ID I2GY68_TETBL Unreviewed; 627 AA.
AC I2GY68;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=PUM-HD domain-containing protein {ECO:0000259|PROSITE:PS50303};
GN Name=TBLA0B02280 {ECO:0000313|EMBL:CCH59070.1};
GN ORFNames=TBLA_0B02280 {ECO:0000313|EMBL:CCH59070.1};
OS Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH59070.1, ECO:0000313|Proteomes:UP000002866};
RN [1] {ECO:0000313|EMBL:CCH59070.1, ECO:0000313|Proteomes:UP000002866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
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DR EMBL; HE806317; CCH59070.1; -; Genomic_DNA.
DR RefSeq; XP_004178589.1; XM_004178541.1.
DR AlphaFoldDB; I2GY68; -.
DR STRING; 1071380.I2GY68; -.
DR GeneID; 14494254; -.
DR KEGG; tbl:TBLA_0B02280; -.
DR eggNOG; KOG2050; Eukaryota.
DR HOGENOM; CLU_013994_1_0_1; -.
DR InParanoid; I2GY68; -.
DR OMA; YGPEFSI; -.
DR OrthoDB; 5479527at2759; -.
DR Proteomes; UP000002866; Chromosome 2.
DR GO; GO:0003729; F:mRNA binding; IEA:UniProt.
DR GO; GO:0017148; P:negative regulation of translation; IEA:UniProt.
DR GO; GO:0065008; P:regulation of biological quality; IEA:UniProt.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR012959; CPL_dom.
DR InterPro; IPR033133; PUM-HD.
DR InterPro; IPR040059; PUM3.
DR InterPro; IPR001313; Pumilio_RNA-bd_rpt.
DR PANTHER; PTHR13389:SF0; PUMILIO HOMOLOG 3; 1.
DR PANTHER; PTHR13389; UNCHARACTERIZED; 1.
DR Pfam; PF08144; CPL; 1.
DR Pfam; PF00806; PUF; 3.
DR SMART; SM00025; Pumilio; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50302; PUM; 3.
DR PROSITE; PS50303; PUM_HD; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002866};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT REPEAT 146..182
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT DOMAIN 160..536
FT /note="PUM-HD"
FT /evidence="ECO:0000259|PROSITE:PS50303"
FT REPEAT 183..218
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REPEAT 219..255
FT /note="Pumilio"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00317"
FT REGION 1..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..57
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..86
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 627 AA; 72711 MW; 6FB8F18D7DD28C3A CRC64;
MTTIKKKQNS SKRSLKESKD SKKIKKARIS IESSDDDLDF ISDEEHANDK DVSEQEEEVN
DAKSDEESED QNDEDSGEES NEDTPTSNDD SNDNHTEQRK LLKERKLQRK SGIQVQQIKQ
LWEKLRVKSP PIPKEIRNKL CGEIWELSKD CIKDLIMKHD SSRVVQTLVK YCDKERREQI
VQSLKGNYYV LATSAYGKYL LVKLLHYGTK DSRQIIIDEL HGSLRKLMRH REGAYVVEDL
FVLYASHEQK QQMIKEFWGA EYAVFKDSYK NEDIKQVCKN TEKRDIIAKN LIGTISASIN
KGSTGFQILH AAMREYIKIM NDEECSEMIE LLHEQIAELV HTPEGCEVAC VLIARGNAKE
RKSIIRGLKA HGSKLMQNEY GNLILITLFM TVDDTVLMFK TFGPVLKENF VEIICDKYGR
RPFLYLLKEL NGKYFYPQIK KDLLKYKEMS QSKKDDKQRR LELLDKFGSL ILSQLNKNFE
DIIENNLGIQ MIQEVLQCER IYEEDKIATL IEKIIKTGMK DDSMYCRLLK SLIQGGCWNN
QLKQLEPFKK IENLVGVEFG VKLFNEVIEG NILEWIENED CSFCIVSLYE TLHGKKEGEG
FEKELKEVDL QNVESKGGKL LLKLMNN
//
