ID I1ID73_BRADI Unreviewed; 479 AA.
AC I1ID73;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN Name=100834803 {ECO:0000313|EnsemblPlants:KQK01014};
GN ORFNames=BRADI_3g53310v3 {ECO:0000313|EMBL:KQK01014.1};
OS Brachypodium distachyon (Purple false brome) (Trachynia distachya).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Stipodae; Brachypodieae; Brachypodium.
OX NCBI_TaxID=15368 {ECO:0000313|EMBL:KQK01014.1};
RN [1] {ECO:0000313|EMBL:KQK01014.1, ECO:0000313|EnsemblPlants:KQK01014}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK01014.1,
RC ECO:0000313|EnsemblPlants:KQK01014};
RX PubMed=20148030; DOI=10.1038/nature08747;
RG International Brachypodium Initiative;
RT "Genome sequencing and analysis of the model grass Brachypodium
RT distachyon.";
RL Nature 463:763-768(2010).
RN [2] {ECO:0000313|EMBL:KQK01014.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Bd21 {ECO:0000313|EMBL:KQK01014.1};
RG The International Brachypodium Initiative;
RA Lucas S., Harmon-Smith M., Lail K., Tice H., Grimwood J., Bruce D.,
RA Barry K., Shu S., Lindquist E., Wang M., Pitluck S., Vogel J.P.,
RA Garvin D.F., Mockler T.C., Schmutz J., Rokhsar D., Bevan M.W.;
RT "WGS assembly of Brachypodium distachyon.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:KQK01014}
RP IDENTIFICATION.
RC STRAIN=cv. Bd21 {ECO:0000313|EnsemblPlants:KQK01014};
RG EnsemblPlants;
RL Submitted (AUG-2018) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; CM000882; KQK01014.1; -; Genomic_DNA.
DR RefSeq; XP_003570232.1; XM_003570184.3.
DR AlphaFoldDB; I1ID73; -.
DR EnsemblPlants; KQK01014; KQK01014; BRADI_3g53310v3.
DR GeneID; 100834803; -.
DR Gramene; KQK01014; KQK01014; BRADI_3g53310v3.
DR KEGG; bdi:100834803; -.
DR eggNOG; KOG1430; Eukaryota.
DR HOGENOM; CLU_007383_6_8_1; -.
DR OMA; YFPLDEH; -.
DR OrthoDB; 5487986at2759; -.
DR Proteomes; UP000008810; Chromosome 3.
DR ExpressionAtlas; I1ID73; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028110; TMEM254.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR Pfam; PF14934; TMEM254; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008810};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 383..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..445
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 457..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 15..292
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 479 AA; 53366 MW; 6C9764A81A169E21 CRC64;
MHLSENEGIE GVRFAVTGGQ GFVGAALCLE LLRRGAQEVR SLDLRASSSW SQQLLDAGVR
FFQGDVRKKE DVERVFRNVD CVFHLASYGM SGKEMVQTGR TDDININGTC NVLDACHEHG
VRRLVYVSTY NVVFGGEPIV NGNETLPYFP IEDHVDAYGR SKSIAEQLVL KSNARQAKSS
KSTRLYTCAI RPAAIYGPGE ERHLPRILSL AKLGLAFFKI GGPNVKTDWL YVDNLVLALI
LASMGLLDDI PGRKGTPVAA GQAYFICDGA PVNTFEFIIS PLFRSLGYAV PRVKLDTPIA
LAISRFFLFI CTLFYPWLDS KWIAQPLILP AEVYKVGVTH YFSFLKAKEE LGYVPMTSPR
EGLAATISYW QERKRRELDG PTIFTWLAVT IGMLAIFSAA CLPPVGPLKW LLAIHLFVFR
KMLVIRLVFL AAVVAHAAEG VYAWFLAKKV DPRNAAGWFW QTFALGVFSL RYLLKRARV
//
