ID I2CUE5_MACMU Unreviewed; 463 AA.
AC I2CUE5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 60.
DE SubName: Full=Rho guanine nucleotide exchange factor 9 isoform 2 {ECO:0000313|EMBL:AFJ70580.1};
GN Name=ARHGEF9 {ECO:0000313|EMBL:AFJ70580.1};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|EMBL:AFJ70580.1};
RN [1] {ECO:0000313|EMBL:AFJ70580.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:AFJ70580.1};
RX PubMed=25319552; DOI=10.1186/1745-6150-9-20;
RA Zimin A.V., Cornish A.S., Maudhoo M.D., Gibbs R.M., Zhang X., Pandey S.,
RA Meehan D.T., Wipfler K., Bosinger S.E., Johnson Z.P., Tharp G.K.,
RA Marcais G., Roberts M., Ferguson B., Fox H.S., Treangen T., Salzberg S.L.,
RA Yorke J.A., Norgren R.B.Jr.;
RT "A new rhesus macaque assembly and annotation for next-generation
RT sequencing analyses.";
RL Biol. Direct 9:20-20(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; JV600192; AFJ70580.1; -; mRNA.
DR RefSeq; XP_014983061.1; XM_015127575.1.
DR AlphaFoldDB; I2CUE5; -.
DR SMR; I2CUE5; -.
DR GeneID; 707387; -.
DR CTD; 23229; -.
DR OrthoDB; 24739at2759; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01224; PH_Collybistin_ASEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR47544:SF1; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 4; 1.
DR PANTHER; PTHR47544; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT DOMAIN 50..234
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 265..372
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 400..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 54965 MW; 046F5EC27274EC71 CRC64;
MQWIRGGSGM LWVNQEDEVE EGPSDVQNGH LDPNSDCLCL GRPLQNRDQM RANVINEIMS
TERHYIKHLK DICEGYLKQC RKRRDMFSDE QLKVIFGNIE DIYRFQMGFV RDLEKQYNND
DPHLSEIGPC FLEHQDGFWI YSEYCNNHLD ACMELSKLMK DSRYQHFFEA CRLLQQMIDI
AIDGFLLTPV QKICKYPLQL AELLKYTAQD HSDYRYVAAA LAVMRNVTQQ INERKRRLEN
IDKIAQWQAS VLDWEGEDIL DRSSELIYTG EMAWIYQPYG RNQQRVFFLF DHQMVLCKKD
LIRRDILYYK GRIDMDKYEV VDIEDGRDDD FNVSMKNAFK LHNKETEEIH LFFAKKLEEK
IRWLRAFREE RKMVQEDEKI GFEISENQKR QAAMTVRKVP KQKGVNSARS VPPSYPPPQD
PLNHGQYLVP DGIAQSQVFE FTEPKRSQSP FWQNFSRLTP FKK
//