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Database: UniProt
Entry: I2HAA6_CAEEL
LinkDB: I2HAA6_CAEEL
Original site: I2HAA6_CAEEL 
ID   I2HAA6_CAEEL            Unreviewed;      5387 AA.
AC   I2HAA6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   30-AUG-2017, entry version 48.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:CCH63813.1};
GN   Name=unc-68 {ECO:0000313|EMBL:CCH63813.1,
GN   ECO:0000313|WormBase:K11C4.5c};
GN   ORFNames=CELE_K11C4.5 {ECO:0000313|EMBL:CCH63813.1}, K11C4.5
GN   {ECO:0000313|WormBase:K11C4.5c};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:CCH63813.1, ECO:0000313|Proteomes:UP000001940};
RN   [1] {ECO:0000313|EMBL:CCH63813.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCH63813.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
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DR   EMBL; BX284605; CCH63813.1; -; Genomic_DNA.
DR   RefSeq; NP_001256077.1; NM_001269148.1.
DR   UniGene; Cel.2066; -.
DR   ProteinModelPortal; I2HAA6; -.
DR   SMR; I2HAA6; -.
DR   EPD; I2HAA6; -.
DR   PaxDb; I2HAA6; -.
DR   PeptideAtlas; I2HAA6; -.
DR   EnsemblMetazoa; K11C4.5c; K11C4.5c; WBGene00006801.
DR   GeneID; 179080; -.
DR   CTD; 179080; -.
DR   WormBase; K11C4.5c; CE47589; WBGene00006801; unc-68.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; I2HAA6; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00006801; -.
DR   ExpressionAtlas; I2HAA6; baseline.
DR   GO; GO:0031674; C:I band; IDA:WormBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IDA:UniProtKB.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0040011; P:locomotion; IMP:WormBase.
DR   GO; GO:0043068; P:positive regulation of programmed cell death; IGI:WormBase.
DR   GO; GO:0033365; P:protein localization to organelle; IMP:WormBase.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|EPD:I2HAA6,
KW   ECO:0000213|PeptideAtlas:I2HAA6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4752   4775       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4938   4955       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5001   5023       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5139   5161       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5181   5206       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   5266   5285       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      102    156       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      