ID I2BJH9_PLAFA Unreviewed; 277 AA.
AC I2BJH9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Merozoite surface protein 1 {ECO:0000256|ARBA:ARBA00022062};
DE AltName: Full=Merozoite surface antigen {ECO:0000256|ARBA:ARBA00031689};
DE AltName: Full=PMMSA {ECO:0000256|ARBA:ARBA00032276};
DE Flags: Fragment;
GN Name=MSP-1 {ECO:0000313|EMBL:AFJ54125.1};
OS Plasmodium falciparum (malaria parasite P. falciparum).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=5833 {ECO:0000313|EMBL:AFJ54125.1};
RN [1] {ECO:0000313|EMBL:AFJ54125.1}
RP NUCLEOTIDE SEQUENCE.
RA Viputtigul K., Tungpukdee N., Ruang-Areerate T., Luplertlop N.,
RA Wilairatana P., Gaywee J., Krudsood S.;
RT "C-terminus polymorphism of merozoite surface protein-1 (MSP-1) of
RT Plasmodium falciparium isolates causing infection in western border of
RT Thailand, Tak province.";
RL Southeast Asian J. Trop. Med. Public Health 0:0-0(2013).
CC -!- FUNCTION: By binding to host proinflammatory cytokine S100P may
CC interfere with host immune responses. {ECO:0000256|ARBA:ARBA00043850}.
CC -!- SUBUNIT: Interacts with host SLC4A1/Band 3 (via 5ABC region) on the
CC host erythrocyte surface in a sialic acid-independent manner.
CC {ECO:0000256|ARBA:ARBA00044022}.
CC -!- SUBUNIT: Interacts with host glycophorin GYPA in a sialic acid-
CC independent manner. {ECO:0000256|ARBA:ARBA00044006}.
CC -!- SUBUNIT: Interacts with host proinflammatory cytokine S100P; the
CC interaction blocks S100P inflammatory and chemotactic activities.
CC {ECO:0000256|ARBA:ARBA00044008}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}. Vacuole membrane
CC {ECO:0000256|ARBA:ARBA00043950}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00043950}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JQ664279; AFJ54125.1; -; Genomic_DNA.
DR AlphaFoldDB; I2BJH9; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR010901; MSP1_C.
DR InterPro; IPR024730; MSP1_EGF_1.
DR Pfam; PF12946; EGF_MSP1_1; 1.
DR Pfam; PF07462; MSP1_C; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
PE 4: Predicted;
KW Merozoite {ECO:0000313|EMBL:AFJ54125.1};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Vacuole {ECO:0000256|ARBA:ARBA00022554}.
FT DOMAIN 1..156
FT /note="Merozoite surface 1 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07462"
FT DOMAIN 232..268
FT /note="Merozoite surface protein EGF"
FT /evidence="ECO:0000259|Pfam:PF12946"
FT REGION 90..111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFJ54125.1"
FT NON_TER 277
FT /evidence="ECO:0000313|EMBL:AFJ54125.1"
SQ SEQUENCE 277 AA; 32181 MW; 52A9EFA25689DC4F CRC64;
LKKRKYFLDV LESDLMQFKH ISSNEYIIED SFKLLNSEQK NTLLKSYKYI KESVENDIKF
AQEGISYYEK VLAKYKDDLE SIKKVIKEEK EKFPSSPPTT PPSPAKTDEQ KKESKFLPFL
TNIETLYNNL VNKIDDYLIN LKAKINDCNV EKNEAHVKIT KLSDLKAIDD KIDLFKNTND
FEAIKKLIND DTKKDMLGKL LSTGLVQNFP NTIISKLIEG KFQDMLNISQ HQCVKKQCPE
NSGCFRHLDE REECKCLLNY KQEGDKCVEN PNPTCNE
//
