ID I2J062_9STRE Unreviewed; 575 AA.
AC I2J062;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=Septation ring formation regulator EzrA {ECO:0000256|HAMAP-Rule:MF_00728};
GN Name=ezrA {ECO:0000256|HAMAP-Rule:MF_00728,
GN ECO:0000313|EMBL:EIF36364.1};
GN ORFNames=HMPREF1116_0028 {ECO:0000313|EMBL:EIF36364.1};
OS Streptococcus sp. SK140.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1095726 {ECO:0000313|EMBL:EIF36364.1, ECO:0000313|Proteomes:UP000003237};
RN [1] {ECO:0000313|EMBL:EIF36364.1, ECO:0000313|Proteomes:UP000003237}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK140 {ECO:0000313|EMBL:EIF36364.1,
RC ECO:0000313|Proteomes:UP000003237};
RA Durkin A.S., McCorrison J., Torralba M., Gillis M., Methe B., Sutton G.,
RA Nelson K.E.;
RL Submitted (APR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of FtsZ ring formation; modulates the
CC frequency and position of FtsZ ring formation. Inhibits FtsZ ring
CC formation at polar sites. Interacts either with FtsZ or with one of its
CC binding partners to promote depolymerization. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
CC Single-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_00728}.
CC Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}. Note=Colocalized with FtsZ to the
CC nascent septal site. {ECO:0000256|HAMAP-Rule:MF_00728}.
CC -!- SIMILARITY: Belongs to the EzrA family. {ECO:0000256|HAMAP-
CC Rule:MF_00728}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIF36364.1}.
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DR EMBL; AJML01000040; EIF36364.1; -; Genomic_DNA.
DR RefSeq; WP_001282633.1; NZ_AJML01000040.1.
DR AlphaFoldDB; I2J062; -.
DR PATRIC; fig|1095726.3.peg.1620; -.
DR eggNOG; COG4477; Bacteria.
DR Proteomes; UP000003237; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005940; C:septin ring; IEA:InterPro.
DR GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR GO; GO:0000921; P:septin ring assembly; IEA:InterPro.
DR HAMAP; MF_00728; EzrA; 1.
DR InterPro; IPR010379; EzrA.
DR Pfam; PF06160; EzrA; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell division {ECO:0000256|HAMAP-Rule:MF_00728};
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_00728};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_00728};
KW Septation {ECO:0000256|ARBA:ARBA00023210, ECO:0000256|HAMAP-Rule:MF_00728};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_00728};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_00728}.
FT TOPO_DOM 1..8
FT /note="Extracellular"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TOPO_DOM 28..575
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 111..138
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
FT COILED 262..416
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00728"
SQ SEQUENCE 575 AA; 66410 MW; D57122DE121E25B4 CRC64;
MSDNLLIITM IAIAALLIIA YVVAVLLRKR NEKRLAVLEE RKEELYNLPV NDEVEAVKNM
HLIGQSQIAF REWNQKWVDL SLNSFADIEN NLFEAEGYNN SFRFLKAQHK IDQIESQITL
IEEDIASIRN ALADLEKQES KNSGRVLHAL DLFESLQKSV VEDSEKYGQA LLEIEKQIEN
IQSEFSQFVT LNSSGDPVEA AGILDNAENH ILALTHIVER IPAIVTKLTT ELPDQLEDLE
AGYRKLLDAN YHFVETDIES RLQLLYEALK NNQENIKKLE LDNAEYENNQ IQEEINALYN
IFTREIASQK VVENLLSTLP TYLDHLKDNN QVLVKDIERL SKTYLMAESD VNHVRRLQVD
LDSLELTVSD LTSEQEEYSE AYSVLEERLE NVQATLKEIE DDQVSVSERL VQIEKDDVNA
RQKANVYVNR LHTIKRYMEK RNLPGIPQNF LKLFFAASHS TEDLMAELEQ SQVNIESVNR
ILEIASHDME VLETETYSIV QYATLTEQLL QYSNRYRSFD EGIQQAFHES LEIFENAFDY
QASFEKISQA LEVAEPGVTN RFVSSYEKTR EIIRF
//
