ID I1YAM3_HHV1 Unreviewed; 376 AA.
AC I1YAM3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Thymidine kinase {ECO:0000313|EMBL:AFI99042.1};
GN Name=UL23 {ECO:0000313|EMBL:AFI99042.1};
OS Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC Simplexvirus humanalpha1.
OX NCBI_TaxID=10298 {ECO:0000313|EMBL:AFI99042.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AFI99042.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=3576/2009 {ECO:0000313|EMBL:AFI99042.1};
RX PubMed=22155911; DOI=10.3851/IMP1870;
RA Sauerbrei A., Bohn K., Heim A., Hofmann J., Weissbrich B., Schnitzler P.,
RA Hoffmann D., Zell R., Jahn G., Wutzler P., Hamprecht K.;
RT "Novel resistance-associated mutations of thymidine kinase and DNA
RT polymerase genes of herpes simplex virus type 1 and type 2.";
RL Antivir. Ther. 16:1297-1308(2011).
RN [2] {ECO:0000313|EMBL:AFI99042.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=3576/2009 {ECO:0000313|EMBL:AFI99042.1};
RA Zell R., Bohn K., Sauerbrei A.;
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; JQ352265; AFI99042.1; -; Genomic_DNA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006230; P:TMP biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_04029; HSV_KITH; 1.
DR InterPro; IPR001889; Herpes_TK.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00693; Herpes_TK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AFI99042.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AFI99042.1}.
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 40971 MW; D5BA1E9D862B7B47 CRC64;
MASYPCHQHA SAFDQAARSR GHSNRRTALR PRRQQEATEV RLEQKMPTLL RVYIDGPHGM
GKTTTTQLLV ALGSRDDIVY VPEPMTYWQV LGASETIANI YTTQHRLDQG EISAGDAVVV
MTSAQITMGM PYAVTDAVLA PHIGGEAGSS HAPPPALTLI FDRHPIAALL CYPAARYLMG
SMTPQAVLAF VALIPPTLPC TNIVLGALPE DRHIDRLAKR QRPGERLDLA MLAAIRRVYG
LLANTVRYLQ GGGSWREDWG QLSGTAVPPQ GAEPQSNAGP RPHIGDTLFT LFRAPELLAP
NGDLYNVFAW ALDVLAKRLR PMHVFILDYD QSPAGCRDAL LQLTSGMVQT HVTTPGSIPT
ICDLARTFAR EMGEAN
//
