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Database: UniProt
Entry: I2H0Q6_TETBL
LinkDB: I2H0Q6_TETBL
Original site: I2H0Q6_TETBL 
ID   I2H0Q6_TETBL            Unreviewed;       906 AA.
AC   I2H0Q6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   07-JUN-2017, entry version 23.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=TBLA0C01430 {ECO:0000313|EMBL:CCH59958.1};
GN   ORFNames=TBLA_0C01430 {ECO:0000313|EMBL:CCH59958.1};
OS   Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 /
OS   NBRC 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae;
OC   Tetrapisispora.
OX   NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH59958.1, ECO:0000313|Proteomes:UP000002866};
RN   [1] {ECO:0000313|EMBL:CCH59958.1, ECO:0000313|Proteomes:UP000002866}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC   UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX   PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA   Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S.,
RA   Byrne K.P., Wolfe K.H.;
RT   "Evolutionary erosion of yeast sex chromosomes by mating-type
RT   switching accidents.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; HE806318; CCH59958.1; -; Genomic_DNA.
DR   RefSeq; XP_004179477.1; XM_004179429.1.
DR   EnsemblFungi; CCH59958; CCH59958; TBLA_0C01430.
DR   GeneID; 14494938; -.
DR   KEGG; tbl:TBLA_0C01430; -.
DR   InParanoid; I2H0Q6; -.
DR   KO; K02154; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000002866; Chromosome 3.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005770; C:late endosome; IEA:EnsemblFungi.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:EnsemblFungi.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:EnsemblFungi.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0007035; P:vacuolar acidification; IEA:EnsemblFungi.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002866};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002866};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    474    498       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    519    536       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    596    616       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    628    649       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    689    708       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    841    863       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      117    151       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   906 AA;  104397 MW;  100F4A0AC371551B CRC64;
     MSHEESIYRS APMTYVQLYI PLETSKEVVS LFGRLGNIMF RDMNTQLNSF QRGYVSQLRK
     YEDIERLVTY LKDISKKYSG ATWKYFLHYN EEGNEIVQPD LNTNLYQTLD RINQENINEL
     IHDIQGFELR VRQLNDSMDD LQLKLNNFIE QRHVFFQCRR FLEINPGIVG RISRERRDRL
     DVDDFRLNST DDINNADAIS ETLSDAFSFD NPTQQLTTYQ DTNNIDEFSD DNYGFLEQGL
     HDKFMIAGSI NRTKVEILNR ILWRLLRGNL YFQNFPIEEP LIDDSAKNSN EKIEKDSFII
     FTHGETLLNK AKRVIDSLDG KVYPLRNTNS QTINQLNDRI SELQQIVTTT EQTLHTELLV
     VNDQLPLWSA LVKREKYIYA TLNLFRRESH GLVAEGWIPS SEVTLVSNSL KDHSESIGSE
     YTPVLNIIKT NKSPPTYYRT NKFTKGFQAI VDAYGVSTYR EINPGLATIV TFPFLFAIMF
     GDTGHGFILF LIAIYFIINE SKFDNMRRDE IFDMAYSGRY VLVLMGGFSI YTGILYNDIF
     SKSMTLFNSG WKWPEHFKEG DAIEATQIGV YPFGLDWAWH GTDNSLLFTN SYKMKLSILI
     GFIHMTYSFC FSYINYKNNN SRVDIIGNFI PGLIFMQSIF GYLSITIVYK WSKDWIKDGK
     PAPGLLNMLI NMFLSPGVID EQLYPGQGII QKLLLIFALV CVPWLLLYKP LTLRKQNSRA
     VQLGYQDIND QRINESILDS QATAGDEMII TDFSTNETSN ENAGSYDDNE NKDEPKGFQF
     GDVMIHQVIH TIEFCLNCIS HTASYLRLWA LSLAHAQLST VLWDMTISNA FSSKNSGSPL
     AVAKVVFLFG MWFVLTVCIL VLMEGTSAML HALRLIWVEA MSKFFEGEGY AYEPFTFAHL
     EDDDEQ
//
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