ID I1VAN0_9CRUS Unreviewed; 278 AA.
AC I1VAN0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=MyD88 {ECO:0000313|EMBL:AFI39844.1};
DE Flags: Fragment;
OS Daphnia parvula.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Branchiopoda;
OC Diplostraca; Cladocera; Anomopoda; Daphniidae; Daphnia.
OX NCBI_TaxID=132684 {ECO:0000313|EMBL:AFI39844.1};
RN [1] {ECO:0000313|EMBL:AFI39844.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A60 {ECO:0000313|EMBL:AFI39844.1};
RX PubMed=22577801; DOI=10.1186/1471-2148-12-63;
RA McTaggart S.J., Obbard D.J., Conlon C., Little T.J.;
RT "Immune genes undergo more adaptive evolution than non-immune system genes
RT in Daphnia pulex.";
RL BMC Evol. Biol. 12:63-63(2012).
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DR EMBL; JQ856498; AFI39844.1; -; mRNA.
DR GO; GO:0070976; F:TIR domain binding; IEA:InterPro.
DR GO; GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; IEA:InterPro.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:InterPro.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR017281; Myelin_different_resp_MyD88.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR15079; MYD88; 1.
DR PANTHER; PTHR15079:SF3; MYELOID DIFFERENTIATION PRIMARY RESPONSE PROTEIN MYD88; 1.
DR Pfam; PF13676; TIR_2; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 2: Evidence at transcript level;
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198}.
FT DOMAIN 96..228
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 231..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFI39844.1"
FT NON_TER 278
FT /evidence="ECO:0000313|EMBL:AFI39844.1"
SQ SEQUENCE 278 AA; 32045 MW; EB640B8EEABDDE64 CRC64;
LAELMGCDML IIQNLEKTSN PFAGLISQAK DLTAIQLIEY LEKMDRYDVV DDTIALMEND
LYLASRQSXL QETKQBIPQI VTIGDQEQFS EDGTLVQYDA FVLYAREDQE FVNTVVKKIE
GEYGMKLCLK ERDFIAGLPF EHQAVTELIS NRCRFVLPIF SPNFLNSEDN KFVVNFSEAL
GIERGCRKIV PCVYQQCDLP KSVRYYTRLD FTRQNPYWDF WDKMKKSLAD PYAPPSERTD
KTNVSNTENK TEQKYLAQLS PKGDLPEKSK SYPENVPP
//
