ID I2BCP4_SHIBC Unreviewed; 318 AA.
AC I2BCP4; K6VFM7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=2-keto-3-deoxygluconate permease {ECO:0000256|HAMAP-Rule:MF_00070};
DE Short=KDG permease {ECO:0000256|HAMAP-Rule:MF_00070};
GN Name=kdgT2 {ECO:0000313|EMBL:AFJ48298.1};
GN Synonyms=kdgT {ECO:0000256|HAMAP-Rule:MF_00070};
GN OrderedLocusNames=EBL_c32350 {ECO:0000313|EMBL:AFJ48298.1};
OS Shimwellia blattae (strain ATCC 29907 / DSM 4481 / JCM 1650 / NBRC 105725 /
OS CDC 9005-74) (Escherichia blattae).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shimwellia.
OX NCBI_TaxID=630626 {ECO:0000313|EMBL:AFJ48298.1, ECO:0000313|Proteomes:UP000001955};
RN [1] {ECO:0000313|EMBL:AFJ48298.1, ECO:0000313|Proteomes:UP000001955}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29907 / DSM 4481 / JCM 1650 / NBRC 105725 / CDC 9005-74
RC {ECO:0000313|Proteomes:UP000001955};
RX PubMed=22843577; DOI=10.1128/JB.00829-12;
RA Brzuszkiewicz E., Waschkowitz T., Wiezer A., Daniel R.;
RT "Complete genome sequence of the B12-producing Shimwellia blattae strain
RT DSM 4481, isolated from a cockroach.";
RL J. Bacteriol. 194:4436-4436(2012).
CC -!- FUNCTION: Catalyzes the proton-dependent uptake of 2-keto-3-
CC deoxygluconate (KDG) into the cell. {ECO:0000256|HAMAP-Rule:MF_00070}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-dehydro-3-deoxy-D-gluconate(in) + H(+)(in) = 2-dehydro-3-
CC deoxy-D-gluconate(out) + H(+)(out); Xref=Rhea:RHEA:29943,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57990; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_00070};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000256|HAMAP-
CC Rule:MF_00070}; Multi-pass membrane protein {ECO:0000256|HAMAP-
CC Rule:MF_00070}.
CC -!- SIMILARITY: Belongs to the KdgT transporter family.
CC {ECO:0000256|ARBA:ARBA00006430, ECO:0000256|HAMAP-Rule:MF_00070}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_00070}.
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DR EMBL; CP001560; AFJ48298.1; -; Genomic_DNA.
DR RefSeq; WP_002464011.1; NZ_BAHA01000011.1.
DR AlphaFoldDB; I2BCP4; -.
DR STRING; 630626.EBL_c32350; -.
DR KEGG; ebt:EBL_c32350; -.
DR PATRIC; fig|630626.3.peg.3147; -.
DR eggNOG; ENOG502Z7JT; Bacteria.
DR HOGENOM; CLU_057476_0_0_6; -.
DR OrthoDB; 3185611at2; -.
DR Proteomes; UP000001955; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015649; F:2-keto-3-deoxygluconate:proton symporter activity; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00070; KdgT; 1.
DR InterPro; IPR004684; 2keto-3dGluconate_permease.
DR Pfam; PF03812; KdgT; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|HAMAP-Rule:MF_00070};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_00070};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00070};
KW Reference proteome {ECO:0000313|Proteomes:UP000001955};
KW Sugar transport {ECO:0000256|HAMAP-Rule:MF_00070};
KW Symport {ECO:0000256|HAMAP-Rule:MF_00070};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_00070};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_00070};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_00070}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 45..64
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 71..90
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 134..155
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 161..182
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 189..209
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 247..268
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
FT TRANSMEM 280..300
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00070"
SQ SEQUENCE 318 AA; 31676 MW; 8EAF212C016C39D3 CRC64;
MNLKQAIEKI PGGMMVVPLV CGALLNTFTP GALEIGGFTS ALFKQGAPAL IGAFLLCMGA
GISVKAAPQA LLQGGTITLT KLLVAIVLGL GVEKLFGAQG LFGLSGVALI AAMSNSNGGL
YAALVGEFGN ERDVGAISIL SLNDGPFFTL IALGAAGMAN IPLIALVAVL VPLVVGMTLG
NLDPQMRDFL TRGGPVLIPF FAFALGAGIN LETLLQGGMA GILLGVLTTF IGGWFTIRAD
RLVGGSGIAG AAASSTAGNA VATPLAIAQA DPALAEVAAS AAPLIATSVI TTAILTPLLT
SRVAKRYAAR PAQGGEKA
//
