ID   I1X9A4_9AQUI            Unreviewed;       234 AA.
AC   I1X9A4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Serine hydroxymethyltransferase {ECO:0000313|EMBL:AFI80200.1};
DE   Flags: Fragment;
GN   Name=glyA {ECO:0000313|EMBL:AFI80200.1};
OS   Persephonella sp. IF05-L6.
OC   Bacteria; Aquificota; Aquificae; Aquificales; Hydrogenothermaceae;
OC   Persephonella.
OX   NCBI_TaxID=1158336 {ECO:0000313|EMBL:AFI80200.1};
RN   [1] {ECO:0000313|EMBL:AFI80200.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=IF05-L6 {ECO:0000313|EMBL:AFI80200.1};
RA   Wagner I.D., Liu Y., Reysenbach A.-L.;
RT   "Spatial Diversity Patterns of Aquificales from Deep-Sea Hydrothermal
RT   Vents.";
RL   Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC   -!- SIMILARITY: Belongs to the SHMT family.
CC       {ECO:0000256|ARBA:ARBA00006376}.
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DR   EMBL; JN856134; AFI80200.1; -; Genomic_DNA.
DR   AlphaFoldDB; I1X9A4; -.
DR   GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:InterPro.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:InterPro.
DR   CDD; cd00378; SHMT; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   InterPro; IPR001085; Ser_HO-MeTrfase.
DR   InterPro; IPR019798; Ser_HO-MeTrfase_PLP_BS.
DR   InterPro; IPR039429; SHMT-like_dom.
DR   PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR   PANTHER; PTHR11680:SF28; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR   Pfam; PF00464; SHMT; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00096; SHMT; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Methyltransferase {ECO:0000313|EMBL:AFI80200.1};
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AFI80200.1}.
FT   DOMAIN          1..234
FT                   /note="Serine hydroxymethyltransferase-like"
FT                   /evidence="ECO:0000259|Pfam:PF00464"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AFI80200.1"
FT   NON_TER         234
FT                   /evidence="ECO:0000313|EMBL:AFI80200.1"
SQ   SEQUENCE   234 AA;  25505 MW;  A5D0B9AEDDF9C221 CRC64;
     LTHGAKVNLS GIVFNSVQYG VNPETELIDY DEVYRLAKEH KPKMIVAGAS AYSRIIDWAK
     FKEIADEVGA LLMVDMAHYA GLIAGDAYPS PVPYADFVTS TTHKTLRGPR GGFILSKAEY
     AKDIDKWVFP RLQGGPLMHV IAAKAVAFKE AMTPEFREYA HQTVKNAKAL AEELKAEGLR
     IVSGGTDSHI VLVDLRPLNV KGNQAEEALG KANITVNKNA IPFDPEKPMV TSGI
//