163    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      216    271       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      277    334       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      342    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      580    801       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1004   1212       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1536   1755       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4498   4533       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4536   4568       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4511   4522       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4546   4557       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   COILED     4785   4807       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5387 AA;  612812 MW;  AD5728B58D6AEC2B CRC64;
     MDFDFTDISD EDHNYVTKGD IVCLSCVASH NRDGVLGSER VCLCTEGFGN RMCTLENVSD
     KDIPPDIAMC MLYIDNALSM RALQEMMSAD SDHKSASGAG GHKTLLYGHA VQLKHVQSEM
     YLACLSSCSS NDKLAFDVGV QETNEGEACW WTIHPASKQR SEGEKVRVGD DVILVSVATE
     RYLHMAYSKG YMVIASFHQT LWNIQSVSSG SMRTRNMGFL FGNDVLRLFH GNDECLTIPE
     NWSEHPQHNM VIYEGGAAVT QARSLWRVEL IRMKWHGALV GWEQVFRIKH ITSGRYLGVL
     DNSVQLYHKE KADFDLTAFV MCQNKDPKKQ MLDEKEEEGM GNATIRYGET NAFIQHVKTQ
     LWLSYQTTEV TKKGLGKVEE KKAVALKDGH MDDCYTFFMA LEEESKSARV IRKCSSVLNK
     FLKGIDALQL EGNQSTDWTR VDLNEVLKLM EDLIEYFAQP NDEQDFEEKQ NHLRALRSRQ
     DLFQEEGVLN MILDTIDKFS QMEALPDFAG LIGEETHVKW EQISTYLYLL VAAMIKGNHY
     NCAQFASAQR LDWLFGRLSN PQSAEGILDV LYCVLTESPE ALNMINEGHI RSVISLLEKV
     GRDPKVLDVL SSLCEGNGMA VRSSQNLITQ YLLPGKDLLL QTSMRDHVSS MMPNVMLGVV
     EGSALFRKWY FEAEVEHIET MTKQTPYLRI GWANSVGFKP FPGSGDKMGC NGVGDDFYSY
     GFDGKSMYFG GKSRRVGHKL LEKGDVIGCS IDLTIPEIKF SVNGTYMSGS FKKFNIDGYF
     FPVMSLSAKV SCRFILGGNQ GRLRYGPPTG FSAVVEAVNG ELQITDCLSF GDLGKNIFSG
     PQTIFNNLEP FIPTPIDVSA TQLNHHATEM HQKYAENLHE LWAMRKIELG WSYGETRSET
     SRKHPCLTKF EYLPETEKKY NILLALTTMK TIEALGYHLI TEDPPCRLRA VRLGPNFQQQ
     NGYKPGPLDT HEIQLPAELQ PLTEALARNT HNIWAKEKIK RGWTFGLSEH VDATQKRSPH
     LVPYEQVDER IKQANRESAA ENIRALQLFG IFLEPPAHEH DEVAEKELRA RKDNTRTYRA
     EATYAVCGGK WYFEFEILTA GYMKIGWMDI GSTPEIQLGA DDRSYAFDGY LGRKWHQGAE
     TYGKEWKIGD VVGCFLDLND RTISFSLNGE LLLDPSGSEM AFDNVVCGDG LVPAMTLGSG
     QRGRLNFGQQ SNSLKFFTTC GLQEGYEPFC VNMYRTMPMW FAKQLPRFED ISTLKSGSIL
     EVSRIPATGN SPPCLKILQK VTISEGGPSE KAKMEYIKLS LPVKCNDTFV KNKDKETIRR
