ID I2F245_9BACT Unreviewed; 279 AA.
AC I2F245;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Geranylgeranyl pyrophosphate synthase {ECO:0000313|EMBL:AFK05998.1};
GN ORFNames=Theba_0265 {ECO:0000313|EMBL:AFK05998.1};
OS Mesotoga prima MesG1.Ag.4.2.
OC Bacteria; Thermotogota; Thermotogae; Kosmotogales; Kosmotogaceae; Mesotoga.
OX NCBI_TaxID=660470 {ECO:0000313|EMBL:AFK05998.1, ECO:0000313|Proteomes:UP000002881};
RN [1] {ECO:0000313|EMBL:AFK05998.1, ECO:0000313|Proteomes:UP000002881}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=mesG1.Ag.4.2 {ECO:0000313|Proteomes:UP000002881};
RX PubMed=22798451;
RA Zhaxybayeva O., Swithers K.S., Foght J., Green A.G., Bruce D., Detter C.,
RA Han S., Teshima H., Han J., Woyke T., Pitluck S., Nolan M., Ivanova N.,
RA Pati A., Land M.L., Dlutek M., Doolittle W.F., Noll K.M., Nesbo C.L.;
RT "Genome Sequence of the Mesophilic Thermotogales Bacterium Mesotoga prima
RT MesG1.Ag.4.2 Reveals the Largest Thermotogales Genome To Date.";
RL Genome Biol. Evol. 4:700-708(2012).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the FPP/GGPP synthase family.
CC {ECO:0000256|RuleBase:RU004466}.
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DR EMBL; CP003532; AFK05998.1; -; Genomic_DNA.
DR RefSeq; WP_014730156.1; NC_017934.1.
DR AlphaFoldDB; I2F245; -.
DR STRING; 660470.Theba_0265; -.
DR KEGG; mpg:Theba_0265; -.
DR eggNOG; COG0142; Bacteria.
DR HOGENOM; CLU_014015_0_1_0; -.
DR Proteomes; UP000002881; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.
DR CDD; cd00685; Trans_IPPS_HT; 1.
DR Gene3D; 1.10.600.10; Farnesyl Diphosphate Synthase; 1.
DR InterPro; IPR008949; Isoprenoid_synthase_dom_sf.
DR InterPro; IPR000092; Polyprenyl_synt.
DR InterPro; IPR033749; Polyprenyl_synt_CS.
DR PANTHER; PTHR43281; FARNESYL DIPHOSPHATE SYNTHASE; 1.
DR PANTHER; PTHR43281:SF1; FARNESYL DIPHOSPHATE SYNTHASE; 1.
DR Pfam; PF00348; polyprenyl_synt; 1.
DR SFLD; SFLDS00005; Isoprenoid_Synthase_Type_I; 1.
DR SFLD; SFLDG01017; Polyprenyl_Transferase_Like; 1.
DR SUPFAM; SSF48576; Terpenoid synthases; 1.
DR PROSITE; PS00723; POLYPRENYL_SYNTHASE_1; 1.
DR PROSITE; PS00444; POLYPRENYL_SYNTHASE_2; 1.
PE 3: Inferred from homology;
KW Isoprene biosynthesis {ECO:0000256|ARBA:ARBA00023229};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000002881};
KW Transferase {ECO:0000256|RuleBase:RU004466}.
SQ SEQUENCE 279 AA; 31996 MW; F65A3A3C86F506EF CRC64;
MKLAEFSPFF NCKLKNFLDE LHISKPFKDV VSYTPLAGGK RLRAYLIWEL SRYTGFGEEN
ALKAGIAVEL FHSGSLIHDD LPAIDNDTIR RGLPSSHIKF GESKAILAGD FLMLFPGRVF
SSLDLETRYI HPILELWQET SLKVVEGEFD DVFPEDESRE QMERIHAAKT GALFGFCFAA
PFIREKREKI DEMYKLGVRF GKLYQMMDDI KDVISTESEL GKTPGKDGKQ NKLTILSFES
LEEAQIEVKE SFHSILGEID SFTDLKKEMR DIYYLIARR
//
