ID I1D1Z0_9PSEU Unreviewed; 512 AA.
AC I1D1Z0;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:EIE98964.1};
GN ORFNames=SacglDRAFT_02058 {ECO:0000313|EMBL:EIE98964.1};
OS Saccharomonospora glauca K62.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharomonospora.
OX NCBI_TaxID=928724 {ECO:0000313|EMBL:EIE98964.1, ECO:0000313|Proteomes:UP000005087};
RN [1] {ECO:0000313|EMBL:EIE98964.1, ECO:0000313|Proteomes:UP000005087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K62 {ECO:0000313|EMBL:EIE98964.1,
RC ECO:0000313|Proteomes:UP000005087};
RG US DOE Joint Genome Institute (JGI-PGF);
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Land M.L., Hauser L., Brambilla E., Klenk H.-P., Woyke T.J.;
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000005087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K62 {ECO:0000313|Proteomes:UP000005087};
RG US DOE Joint Genome Institute;
RA Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S.,
RA Peters L., Mikhailova N., Held B., Detter J.C., Han C., Tapia R., Land M.,
RA Hauser L., Kyrpides N., Ivanova N., Pagani I., Brambilla E.-M.,
RA Klenk H.-P., Woyke T.;
RT "Noncontiguous Finished sequence of chromosome of Saccharomonospora glauca
RT K62.";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the flavin-dependent halogenase family.
CC Bacterial tryptophan halogenase subfamily.
CC {ECO:0000256|ARBA:ARBA00038396}.
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DR EMBL; CM001484; EIE98964.1; -; Genomic_DNA.
DR RefSeq; WP_005464174.1; NZ_CM001484.1.
DR AlphaFoldDB; I1D1Z0; -.
DR STRING; 928724.SacglDRAFT_02058; -.
DR eggNOG; COG0644; Bacteria.
DR HOGENOM; CLU_022247_0_0_11; -.
DR OrthoDB; 8868802at2; -.
DR Proteomes; UP000005087; Chromosome.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000005087}.
FT ACT_SITE 75
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 10..13
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 75
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 195
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 345
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 354
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 358
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 512 AA; 57775 MW; 3C1CE5413AB844BB CRC64;
MIHSVVIVGG GTAGWMTASY LKAAFADRID VTLVESAAVS RIGVGEATFS TIRHFFDYLG
LDEADWLPKC AGGYKLGIRF ENWHGNGEYF YHPFERLRVV DGFSLADWWL AIGDHSRPMD
RQVFLTSALC EAKRSPRMMD GSLFVSGLDG SLGKSTLAEQ RAQFPYAYHF DADQVAAYLR
SYATERGVRH VVDNVQEVLQ DQCGWISGVR TAEHGVLTGD LFVDCTGFRG ILINKTLGTK
FESFEDVLPN NRAVALRVPR ETETDMAPYT TARAMSAGWM WTIPLFRRNG NGYVYSDQFI
TPEEAERELR EAVAPDRDDL EANHIRMRIG RNERSWVKNC VAVGLSSAFV EPLESTGIFF
IQHAIEQLVK HFPDKTFDPA LIEAYNRRIN RAIDGVKEFL VLHYKASSRA DTPYWKESKV
RAMPEPLAER LKLAETQLFD EETIYPHYHG FESYSWNSMI IGLGYRPKKP LPALAHLDPT
DALAEFDKIK TEAAEMVAAL PSCYDYLASL NE
//
