ID I1CQB5_RHIO9 Unreviewed; 431 AA.
AC I1CQB5;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN ORFNames=RO3G_15356 {ECO:0000313|EMBL:EIE90645.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE90645.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE90645.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
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DR EMBL; CH476747; EIE90645.1; -; Genomic_DNA.
DR AlphaFoldDB; I1CQB5; -.
DR STRING; 246409.I1CQB5; -.
DR VEuPathDB; FungiDB:RO3G_15356; -.
DR eggNOG; KOG2214; Eukaryota.
DR InParanoid; I1CQB5; -.
DR OMA; GYGNIDQ; -.
DR OrthoDB; 154387at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR CDD; cd07229; Pat_TGL3_like; 1.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002641; PNPLA_dom.
DR InterPro; IPR021771; Triacylglycerol_lipase_N.
DR PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR PANTHER; PTHR14226:SF44; TRIACYLGLYCEROL LIPASE 3; 1.
DR Pfam; PF11815; DUF3336; 1.
DR Pfam; PF01734; Patatin; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR PROSITE; PS51635; PNPLA; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000009138}.
FT DOMAIN 74..250
FT /note="PNPLA"
FT /evidence="ECO:0000259|PROSITE:PS51635"
SQ SEQUENCE 431 AA; 48648 MW; 8F825874782CCB72 CRC64;
MTYLLRGGLL RNFGGICDRR LFSHAYLGTK QLIQDYMEEV VTQIEYIEST PDFDAQVKLK
FFSDTRQSFG CSALVLQGGT ALALYHIGVV KALNEQGLLP RIISGTAIGA MIAALICIHT
DEELPNILQP NGINLTAFSN KGATGHFKRR ITRFLKYGYL MDMKVLQECV RANVGDLTFE
EAYSRSKRVL NISVSSSRTQ EVPQLLNYLT APNVLIWSAA CCSTASAGLF GGCHLMAKDK
NGNIVKWISS AVKWNHWSET SPAESEAPLY RLSELFNVNH FIVSQASIYA IPFIAKAQNL
HHETLLHKLA YIIASEFKHR LYQLDQLYLL PQIFRGVIEE KMSGNVNVVP ELNFSDLNIL
FSNPSHQSLA YWILHGERSI WPVMAFIKTR CMIELALDRA VLRLKAMNVE REPVVVRSRY
IENKKRASSM H
//
