ID I2H8B1_TETBL Unreviewed; 737 AA.
AC I2H8B1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Translation initiation factor eIF2B subunit epsilon {ECO:0000256|ARBA:ARBA00044144};
DE AltName: Full=eIF2B GDP-GTP exchange factor subunit epsilon {ECO:0000256|ARBA:ARBA00044345};
GN Name=TBLA0H03320 {ECO:0000313|EMBL:CCH62613.1};
GN ORFNames=TBLA_0H03320 {ECO:0000313|EMBL:CCH62613.1};
OS Tetrapisispora blattae (strain ATCC 34711 / CBS 6284 / DSM 70876 / NBRC
OS 10599 / NRRL Y-10934 / UCD 77-7) (Yeast) (Kluyveromyces blattae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Tetrapisispora.
OX NCBI_TaxID=1071380 {ECO:0000313|EMBL:CCH62613.1, ECO:0000313|Proteomes:UP000002866};
RN [1] {ECO:0000313|EMBL:CCH62613.1, ECO:0000313|Proteomes:UP000002866}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 34711 / CBS 6284 / DSM 70876 / NBRC 10599 / NRRL Y-10934 /
RC UCD 77-7 {ECO:0000313|Proteomes:UP000002866};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the eIF-2B gamma/epsilon subunits family.
CC {ECO:0000256|ARBA:ARBA00007878}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; HE806323; CCH62613.1; -; Genomic_DNA.
DR RefSeq; XP_004182132.1; XM_004182084.1.
DR AlphaFoldDB; I2H8B1; -.
DR STRING; 1071380.I2H8B1; -.
DR GeneID; 14497840; -.
DR KEGG; tbl:TBLA_0H03320; -.
DR eggNOG; KOG1461; Eukaryota.
DR HOGENOM; CLU_012507_1_0_1; -.
DR InParanoid; I2H8B1; -.
DR OMA; LAQSCKI; -.
DR OrthoDB; 5474157at2759; -.
DR Proteomes; UP000002866; Chromosome 8.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0031369; F:translation initiation factor binding; IEA:InterPro.
DR GO; GO:0044271; P:cellular nitrogen compound biosynthetic process; IEA:UniProt.
DR CDD; cd04197; eIF-2B_epsilon_N; 1.
DR CDD; cd05787; LbH_eIF2B_epsilon; 1.
DR CDD; cd11558; W2_eIF2B_epsilon; 1.
DR Gene3D; 1.25.40.180; -; 1.
DR Gene3D; 2.160.10.10; Hexapeptide repeat proteins; 2.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035543; eIF-2B_epsilon_N.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR003307; W2_domain.
DR InterPro; IPR044123; W2_eIF2B_epsilon.
DR PANTHER; PTHR45887; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR PANTHER; PTHR45887:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR PROSITE; PS51363; W2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000002866}.
FT DOMAIN 558..729
FT /note="W2"
FT /evidence="ECO:0000259|PROSITE:PS51363"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 737 AA; 83525 MW; A7F37A7D8F4CEA48 CRC64;
MAAKKGKQNN NDNSSGGKQK GGSQNSKKGE MVPEDRLQAV VLTDCFQDRF MPLTATTPRC
LLPFGNVPLI EYTLEFLAKS GVNDVYIMCS AHAEQVSTYI ENSKWNLPWS PFKIQTIMSP
EARSVGDVMR DLDNRGIITD DFVLVSGDLI TNVEFDKLLE FHKFKHTQDK DHIMTMCLSK
AGQYYKKRSI EPATFILDKS NDRCIYYQDI PLQSAKSKTS VSIDPELLEN VDEFVLRNDL
IDCRIDICSP QVPPLFQDNF DYQTLRSDFV KGVISNDLLG KSVYAYITNE YAMRIDGWYS
YDFVSQDYLG RWVFPSVIES NLLEDQTYTH ESSHIYKEKD VVLAQSCKIG KCTAIGSKTT
IGEGTTIRNC VIGRNCKVGN NISIENSYIW ENAVIEDNCK INHCIVATNV KIGNNVTIND
GSIIGFNVVI DDNMEIPKDS KISSTPINKN NLFDSVLSDD DNSASEEDED ENANGKLAIN
LVGAKGIGYI YESELSDNDV DEYGSDDGKI INSLSNKFED IYLSDTSISS TTKKTKKKRS
ASISSVYTDR EEIGTDSEDE EEDFEKEGFA TVERAIENNH DLDTALLELN TLRMSMNVTY
HEVRTATISA LLSRVYHFIA TQTLGPKDAS LKVFNQWGLL FKRQCFEDAD FIDLMNILMT
KTLDQKFEKP DLILFTILNN LYDNDLLEED VIYKWWDTVS KDSKYDEVKK LTSKWVEWLR
NADEETSSEE DDDEEGD
//
