ID I2AHU1_9MYCO Unreviewed; 613 AA.
AC I2AHU1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=protein-glutamate O-methyltransferase {ECO:0000256|ARBA:ARBA00012534};
DE EC=2.1.1.80 {ECO:0000256|ARBA:ARBA00012534};
GN ORFNames=W7S_19560 {ECO:0000313|EMBL:AFJ36865.1};
OS Mycobacterium sp. MOTT36Y.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=1168287 {ECO:0000313|EMBL:AFJ36865.1, ECO:0000313|Proteomes:UP000002868};
RN [1] {ECO:0000313|EMBL:AFJ36865.1, ECO:0000313|Proteomes:UP000002868}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MOTT36Y {ECO:0000313|EMBL:AFJ36865.1,
RC ECO:0000313|Proteomes:UP000002868};
RX PubMed=22815454; DOI=10.1128/JB.00752-12;
RA Kim B.J., Choi B.S., Choi I.Y., Lee J.H., Chun J., Hong S.H., Kook Y.H.,
RA Kim B.J.;
RT "Complete genome sequence of Mycobacterium intracellulare clinical strain
RT MOTT-36Y, belonging to the INT5 genotype.";
RL J. Bacteriol. 194:4141-4142(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-
CC glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:24452, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:10311,
CC ChEBI:CHEBI:29973, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:82795; EC=2.1.1.80;
CC Evidence={ECO:0000256|ARBA:ARBA00001541};
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DR EMBL; CP003491; AFJ36865.1; -; Genomic_DNA.
DR RefSeq; WP_014712182.1; NC_017904.1.
DR AlphaFoldDB; I2AHU1; -.
DR KEGG; mmm:W7S_19560; -.
DR PATRIC; fig|1168287.3.peg.3970; -.
DR HOGENOM; CLU_000892_4_0_11; -.
DR Proteomes; UP000002868; Chromosome.
DR GO; GO:0008983; F:protein-glutamate O-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 1.10.155.10; Chemotaxis receptor methyltransferase CheR, N-terminal domain; 1.
DR Gene3D; 1.10.287.620; Helix Hairpins; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022642; CheR_C.
DR InterPro; IPR000780; CheR_MeTrfase.
DR InterPro; IPR022641; CheR_N.
DR InterPro; IPR036804; CheR_N_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; TIGR00229; sensory_box; 2.
DR PANTHER; PTHR24422; CHEMOTAXIS PROTEIN METHYLTRANSFERASE; 1.
DR PANTHER; PTHR24422:SF25; CONSERVED HYPOTHETICAL CHEMOTAXIS PROTEIN; 1.
DR Pfam; PF01739; CheR; 1.
DR Pfam; PF03705; CheR_N; 1.
DR Pfam; PF13188; PAS_8; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR00996; CHERMTFRASE.
DR SMART; SM00138; MeTrc; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47757; Chemotaxis receptor methyltransferase CheR, N-terminal domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50123; CHER; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..267
FT /note="CheR-type methyltransferase"
FT /evidence="ECO:0000259|PROSITE:PS50123"
FT DOMAIN 498..542
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT COILED 418..491
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 613 AA; 68852 MW; 62AD3B75D167DF7A CRC64;
MESTTDEAFE ALLRYMRDSR GFDFTGYKRT SLMRRVRRRM DQAGYTSFEE YLDFLQASSD
EFTALFNTIL INVTSFFRDA EAWDYVGAEV IPRLLAERGP DDPIRVWSAG CASGQEAYTL
AMMLAEALGA EEFRQRVKIY ATDVDEDALG EGRGASYDAK AVESVPPEML GRYFEQVNGR
YVFRKDLRRA VIFGRNDLVT DAPISRVDLL VCRNALMYLN AETQRNVLGR LHFALTPQGT
LFLGHAEMLL SHGDRFTPVS LKHRIFRKAA GTHVGADRYE PGGAFYERHA ELPGLATVRD
LAFRASPVAQ IVVTGEDIVA MINQQAETLF GLSARDIGRL LRDLEVSYRP VELRAYVEQA
KVERRPSRIQ DVKWQRPGTE TVWFEIHVNP LVDAENGLLG VSIVFFDVTA TRALLDKVVQ
TNRQLEAAYG ELQSTNEELE TTNEELQSTV EELETTNEEL QSTNEELETM NEELQSTNDE
LQTINDMLRE RSLELDEAKS FQDSLVDSIQ SGMVVVDREM KIVLWNRGCE DLWGLRADET
LGSRLTALDI GLPLDGVLPL IGNAFVDPDT SGEVVVDAVN RRGRPARVRV TCTPFRSNIG
TVGGALLLME VLG
//