ID I2CCH2_9METZ Unreviewed; 173 AA.
AC I2CCH2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=6-phosphofructokinase {ECO:0000256|ARBA:ARBA00012055};
DE EC=2.7.1.11 {ECO:0000256|ARBA:ARBA00012055};
DE Flags: Fragment;
GN Name=PFK {ECO:0000313|EMBL:AFJ64346.1};
OS Placospongia intermedia.
OC Eukaryota; Metazoa; Porifera; Demospongiae; Heteroscleromorpha; Clionaida;
OC Placospongiidae; Placospongia.
OX NCBI_TaxID=1131261 {ECO:0000313|EMBL:AFJ64346.1};
RN [1] {ECO:0000313|EMBL:AFJ64346.1}
RP NUCLEOTIDE SEQUENCE.
RA Hill M., Hill A., Lopez J., Reed J., Tarver J., Pomponi S., Redmond N.,
RA Diaz C., Cardenas P., Boury-Esnault N., Reiswig H., Dohrmann M., Morrow C.,
RA Rubin E., Chaves-Fonnegra A., Patel J., Formica D., Danka E., De Laine B.,
RA Pohlmann D., Richie S., Stefano M., Russell Z., Peterson K., Pisani D.,
RA Thacker R., Collins A.;
RT "Nuclear housekeeping genes help resolve demosponge relationships and
RT taxonomy.";
RL Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-
CC bisphosphate + H(+); Xref=Rhea:RHEA:16109, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:32966, ChEBI:CHEBI:57634,
CC ChEBI:CHEBI:456216; EC=2.7.1.11;
CC Evidence={ECO:0000256|ARBA:ARBA00000432};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 3/4.
CC {ECO:0000256|ARBA:ARBA00004679}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; JQ606664; AFJ64346.1; -; mRNA.
DR AlphaFoldDB; I2CCH2; -.
DR UniPathway; UPA00109; UER00182.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0003872; F:6-phosphofructokinase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006002; P:fructose 6-phosphate metabolic process; IEA:InterPro.
DR Gene3D; 3.40.50.450; -; 1.
DR Gene3D; 3.40.50.460; Phosphofructokinase domain; 1.
DR InterPro; IPR022953; ATP_PFK.
DR InterPro; IPR000023; Phosphofructokinase_dom.
DR InterPro; IPR035966; PKF_sf.
DR PANTHER; PTHR13697:SF4; ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE; 1.
DR PANTHER; PTHR13697; PHOSPHOFRUCTOKINASE; 1.
DR Pfam; PF00365; PFK; 1.
DR PRINTS; PR00476; PHFRCTKINASE.
DR SUPFAM; SSF53784; Phosphofructokinase; 1.
PE 2: Evidence at transcript level;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycolysis {ECO:0000256|ARBA:ARBA00023152};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AFJ64346.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..173
FT /note="Phosphofructokinase"
FT /evidence="ECO:0000259|Pfam:PF00365"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AFJ64346.1"
FT NON_TER 173
FT /evidence="ECO:0000313|EMBL:AFJ64346.1"
SQ SEQUENCE 173 AA; 18723 MW; 1E8A5BD6CBAEF466 CRC64;
ALRAIVRVAI FNGLKAYAIC DGYQGMVEGG DKIKEMTWSS VSNIIHRGGT VIGTARCKEF
RERSGRLKAA RNLIKRGINS LGIIGGDGTL TGANIFKQEW KDLVKELVET GQVSQEEAEK
CSYLNIAGLV GSIDNDMCGT NMTIGTDSCL HRILEAIDCL NSTAASHQRS FVL
//
