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT   whole-genome duplication.";
RL   PLoS Genet. 5:E1000549-E1000549(2009).
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DR   EMBL; CH476744; EIE89207.1; -; Genomic_DNA.
DR   STRING; 246409.I1CL77; -.
DR   VEuPathDB; FungiDB:RO3G_13918; -.
DR   eggNOG; KOG0017; Eukaryota.
DR   InParanoid; I1CL77; -.
DR   OrthoDB; 1367639at2759; -.
DR   Proteomes; UP000009138; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProt.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   CDD; cd00024; CD_CSD; 1.
DR   CDD; cd00303; retropepsin_like; 1.
DR   CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 1.10.340.70; -; 1.
DR   Gene3D; 2.40.50.40; -; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR016197; Chromo-like_dom_sf.
DR   InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR   InterPro; IPR023780; Chromo_domain.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR041588; Integrase_H2C2.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR041577; RT_RNaseH_2.
DR   PANTHER; PTHR33064; POL PROTEIN; 1.
DR   PANTHER; PTHR33064:SF35; RIBONUCLEASE H; 1.
DR   Pfam; PF00385; Chromo; 1.
DR   Pfam; PF17921; Integrase_H2C2; 1.
DR   Pfam; PF17919; RT_RNaseH_2; 1.
DR   Pfam; PF00665; rve; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SMART; SM00298; CHROMO; 1.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   SUPFAM; SSF54160; Chromo domain-like; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS50013; CHROMO_2; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   4: Predicted;
KW   Aspartyl protease {ECO:0000256|ARBA:ARBA00022750};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Protease {ECO:0000256|ARBA:ARBA00022750};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT   DOMAIN          734..917
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   DOMAIN          1241..1399
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   DOMAIN          1535..1593
FT                   /note="Chromo"
FT                   /evidence="ECO:0000259|PROSITE:PS50013"
FT   REGION          1592..1621
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1603..1621
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1621 AA;  182904 MW;  530D763F9A60A326 CRC64;
     MVKEDQTPSP FTHGETDTFE TNMEEIPKAI EDTEMTNAEE TSSPMATSHV ASDDKPVDAV
     MGLRVTLENL RQQIAHAVIS GAPQEHLKGL QERAVTIKNC IMFLDEAQAF CVSPSTPTGE
     AVLGPGNHLN TSYPRSAHVI PPDLPIWQWQ GNVWRKEADV HDSVEDLLDT FALIVESNGL
     SIDSSWSRLV PIKMNRDQRS WFNEVLKGRN LVWSEVRSII VKTYAAQDVA QELEYMDQLL
     SLKMVPAESI EAFTDRFQRI RRAAKWDDDI RTASIYKRAL PAFLRQEVSR SLLNLGRDQQ
     DSVAKVAAKA RVVLSSNLCS EGSLSPRQDS VPVKSLSMSL ASNGTEASKY NPRNSHLLSN
     LQGITKKSSS PGNVKNKFHC AIHGLANHPT DKCNKYKNLL SQSSSLVSPS PTTTNPPMSF
     VSVAKKCFRC SGNVPWSREH AAICPRDKPY HGPSKAIRSA RLVTSSSNGS KLNLTITPQA
     RPQQASSKVS SGDSNLMDVD DEGYPVNYDC KKLTKQNEVF KSTNHSLIVP ITIENVNTMA
     LVDSGSSFST IDINFVNKYN IAIDRNVSGS VILATSDNVS KRFGTTKFPL SVIYGDNDNN
     LIHTSHSFEV LPLSLDTEVV IGLDLMHKLN ILVTNLAIRH PNLAPVIDKE ITDDTPEPNK
     APYGTREQQV HFHNAIKPFV DQNALIPKNS FCTVPESVIR LDTVKGKTAY RAPYRTPFKL
     LPIMRECIDT WLKDEVIERA SPNSDWNSPL TLAPKKDLLG NLTGHRPCLD PRLLNSILVS
     NDRHPIPKIE EIFDQLQGST IFTTLDLRQA FHRFQIYEPD RVKTTFTFEG QQYQFRGCPF
     GLKHIASRYQ RVINIVLRDL PYARAFVDDI IIFSKSYEEH ITHVQNIIQR LTKVNLILNP
     DKCHFAQSTV YLLGFCVDAK GSRLDPRKVT NALTWPRPSS GKEIQRFLGL VNYFRKYLPN
     ISEVTAPLDK LRFEGKLDKL WTSEQESAFE KIKSLLSSAP LLHHPDLEQP FYVATDASNY
     SIGAVLYQVI QNETRYIGFM ARSLSTSEKN YSTTKRELLA VIFALKKFHP FLWGNPFTLY
     TDHKALTYLH TQPVANAMMI NWLDTILDYN FKIIHRPGIQ NILPDALSRL FESEKTLEGD
     NKTIKTIVTS QIINSNGSIL TSRMMMPADL MTPAPEDRRK LLMDTHLEGH RGAQAIVTAL
     HSDGIHWTKL KEDALEIIRS CPDCQKFNIA KHGYNPLTSI YADAPWDHIC INTAGPFPTS
     VQGNQYILLV VDVFTRYCVL KALPDKSSLT IALALRSILS LFGRPKIIQS DNGTEYVNEI
     VRLYVESSGI DHRLISAYHP RANGIVERWV GKAKNILHKR LQGRTEDWDL YVDSTQEALN
     NTHTALHGTR PFSLMFARRP NENKDYNNVL DKTKSPETMK QLETRINEFN DTVLPAIREK
     IKTSQTASRD KFNQTHRILT DIPTGSQVTL KNVNRVAKSD PLYVGNYTVK RKTQGGSYVL
     VDATGALLPR DVPPSQIKVI SQEVSLSNTD QSESYDVEAV LHHKGSPGNY LYKVRWKGYG
     EEDDTWEPAS HFHDYRPIQK YWSRISEQEP AREVQLVPKK DTTKKRKNVH RNVTNSKRNR
     R
//
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