ID I1CXW5_9PSEU Unreviewed; 1215 AA.
AC I1CXW5;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=SacglDRAFT_00590 {ECO:0000313|EMBL:EIE97539.1};
OS Saccharomonospora glauca K62.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharomonospora.
OX NCBI_TaxID=928724 {ECO:0000313|EMBL:EIE97539.1, ECO:0000313|Proteomes:UP000005087};
RN [1] {ECO:0000313|EMBL:EIE97539.1, ECO:0000313|Proteomes:UP000005087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K62 {ECO:0000313|EMBL:EIE97539.1,
RC ECO:0000313|Proteomes:UP000005087};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Land M.L., Hauser L., Brambilla E., Klenk H.-P., Woyke T.J.;
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000005087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K62 {ECO:0000313|Proteomes:UP000005087};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Held B., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Pagani I., Brambilla E.-M.,
RA Klenk H.-P., Woyke T.;
RT "Noncontiguous Finished sequence of chromosome of Saccharomonospora glauca
RT K62.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CM001484; EIE97539.1; -; Genomic_DNA.
DR RefSeq; WP_005461569.1; NZ_CM001484.1.
DR AlphaFoldDB; I1CXW5; -.
DR STRING; 928724.SacglDRAFT_00590; -.
DR eggNOG; COG1002; Bacteria.
DR HOGENOM; CLU_269467_0_0_11; -.
DR OrthoDB; 4280289at2; -.
DR Proteomes; UP000005087; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0043412; P:macromolecule modification; IEA:UniProt.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF033451; BREX_2_MTaseX; 1.
DR PANTHER; PTHR33841:SF1; ADENINE-SPECIFIC METHYLTRANSFERASE PGLX; 1.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:EIE97539.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005087};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:EIE97539.1}.
FT REGION 1183..1215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1215 AA; 138639 MW; 2FA6FCCDFA872F17 CRC64;
MVGASKGERQ TVAVRGADLG ELVKDLRRQV TVLEDDLRAR AQEVSEFHTP LRAEYDEARK
RERTAATWES WLDQRVTQVA AAWVLGTVFV RFCEDNGLIQ WPFLAGPGER LADAEERHEA
YFREHPQDND RDWIVAAFNH LAEAHPTAAG LFDARFNPLW EITPSFEAAT ALLQFWRRRG
DDGEIRYDFT DPEWDTRFLG DLYQDLSEHA RKTYALLQTP EFVEEFILDL TLEPAVEEFG
LKGLRTIDPA CGSGHFLLGL FRRVLAKWRE AEPGTDQWEL IQRTLGSVHG CDKNPFAASI
ARFRMLVAVL REANAIRLDQ APRFPINIAV GDSLMHGRGA PGIQGELFAL DEPHTYTTED
VNEYVRSCDL LGKGSYHVVV GNPPYITVKD KQENQNYRDR YDACSGKYAL SVPFAQRLFQ
LAIRRSGSDR DAGYVGQITA NSFMKREFGK KLIEDFFRTV QLTHVIDTSG AYIPGHGTPT
VILVGRNHEY RQDDPVRAVL GIRGEPSQPE DPAKGLVWSA IVEQITRPGS ESEWITAEDV
DRTAFAGHPW SLSGGGAGDL QDRIQSGGSM LLGKCFESSG FAAITGVDDA YVLASPLPRW
RENQDVQRRV YVEGDQVRDW ACGATAKVVY PIDLNVDERS YIETVYLWSM RSVLRRTIYF
GETKEERGYH WSDYAFFMRE RLKSRLLIAF AFVATHNHFT LDRGGKVHNK SAPVIKLPEG
AGEDEHLELL GVLNSSTACF WLKQVCHNKG GPGGGYSKGE KWRDFYEFTG TKLQEFPLPA
VLPLELGRAL DSLAQDLAAQ EPSAIAEAAT PTRERLDAAR AEHARIRGRM IALQEELDWT
VYHSYGLLDD TERAQLTAPD LDTVPEIRLG ERAFEIVLTR RMRAGLEETR WFTDFGGQPQ
TEVPEHWPEW YRQLVQARID VIEKRRDIAL IEQPNCKRPW ESETWERKEA DALRTWLLDR
CERRDLWFGL RDGFEQPRTL TVHQLADAFR DDADMHAVAA LYANDHLGKP DLPLAKVLET
ILTDQHVPYL AALRYKDSGL RKRAQWEQVW EKQREEDRTG QRLDIPVPPK YTSADFRKTS
YWTHRGKLDV PKERFISYPD ASPDADPSLL LGWAGWDHKD QAQALVNLIN DRTADAGWET
ERLTPLLAGL AEVMPWVRQW HGEYDEEWEG VPADEYQAFL DEQRTKHQLT EDDLKNWRPA
PTRRGRRGTA KETQQ
//
