ID I2H1D1_TETBL Unreviewed; 1069 AA.
AC I2H1D1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE RecName: Full=ISWI chromatin-remodeling complex ATPase ISW2 {ECO:0008006|Google:ProtNLM};
GN Name=TBLA0C03810 {ECO:0000313|EMBL:CCH60183.1};
GN ORFNames=TBLA_0C03810 {ECO:0000313|EMBL:CCH60183.1};
OS Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH60183.1, ECO:0000313|Proteomes:UP000002866};
RN [1] {ECO:0000313|EMBL:CCH60183.1, ECO:0000313|Proteomes:UP000002866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.
CC {ECO:0000256|ARBA:ARBA00009687}.
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DR EMBL; HE806318; CCH60183.1; -; Genomic_DNA.
DR RefSeq; XP_004179702.1; XM_004179654.1.
DR AlphaFoldDB; I2H1D1; -.
DR STRING; 1071380.I2H1D1; -.
DR GeneID; 14495163; -.
DR KEGG; tbl:TBLA_0C03810; -.
DR eggNOG; KOG0385; Eukaryota.
DR HOGENOM; CLU_000315_0_2_1; -.
DR InParanoid; I2H1D1; -.
DR OMA; EFQFRES; -.
DR OrthoDB; 5482994at2759; -.
DR Proteomes; UP000002866; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140658; F:ATP-dependent chromatin remodeler activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0031491; F:nucleosome binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:UniProt.
DR CDD; cd17997; DEXHc_SMARCA1_SMARCA5; 1.
DR CDD; cd00167; SANT; 1.
DR CDD; cd18793; SF2_C_SNF; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.10.1040.30; ISWI, HAND domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR044754; Isw1/2_DEXHc.
DR InterPro; IPR015194; ISWI_HAND-dom.
DR InterPro; IPR036306; ISWI_HAND-dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR InterPro; IPR015195; SLIDE.
DR InterPro; IPR038718; SNF2-like_sf.
DR InterPro; IPR000330; SNF2_N.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR PANTHER; PTHR45623:SF49; ISW-1; 1.
DR Pfam; PF09110; HAND; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF09111; SLIDE; 1.
DR Pfam; PF00176; SNF2-rel_dom; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF101224; HAND domain of the nucleosome remodeling ATPase ISWI; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51293; SANT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002866}.
FT DOMAIN 149..314
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 447..598
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT DOMAIN 837..890
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..653
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1026..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 810..837
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 627..652
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1069 AA; 123581 MW; 24E9A635F14C2189 CRC64;
MSEKSDYELA LEPFKEDMPP LDPESNKKRY LIKDGGKPHF DLDGTVKRFQ HLLGLSGLFR
HFIEGKAKKD DRFQRVLDIL DDDGNKKGKG RAGHQDKRRR KTETEEDAEL LKGETDGDEE
NLEFQFRESP GYIDGLLRSY QIQGVNWLIS LHKNGLAGIL ADEMGLGKTL QTITFLGYLR
YVEKKPGPFL VIAPKSTLNN WLREINKWTP DVNAFILQGD KVERSELIKT KLLECDFEIV
VASYEIIIRE KAAFRKIDWE YIVIDEAHRI KNEESMLSQV LREFSSRNRL LITGTPLQNN
LHELWALLNF LLPDIFSSSE DFDSWFSSNE SEEDQDKIVK QLHTVLQPFL LRRIKSDVET
SLLPKKELNL YVGMSNMQKK WYKQILEKDL DAVNGSNGNK ESKTRLLNIV MQLRKCCNHP
YLFDGAEPGP PYTTDEHLVY NSAKLNVLDK LLEKVKEEGS RVLIFSQMSR VLDIMEDYCY
FRGYEYCRID GQTAHEDRIA AIDEYNAPDS SKFIFLLTTR AGGLGINLTT ADIVVLFDSD
WNPQADLQAM DRAHRIGQKK QVKVYRFVTD NSVEEKILER ATQKLKLDQL VIQQNRTSTQ
KKKQKEKQNE QKDALLSMIQ HGAADVFKSG NTSTGSSARG TPHPSGTTSG NDDAAEKEAI
DLESILELSE GKTQSLNQKY ATLGLDDLQK FNQDSAYEWN GTDFKKKTVE KDIISPLWIN
PTKRERKENY NIDGYYKDVL NTGKTTTPTQ PRMPKPHAFN SHQFQPPQLK VLYEKERMWT
AKKTGYKPTM EDVKNTYGEI EEEEKKKQLL ELLNLSIHNA QELSEEEKQE KLELEKKGFT
NWNKIEFRKF ISASGKYGRN SIQAIAMELS GTKTLEEVRE YAKAFWKNIE QIEDYEKYLK
SIEVEEEKIR RVKFQQEALR RKLSQCKAPL FDLSLKFPPS SSNKRTYSEE EDRFILLMLF
KYGLDRDDVY ELIRDEIRDS PLFELDFFFQ SRTPTELARR GYTLLQCLEK EFNSSIVMDE
ETKLRMKNED EEGSKVREEM GEASGANGTS ETSETSGTTD GHIDKKMKV
//