     QLQEYKPRSQ SVVSQIRAPG IPKEFDDNKE KKGFLRSMLG SKDSHESDDD RRSRTNSKQP
     SVDGDEPPAV SQRRRVLTLM NFGMYSFDES ILTWLHVNEE DNHKWQDVLR RSLLELPHDE
     RQIAEDSMRD LNDRHSEKPK KGGLLSRLRD SSNTRKKDSD RRKEEKAAQL RQMKANSRSF
     DAGSLDTSTL PTGQKDVLEE ETEEQEPIWV MQDQFHDEDT VSASSEMPLS GPGRQLTIKR
     SSIKKNKKGK KAEIALEKME REKKGSIIPM DAQLDVLQEG DAHALVHHKD KVDEYYYGIR
     IFPGQDPSQV WVGWVTTQYH YYNVNFDGSQ GVRKCRFSEA DHHGTTVDSV QSQNCYMVNV
     SELLATTPDV ANTKVSGTLI GCIIDTSIGE LSFQVGSTDT GIKFKLEPGA MLFPAAFVTP
     TATEILQFEL GRIKYTFPLS AAMFKSCEKS LVPFCPPRLT VEQIESVYWA RVPNETLRTT
     ALKLSEVRGW SVLCNDPVRI MSVYIPEKDQ SLDILEMIEM PDMLEFHRQT LNLYCKLASH
     GNHKVAHTLC QHIDEDQIMY AIKSHYLSGP MRQGFHDLLI GLHLMSHTAA RNSMAKEYVI
     PLVPQLQIKN VLDPDSESRY PQITGESVSM LSQMASEPVK KHVSREDEMK LLPPSVDFEA
     LKKHVMESLQ SATHHAVMNC RDLIGGDNTN HFEPLFKLFD QLLVIGLIND EELECLLRLI
     HPQAFDENYE TGTTQKGLTQ LELAEPVKIQ LVSILDHLCD IQLRYRIESL VAFTEGFVGE
     LQSDQCKRYM EIKQTDMPPA EAAKKTKEFR CPPKEQMFRL LMCKVKEERD PELMEEDADV
     DQCPMAEGLQ QQLRDFCELL VGKIGNVKEG DSDDQLALIE SEEGSWVDSF ARIVVKVPPP
     VLEEGMEMQK KGTQNFREII VTMLREWAQA DFIESKSLIR NMFRLLLRQY SGIREIRDAM
     SQTYVFHERN EKDVTDFLVY LIQIRELLTV QFEHTEEAIL KRGLWKLMNN RIFFQHPDLM
     RLLSVHENVM SIMMNILTAQ QGTVEHEGDE LKEKAPIKDA SEMVVACSRF LCYFCRTSRQ
     NQKAMFEHLS FLLDNATMLL ARPSLRGSVP LDVAYSSFMD NNELALALKE EELDKVAVYL
     SRCGLQPNSE LITKGYPDIG WDPVEGERYI DFLRFCVWIN GENVEENANL VIRLLIRRPE
     CLGVALKGEG QGLFSAFKEA IALSEDIRLL ENDSHPSLLS SGLLGENPTY PSKDAEGEDY
     IDLGAATLDF YSSLVDLLAK CAPDPMAIQA GKGDSLRARA ILRSLISLDD LGQILALRFT
     IPNLAAPSIE AVRRANAVQA SHTQKAVMAH TFAMVASLAS EVSNTRRSQT FTSGTNLAKR
     GLPCVEEVDT DDSKSSDYAS VHTSFSSGNE LFAPKAEKEK VDVLKLNENK YPIIQRRRSS
     RFNPIDNTGP LPGLLPNHKG SVLLFLDRVY GIDQQDMLFH VLEQSFLPDL RAATMMDSPR
     ALESDTALAL NRYLCNSVLP LLTNHSHFFA DAEHHSALLD ATLHTVYRMN RLKSLTKNQR
     DAVSDFLVAI TRELPPAMMI KLLKKVITDI LTMNDMNVLV PLRLITLHYE RCGKYYGSGN
     HYGVASEQEK RLSMLLFDAI FDTLGSRPYD PELFGKALPC MTAIGSAISP DYTLTSGLED
     VRNKRREEEG AWIPRTVDVS RCEINRDLEK MTELFAEHFH DSWASRKLEK GWVHGDLYSR
     ANFTHPRLKP FALLKDFEKS FYKERCSECL KALMAWNYSF EMMDRDANDR ASAARTLSGT
     SISNFAPKPI DLSSMTLEKD MVNAAEKMAE HSHLIWAKKV MNDLNTKGGF MPIPLVPWDL
     LTDFERRKDR FRASEILKFL QYHGYHVNCP KDEQSQNDRL KSEGERTSVE KRFAYNLLEK
     LITYLEQASL KMKSVKPSQE LTRRNSFKKE GQDVKFFEKV VLPLMHAYFN AHKNYFLEGS
     SIVQTGTASN KEKEMVANLF CRLAALLRIK NRAFGSVAKI TVKCLQGLTQ ALDLRTLVKV
