ID I1D122_9PSEU Unreviewed; 583 AA.
AC I1D122;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase {ECO:0000313|EMBL:EIE98646.1};
GN ORFNames=SacglDRAFT_01735 {ECO:0000313|EMBL:EIE98646.1};
OS Saccharomonospora glauca K62.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharomonospora.
OX NCBI_TaxID=928724 {ECO:0000313|EMBL:EIE98646.1, ECO:0000313|Proteomes:UP000005087};
RN [1] {ECO:0000313|EMBL:EIE98646.1, ECO:0000313|Proteomes:UP000005087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K62 {ECO:0000313|EMBL:EIE98646.1,
RC ECO:0000313|Proteomes:UP000005087};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Land M.L., Hauser L., Brambilla E., Klenk H.-P., Woyke T.J.;
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000005087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K62 {ECO:0000313|Proteomes:UP000005087};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Held B., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Pagani I., Brambilla E.-M.,
RA Klenk H.-P., Woyke T.;
RT "Noncontiguous Finished sequence of chromosome of Saccharomonospora glauca
RT K62.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; CM001484; EIE98646.1; -; Genomic_DNA.
DR RefSeq; WP_005463540.1; NZ_CM001484.1.
DR AlphaFoldDB; I1D122; -.
DR STRING; 928724.SacglDRAFT_01735; -.
DR eggNOG; COG0028; Bacteria.
DR HOGENOM; CLU_013748_4_0_11; -.
DR OrthoDB; 2443624at2; -.
DR Proteomes; UP000005087; Chromosome.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02002; TPP_BFDC; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR000399; TPP-bd_CS.
DR InterPro; IPR045229; TPP_enz.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR PANTHER; PTHR18968:SF164; PYRUVATE DECARBOXYLASE; 1.
DR PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR PROSITE; PS00187; TPP_ENZYMES; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000313|EMBL:EIE98646.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000005087};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 16..146
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 221..329
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 430..577
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 583 AA; 62576 MW; F4B095AE94442DEF CRC64;
MGSDETSPQT AATGYTTSKA FLEALAEGGV RYVFANLGSD HPGILEAYAQ ARVEGREHAF
PELVICPHES VAMAAALGYA QVTGVPQAVM VHVECGTQNI GGMLHNAAKG RIGVLMYAGA
SPFTQEGELF GSRNEFIQWI QDVHDQRGIV RGYTKYDNEI RTGANVKQLV HRALQIARSA
PAGPVYLVGP REVMESEAPT RQADAAHFPP VAPAALAPDV VDRVASALAE ARRPVVVTSY
LGRDREAVPA LVELCEAAGA GVLESVPSYV NFPADHPLHW GFQWNDQHHN PLLEEADVVL
VLGSDVPWIP TKNRPNAEAR VFVVDEDPLK DQMPLWHVPA ELFARADLGT AVRQLHHRVA
ELADPAVVAR RRELAAAEHE RLWAERARRE TPVGETITPE YLVACVRDAI DDDTLVLTEA
ITHYPTVSWH LHRTVPGSLL GSGAGSLGWA IGAAVGAKLA EPERTVVSLV GDGSYLFGVP
SSVFWMARRY GAPSLTVVFD NKGWNAPKAS TLGVHPKGTA AQRDDFGVHF TDRPDLPGIA
EAAGGAWGRT VEAASELKDA LAEALAAVRA GRPAVLAVRV PEM
//
