ID I1QNJ5_ORYGL Unreviewed; 731 AA.
AC I1QNJ5;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=4-coumarate--CoA ligase {ECO:0000256|ARBA:ARBA00012959};
DE EC=6.2.1.12 {ECO:0000256|ARBA:ARBA00012959};
OS Oryza glaberrima (African rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=4538 {ECO:0000313|EnsemblPlants:ORGLA09G0062400.1, ECO:0000313|Proteomes:UP000007306};
RN [1] {ECO:0000313|Proteomes:UP000007306}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IRGC 96717 {ECO:0000313|Proteomes:UP000007306};
RA Wing R.A., Yu Y., Rounsley S., Reddy-Marri P., Goicoechea J.L.,
RA Sisneros N., Lee S., Song X., Angelova A., Kudrna D.P., de Baynast K.,
RA Zuccolo A.;
RT "The complete genome of Oryza glaberrima.";
RL Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:ORGLA09G0062400.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(E)-4-coumarate + ATP + CoA = (E)-4-coumaroyl-CoA + AMP +
CC diphosphate; Xref=Rhea:RHEA:19641, ChEBI:CHEBI:12876,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:85008, ChEBI:CHEBI:456215; EC=6.2.1.12;
CC Evidence={ECO:0000256|ARBA:ARBA00034252};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19642;
CC Evidence={ECO:0000256|ARBA:ARBA00034252};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(E)-4-coumarate + ATP + H(+) = (E)-4-coumaroyl-AMP +
CC diphosphate; Xref=Rhea:RHEA:72419, ChEBI:CHEBI:12876,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:192348; Evidence={ECO:0000256|ARBA:ARBA00034219};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72420;
CC Evidence={ECO:0000256|ARBA:ARBA00034219};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(E)-4-coumaroyl-AMP + CoA = (E)-4-coumaroyl-CoA + AMP + H(+);
CC Xref=Rhea:RHEA:72423, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:85008, ChEBI:CHEBI:192348, ChEBI:CHEBI:456215;
CC Evidence={ECO:0000256|ARBA:ARBA00034223};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:72424;
CC Evidence={ECO:0000256|ARBA:ARBA00034223};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR AlphaFoldDB; I1QNJ5; -.
DR STRING; 4538.I1QNJ5; -.
DR EnsemblPlants; ORGLA09G0062400.1; ORGLA09G0062400.1; ORGLA09G0062400.
DR Gramene; ORGLA09G0062400.1; ORGLA09G0062400.1; ORGLA09G0062400.
DR eggNOG; KOG1175; Eukaryota.
DR HOGENOM; CLU_000022_3_8_1; -.
DR OMA; TGWIMYM; -.
DR Proteomes; UP000007306; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016207; F:4-coumarate-CoA ligase activity; IEA:UniProt.
DR GO; GO:0106290; F:trans-cinnamate-CoA ligase activity; IEA:UniProt.
DR GO; GO:0009698; P:phenylpropanoid metabolic process; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR44378; ACYL-ACTIVATING ENZYME 17, PEROXISOMAL-RELATED; 1.
DR PANTHER; PTHR44378:SF2; ACYL-ACTIVATING ENZYME 17, PEROXISOMAL-RELATED; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 252..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 130..185
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 192..560
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
SQ SEQUENCE 731 AA; 78745 MW; B46FA24CD5C9F425 CRC64;
MGHAAAAAAA AHVPLGAITV DDLLAAGVAG GAAAELHEAV RRAVGARGGD GDAAAVWGEL
CRAALRPGVP FAVHRMLYYG CFAGFPSATP PAWTPDPEEA VLTNVGRVLE ARGREFLGDK
YKDPIASFTD FHKFSIENPE AYWKMVFEEM GITFSVEPSC ILRENDAYPG GEWLPGAVLN
AAANCLTAKP GRSSDDVAIV WRDEGKDSEP LNFVTLEELR KKVCLVANAL DALNLAKGSA
IAIDMPMNVN AVVIYLAIVL AGYVVVSIAD SFAAPAISMR LKISEAKAIF TQDYILRDDK
ELPLYSRVVE AKAPMTIVIP VRGSTPIKGM RADDLSWEDF LAKVNHAKAD NYTAVEQPAY
AFTNILFSSG TTGEPKAIPW THLTPLKSAA DGWCHMDIRR GDVVAWPTNL GWMMGPWLVY
ASLLNGASMA LYNGSLNSSG FAKFVQDAKV TMLGLVPSIA RSWKSTDCTA GFDWSTIRCF
SSSGEASSVD DYLWLMGRVC YKPVIEYCGG TEIGGGFVAG SLLQPQALSA FSTPAMGCNL
FILDNNGNPL PQDSVGTGEL ALDPTFLGAS TTLLNADHHE VYFSGMPEWN GKVLRRHGDE
FERTPDGYYR AHGRADDTMN LGGIKVSSIE IERICNRVND AILETAAIGV PPLGGGPEQL
TIAVVFKDQS SQTEDLNQLK LAFNTALKKL NPLFKVSSVV AVPSLPRTAS NKVMRRVLRK
EFTQQPKHSK I
//