     NSDIVRTSLL TFFNNCADDL YASVNELKKC IYYSEIEEYD DGGQYSLIRG QALKSWNSFE
     FANQMIVPVL TTMFAHLARN HFGTDLLLDD IQAACYKILD SLYMVTGLSS SISHRKSISG
     ESEKHRPGLG QCLAAFASCF PVAFLEPEFN KSNKFSVLAK SQDQSVQVQE MLQNLSTHIP
     HLEKLLTDLE TVANNNTMYS DVPNVYDVDL PLMCSYMAHW FSVGPDGKRD KEDQRASVVQ
     TTSVSCDHIN RIFNALLKMI RNHVGIENAP WLCRVNFFAV QIIQNVTSDP VREFVLPIAE
     RLRRMSEKAY KEEEHMRTHP DDADEGTVAE DNARLVRDTY AFFPILMKYT DLHRAQWLKT
     PTWETDGVYE NVAVIFRIWS QSQHFKREEL NYVAQFEEDA AATGGGDMKT GKAAIAERKK
     KRREGQDKMK EYFDRNGRPI IKKDKHAASI VIACLKRLLP VGLNVFGGRE LDIVQQSKEK
     FIQKETEEKI REFIKGLLEI PVKTDPTDKN AWQLSLYRKI GKSQMRGKDE MSQDAVIEKI
     FNMGQVSAIL HTITRTKDRR RRAHHRWKYN RKNINIAQVN HSDRNVVLSI SCYVLSHLDG
     ASANATVASM EKSGLDATKT CRCGVFPHGS TVWNSKMTSR MEKEDIWKKV LTLQRKRMAI
     SLITASHLYK TELHRGINFF LPAFSRLWME EEDAGQDQLI ADICSGVEEE EGPRIEIIME
     EGVPIVASSE DTKEKETNPD PLKQLIRCFQ RAATSEETAA SAIHEDSLYI RFADVMAKSI
     HIEEEDGEDG EEGEIDQAAK EEQSQALRGE QAVLASRGAA IMCLMYLSAS GGEPNEMVAQ
     TLQLGIHLLS GGNVEIQKML IEYLQLKKDV RFFTSMAGLM NKCSVLNLEM FERQIKNVDA
     HGANELLLRH LSSKIRHRSR QDRLGAQAEG LGMGAELASG DNQNLNDADF TCSLFRFLQL
     TCEGHNLEFQ NYLRTQPGHT TSVNLINCTV DYLLRLQESV MDFYWHYSSK EVIDEGGKEY
     FLRAIQVCSQ VFNTLTESIQ GPCVGNQMTL ANSRLWDAIN GFFFLFAHMM EKLYKNSTQL
     ELLREFLNLQ KDMIVLMLSM LEGNVLNGSI GKQMVDALVE SQPSVEKILK FSDMFLKLKD
     LTTSQAFQDF DTNQDGWISP KEFQRAMESQ KMYTVEDITY LMMCTDVNND GKVDYMEFTE
     RFHNPARDIG FNLAVLLVNL KEHITNDPRL EKIIEKAQTL LEYFDPFLGR IEIMGSSKRV
     EKIYFEIQES WLEQWGKQQI RDSKNSFLFN VLQDDGGDQG KLEAFINFCE DTIFEMQHAA
     AISSGDSDTK MERAIKQRDY FLQQTSADHI SETFKSGYNY GISAASALSP QNISTTMRNV
     SSSVRQMSWT QLLYAVIILF IRAGLAIGWA GYLLLMTIFR FGYFLTTSSE EEEAARQEKE
     QAKMNNEHPS FNPPIIQEFH HSHVGVTAFG VGMNADHLNV NSLPDFVPPE RPETPETVLE
     EEKPLNQETS PPTSPTSPAS KAPSIYESIG APQMVQLQSE ADFQQGQYEP KIAESNSTKS
     RGSILNMLAR NFKTIEKITL YLAFFINVIL LFHRVDISHA ENAEAASEGD DDEDALESIF
     ITGMQFPYVE YEITGWMLAQ ILYWISVLHL STSFALLVSF YQLKIPLITF KREKEIARKL
     MFDGCWITEE DSEELGIVDT FMWYLDRIVV SAKSFPMMYW DKFVRRKTRS KFKDQVDEET
     LTSILGEEKM STDSSYDYRY SCWLWIGVIL TNGQFLYRVG YLLCSACGVF LSPFFYAFHL
     IDVVLSFPML KAILQSVTHN LQQLILTIMM TLVVVYLYTV IAFNFFRKFY VQEGEEGEEP
     DRKCHNMLTC FIYHFYAGVR AGGGIGDELE SPYGDDLEYP RMFYDISFFF FVIIILLAIM
     QGLIIDAFGE LRDQQESATE KLESSCFICD IGKETFDRMP RGFEIHTTKE HNFANYLFFL
     QHLVNKDETE YTGQETYVRE KYDNRDWDFF PVGECFVKQY EDQLLQS
//
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