ID I2HAJ6_CAEEL Unreviewed; 1725 AA.
AC I2HAJ6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE SubName: Full=Neurexin-3-beta {ECO:0000313|EMBL:CCH63924.1};
GN Name=nrx-1 {ECO:0000313|EMBL:CCH63924.1,
GN ECO:0000313|WormBase:C29A12.4k};
GN ORFNames=C29A12.4 {ECO:0000313|WormBase:C29A12.4k}, CELE_C29A12.4
GN {ECO:0000313|EMBL:CCH63924.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCH63924.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCH63924.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCH63924.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; BX284605; CCH63924.1; -; Genomic_DNA.
DR RefSeq; NP_001263859.1; NM_001276930.1.
DR AlphaFoldDB; I2HAJ6; -.
DR SMR; I2HAJ6; -.
DR STRING; 6239.C29A12.4k.1; -.
DR PaxDb; 6239-C29A12-4k; -.
DR EnsemblMetazoa; C29A12.4k.1; C29A12.4k.1; WBGene00007799.
DR GeneID; 179503; -.
DR KEGG; cel:CELE_C29A12.4; -.
DR AGR; WB:WBGene00007799; -.
DR WormBase; C29A12.4k; CE47593; WBGene00007799; nrx-1.
DR eggNOG; KOG3514; Eukaryota.
DR InParanoid; I2HAJ6; -.
DR OMA; SCHVQSN; -.
DR OrthoDB; 2876893at2759; -.
DR PhylomeDB; I2HAJ6; -.
DR Reactome; R-CEL-6794361; Neurexins and neuroligins.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00007799; Expressed in pharyngeal muscle cell (C elegans) and 3 other cell types or tissues.
DR ExpressionAtlas; I2HAJ6; baseline and differential.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0048786; C:presynaptic active zone; IDA:WormBase.
DR GO; GO:1903910; P:negative regulation of receptor clustering; IMP:WormBase.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00110; LamG; 6.
DR Gene3D; 2.60.120.200; -; 6.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR15036; PIKACHURIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR15036:SF85; SP2353, ISOFORM A; 1.
DR Pfam; PF02210; Laminin_G_2; 6.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00282; LamG; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 6.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50025; LAM_G_DOMAIN; 6.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00122}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1609..1630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..223
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 219..264
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 269..468
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 476..656
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 661..698
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 702..873
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 884..1062
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1065..1102
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1106..1297
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT REGION 1370..1398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1502..1539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1566..1586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1508..1539
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1035..1062
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
SQ SEQUENCE 1725 AA; 192755 MW; 46519C75CCBB5BD2 CRC64;
MRQKFDDTGQ YLTIWLVFTV SLFSVVDSII LTGAPDSYAR YPKWAHSFEN SLSMELKTRQ
SDGMLLYTDD GGTHGNFYSL TIVEGHIQLD FRLGDNSNEF GQRRPVNTIR IEEVRIDDDK
WHTLTIFQSW ENVKLELDYT LVFKILNQRS FVFGNILKNS DVFIGGLPPN MHMLPVMSSP
LRRYARHLAV NVRNLMYRQY PQGVTSPQLL ESVGTRTNED DHCKSKSMSS REQFVCLNDG
ECYSSNDGPH CDCQFSDHDG RNCEIEKNDG ELTFGGDEWV GYDVSLNISA AVRAKKENLT
LTFKTVHGTS MLFYAGDEKS YLHVMLQDGA IIASSKFDGS DARIIRMFNS FPSQRYDDDS
WHTIILERSL QMHSEEMVAI HMTLIVDGRR DEIRQYAPEL DWISNSFGFL GSIPKHNPSK
EVNRVSFRGC MKKVRYDIDA TRILLVNLAD QSYGGSVVKT EGDISYSCKN PSQRSDVLSF
TETSSYLTLP RWNSLSSGSL SFHFRTTSSD GLILYHGVMQ HNATDYVAFE LIDSHLFMII
NLGSGVVRLQ TTSMKVSDGE WHHVQLDRLS RTGSVIVDAI KIDFSTPGVS ANLIIDDPIF
IGNVPNNSLV YPSSVWSIAL QKGYTGCIKN IRMNGVSTKI GQEFEASNST GIELGCSLSN
ELDICEPNPC QNFGKCSKNL NSFDCDCSNT NFEGKQCELE QTAVEVNGEE SKVHVLAHTK
VSQVEHIKIR FRTTSSRGVL FDTGANGKND KITVFLNDSQ LNLFLQDSST NNTFSWGKSL
SDNHWHELQV RRLGQKLLLY LDGFWSHSIY LQNPISVEID EVGAAFSVHS SAPPPRDEHF
KGFLSKLVFN GNDYLAKTKM NSAQLSKSSS RESKGQRNVK TRIASISFTN STGYVAFSSD
KISGLTGSFR VQFKFQTLMR SALLFFTLPK HDYDQSFRLQ MLNGRLKYTY RTSGQEFHTT
SPKLPHRQHL SDMRWHNVLI YQDEKTHDHV LLVDNSSTTL IIDKIKKVES KMSGKLYFGS
NPLGVSRPSN GFRGCISTLR INENALDLYE DADSRMKVNR GCSGPIARCI EDACANHGRC
IQLWSSIRCD CSLTAHSGDR CQNPSTTVRF DGSPSAIFYE YAPNERPTTS KDYFVFSFRT
TQPNGVLISI ECAADQDYFT IFLNKGYLNA HYNLGNRDHT TSYHTRILND GFPHVIKISR
TEANMTIQVD KLPSLRYRPK RASDLVLLNM QTRISIGAAF NTRHLDQKRL LRHRRNTEIF
DSYQGEISGV NVNGLMILDL YENGSNRIHT IGAPQTTAVS EQVSSESEED DELAEMMMAH
SIDENPNEAL IESLAPSCLS LEEQQSCFID TDDSTGFFSP VLPTVANFPT TRQTEPETTR
RPLSPSKMTP SLPSPTTTTL PVFFLSQITD GDESEDEFDG SGDDLFGGDG VGITAATQPS
VKRTTSISVV TKVLTTTSEP SSTHRSTVLP RPYASVKEAA EQNPDYLGAS IWNQVDTLPE
PMVTGPAWRT NKSLTTTATT EASSTKSNRK TTTTTTTSAT TTIRIQQRPN YDIDNEVTAL
ITSSLAPQKT RPKSTPHFTV YPVRPTTPMG DTITTTMQAA TVTDFPRTPL IMCSSLAVII
AIAAVVFFVF KCRQNPPNSE HYTMAMKSQS GYTAIAPELS PPMNHDRSND SCTQPLLAKP
HINGNGYEPL KGAVIANGNG ATATMMRNGN GNGVAKKKDF KEWYV
//
