ID I1W700_ANGJA Unreviewed; 243 AA.
AC I1W700;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Hox-B4a {ECO:0000313|EMBL:AFI61982.1};
GN Name=HOXB4A {ECO:0000313|EMBL:AFI61982.1};
OS Anguilla japonica (Japanese eel).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Anguilliformes; Anguillidae;
OC Anguilla.
OX NCBI_TaxID=7937 {ECO:0000313|EMBL:AFI61982.1};
RN [1] {ECO:0000313|EMBL:AFI61982.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23026207; DOI=10.1016/j.gene.2012.09.064;
RA Henkel C.V., Dirks R.P., de Wijze D.L., Minegishi Y., Aoyama J.,
RA Jansen H.J., Turner B., Knudsen B., Bundgaard M., Hvam K.L., Boetzer M.,
RA Pirovano W., Weltzien F.A., Dufour S., Tsukamoto K., Spaink H.P.,
RA van den Thillart G.E.;
RT "First draft genome sequence of the Japanese eel, Anguilla japonica.";
RL Gene 511:195-201(2012).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis.
CC {ECO:0000256|ARBA:ARBA00003263}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. Deformed subfamily.
CC {ECO:0000256|ARBA:ARBA00038235}.
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DR EMBL; JQ976898; AFI61982.1; -; Genomic_DNA.
DR AlphaFoldDB; I1W700; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45771:SF3; HOMEOBOX PROTEIN HOX-B4; 1.
DR PANTHER; PTHR45771; HOMEOTIC PROTEIN DEFORMED; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 145..205
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 147..206
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 83..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 243 AA; 27630 MW; EA1963793E205695 CRC64;
MAMSSFLINS NYVDPKFPPC EEYSQNDYLP SHSPDYYSAQ RRDTAFQDGP MYHQRSGCAD
PPFTPCQGPG HPTAVMSPRA HVLPQTGLSN PLPETNSHHC HSATPSPPPS VNQSNSSSSS
CKDPVVYPWM KKVHVNTVNP NYTGGEPKRS RTAYTRQQVL ELEKEFHYNR YLTRRRRVEI
AHTLCLSERQ IKIWFQNRRM KWKKDHKLPN TKIRSTNSSS SNTRDSQTHG NSQSRTSGPP
SSL
//
