ID I2B8K4_SHIBC Unreviewed; 383 AA.
AC I2B8K4; K6WL95;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=S-adenosyl-L-homocysteine hydrolase {ECO:0000313|EMBL:AFJ46858.1};
GN OrderedLocusNames=EBL_c17640 {ECO:0000313|EMBL:AFJ46858.1};
OS Shimwellia blattae (strain ATCC 29907 / DSM 4481 / JCM 1650 / NBRC 105725 /
OS CDC 9005-74) (Escherichia blattae).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shimwellia.
OX NCBI_TaxID=630626 {ECO:0000313|EMBL:AFJ46858.1, ECO:0000313|Proteomes:UP000001955};
RN [1] {ECO:0000313|EMBL:AFJ46858.1, ECO:0000313|Proteomes:UP000001955}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29907 / DSM 4481 / JCM 1650 / NBRC 105725 / CDC 9005-74
RC {ECO:0000313|Proteomes:UP000001955};
RX PubMed=22843577; DOI=10.1128/JB.00829-12;
RA Brzuszkiewicz E., Waschkowitz T., Wiezer A., Daniel R.;
RT "Complete genome sequence of the B12-producing Shimwellia blattae strain
RT DSM 4481, isolated from a cockroach.";
RL J. Bacteriol. 194:4436-4436(2012).
CC -!- COFACTOR:
CC Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC Evidence={ECO:0000256|ARBA:ARBA00001911};
CC -!- SIMILARITY: Belongs to the adenosylhomocysteinase family.
CC {ECO:0000256|ARBA:ARBA00007122}.
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DR EMBL; CP001560; AFJ46858.1; -; Genomic_DNA.
DR RefSeq; WP_002443976.1; NZ_BAHA01000024.1.
DR AlphaFoldDB; I2B8K4; -.
DR STRING; 630626.EBL_c17640; -.
DR KEGG; ebt:EBL_c17640; -.
DR PATRIC; fig|630626.3.peg.1706; -.
DR eggNOG; COG0499; Bacteria.
DR HOGENOM; CLU_025194_0_2_6; -.
DR OrthoDB; 9802717at2; -.
DR Proteomes; UP000001955; Chromosome.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1480; Adenosylhomocysteinase-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR042172; Adenosylhomocyst_ase-like_sf.
DR InterPro; IPR000043; Adenosylhomocysteinase-like.
DR InterPro; IPR015878; Ado_hCys_hydrolase_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23420; ADENOSYLHOMOCYSTEINASE; 1.
DR PANTHER; PTHR23420:SF0; ADENOSYLHOMOCYSTEINASE; 1.
DR Pfam; PF05221; AdoHcyase; 1.
DR Pfam; PF00670; AdoHcyase_NAD; 1.
DR SMART; SM00996; AdoHcyase; 1.
DR SMART; SM00997; AdoHcyase_NAD; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:AFJ46858.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001955}.
FT DOMAIN 165..328
FT /note="S-adenosyl-L-homocysteine hydrolase NAD binding"
FT /evidence="ECO:0000259|SMART:SM00997"
SQ SEQUENCE 383 AA; 42080 MW; 5C97B38CC0F02ACF CRC64;
MTSRIEWVRN NCRLLKQLSA EYKKTQPFKG LTIGTGIHLE PKTVTLLLTL KEGGARVVST
GNLNSTQKSA VDYLREHGVE VIGDVTRDKT QHLKYLQAVL AEKPDLLLDN GGDLFAEYLK
APYDNLKGGT EETTSGRMRL VALRQQLNMP ILVINDSPIK QFAENEHAVG QSVLESYMRI
TNRVTNGQRV TVFGYGACGM GVAYNFRSAN AKVSVVDTDP LKRLQAHLDG FDTPSREDAI
RSADVIITVS GGGRIIGGED IPLLKDGVIL ANAGHFPVEI DVDSFARSAQ IENAHEFEES
IASYQTKSGK NFKIIAEGHM FNLAGPRPLG NSIESMDMGF ALQSLCLEAV ARGKVNNTHC
VVPVTREIDE RVANMYIDLI YTK
//
