ID I2BD53_SHIBC Unreviewed; 488 AA.
AC I2BD53; K6WLE5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE SubName: Full=5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase {ECO:0000313|EMBL:AFJ48457.1};
GN Name=hpcC {ECO:0000313|EMBL:AFJ48457.1};
GN OrderedLocusNames=EBL_c33970 {ECO:0000313|EMBL:AFJ48457.1};
OS Shimwellia blattae (strain ATCC 29907 / DSM 4481 / JCM 1650 / NBRC 105725 /
OS CDC 9005-74) (Escherichia blattae).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Shimwellia.
OX NCBI_TaxID=630626 {ECO:0000313|EMBL:AFJ48457.1, ECO:0000313|Proteomes:UP000001955};
RN [1] {ECO:0000313|EMBL:AFJ48457.1, ECO:0000313|Proteomes:UP000001955}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29907 / DSM 4481 / JCM 1650 / NBRC 105725 / CDC 9005-74
RC {ECO:0000313|Proteomes:UP000001955};
RX PubMed=22843577; DOI=10.1128/JB.00829-12;
RA Brzuszkiewicz E., Waschkowitz T., Wiezer A., Daniel R.;
RT "Complete genome sequence of the B12-producing Shimwellia blattae strain
RT DSM 4481, isolated from a cockroach.";
RL J. Bacteriol. 194:4436-4436(2012).
CC -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC {ECO:0000256|RuleBase:RU003345}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001560; AFJ48457.1; -; Genomic_DNA.
DR RefSeq; WP_002444087.1; NZ_BAHA01000026.1.
DR AlphaFoldDB; I2BD53; -.
DR STRING; 630626.EBL_c33970; -.
DR KEGG; ebt:EBL_c33970; -.
DR PATRIC; fig|630626.3.peg.3308; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_0_2_6; -.
DR OrthoDB; 9812625at2; -.
DR Proteomes; UP000001955; Chromosome.
DR GO; GO:0018480; F:5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity; IEA:InterPro.
DR GO; GO:1901023; P:4-hydroxyphenylacetate catabolic process; IEA:InterPro.
DR CDD; cd07093; ALDH_F8_HMSADH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR029510; Ald_DH_CS_GLU.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR011985; DH_HpaE.
DR NCBIfam; TIGR02299; HpaE; 1.
DR PANTHER; PTHR43720; 2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43720:SF2; 2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003345};
KW Reference proteome {ECO:0000313|Proteomes:UP000001955}.
FT DOMAIN 18..474
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT ACT_SITE 244
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10007"
SQ SEQUENCE 488 AA; 53062 MW; 3974770C9572D850 CRC64;
MKTINHWING KNVPGRDYFQ TTNPATGEVL ADVASGGEAE INQAVAAAKE AFPKWAGLPM
KERARLMRKL GELIDENVPD IAAMETADTG LPIHQTRNVL IPRASHNFEF FAEVCQQMNG
KTYPVDDKML NYTLVQPVGV CALVSPWNVP FMTATWKVAP CLALGNTAVL KMSELSPLTA
DRLGELALEA GIPAGVLNVV QGYGATAGDA LVRHHDVRAV SFTGGTATGR RIMQNAGLKK
YSMELGGKSP VLVFEDADIE RALDAALFTI FSINGERCTA GSRIFIQQSI YPEFVKRFAE
RANRLRVGDP TDPATQVGAL ISQQHWDKVS GYIRIGIEEG ATLLAGGPDK PADLPPHLRN
GNFLRPTVLA DVDNRMRVAQ EEIFGPVACL IPFKDEAEGL RLANDVEYGL ASYIWTQDVS
KVLRLARGIE AGMVFVNTQN VRDLRQPFGG VKASGTGREG GEYSFEVFAE MKNVCISLGD
HPIPKWGV
//
