ID I2JJG8_9GAMM Unreviewed; 1122 AA.
AC I2JJG8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE SubName: Full=Mechanosensitive ion channel MscS {ECO:0000313|EMBL:EIF43120.1};
GN ORFNames=DOK_09651 {ECO:0000313|EMBL:EIF43120.1};
OS gamma proteobacterium BDW918.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Spongiibacteraceae.
OX NCBI_TaxID=1168065 {ECO:0000313|EMBL:EIF43120.1, ECO:0000313|Proteomes:UP000003473};
RN [1] {ECO:0000313|EMBL:EIF43120.1, ECO:0000313|Proteomes:UP000003473}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BDW918 {ECO:0000313|EMBL:EIF43120.1,
RC ECO:0000313|Proteomes:UP000003473};
RX PubMed=22740675; DOI=10.1128/JB.00678-12;
RA Kim S.M., Cho S.J., Lee S.B.;
RT "Genome Sequence of the Unclassified Marine Gammaproteobacterium BDW918.";
RL J. Bacteriol. 194:3753-3754(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIF43120.1}.
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DR EMBL; AJMK01000038; EIF43120.1; -; Genomic_DNA.
DR AlphaFoldDB; I2JJG8; -.
DR PATRIC; fig|1168065.3.peg.2027; -.
DR eggNOG; COG3264; Bacteria.
DR HOGENOM; CLU_007829_2_0_6; -.
DR OrthoDB; 9799209at2; -.
DR Proteomes; UP000003473; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049142; MS_channel_1st.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR InterPro; IPR011014; MscS_channel_TM-2.
DR InterPro; IPR025692; MscS_IM_dom1.
DR InterPro; IPR024393; MscS_porin.
DR PANTHER; PTHR30347:SF1; MINICONDUCTANCE MECHANOSENSITIVE CHANNEL MSCM; 1.
DR PANTHER; PTHR30347; POTASSIUM CHANNEL RELATED; 1.
DR Pfam; PF21088; MS_channel_1st; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR Pfam; PF12795; MscS_porin; 1.
DR Pfam; PF12794; MscS_TM; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF82861; Mechanosensitive channel protein MscS (YggB), transmembrane region; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000003473};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 561..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 638..656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 668..693
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 705..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 738..761
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 815..841
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 861..881
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 902..927
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 933..963
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 81..300
FT /note="Mechanosensitive ion channel MscS porin"
FT /evidence="ECO:0000259|Pfam:PF12795"
FT DOMAIN 521..848
FT /note="Mechanosensitive ion channel inner membrane"
FT /evidence="ECO:0000259|Pfam:PF12794"
FT DOMAIN 908..949
FT /note="Mechanosensitive ion channel transmembrane helices
FT 2/3"
FT /evidence="ECO:0000259|Pfam:PF21088"
FT DOMAIN 951..1016
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 1026..1107
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
FT COILED 264..341
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1122 AA; 126051 MW; A121F4189A900257 CRC64;
MLYCQRNHIP KKNSPPPTRA YFAYSPANST NTPSASPTQL TVKIYRYALF VFCFLLSIAA
WPSYAASTNT QQTISDLQLR LNAAQSSEKL NSEQRDFIVQ LYQQALDNLA QATEDRNQAQ
GYIDQIATAA TRQAEIQQKL DQALPEVDVG GKLSLLEKRL LNQQATLLEL HSEETAINAR
IVTAQQDVSP LIEAALQKQS NAEAQLAESP ESQTTELAKA RRAFNESESV AANARVELLR
QRLISRDSRL EILDLQQRLV VRKIDIANQA IEKLQEAVSS ARRNQANAIA EQAQQRLVEL
ENADEEIKKI AQDNAELASD IANITARTDD LLNKLAQLRD ERSYVERYSN SMAQQLAITG
ADRLSTLGVD LLEQRQQFFQ RSSLTLKTKI LDEELARAQL TKLRLEDRQY LITKENNTGL
DSQGDKLRDE QGLLLQSGIK IYRRYIETIM TTRSENIALK TKTAEYMTLL NSRLLWIPST
TPLWTQLKQA IEQETPWSER LSAWRANTPS KSLQWSNKWQ LFLLAIPGLI ILLKPRLLSL
LKTLATNVGK VNRDRFSDTA LALFISLLLA SPGPLALGFL AALTSDGGAL TEQIHQGLKN
AAGLWLLLNV FREICRPDGV AEFHFKWRLD IINVTRKNLR WLTLTLVFVS LFIPIADHPA
DGNSIISRLL FSVSSLALAY VTHRVLWQLF LLRNHAPRRQ ISFKYIIHAL AVCIPLVLLG
LSWYGYHFSA LMIQNKLFVT ACLMAALFIL YSLILRIFSV VERRMTLERL RVKRKAEQAQ
NANRQAADNA GEGMPESIDA TEYDMDTITQ QTRGFLGLLT GVAAIVLGWE LWAEILPALS
ILNNIELWHV TGANPAMGDK AITLADGIIA IIMMTLTYLG ARNLPGILEI SILRKLQLEA
GSSYAITTVV KYIIVMVGII VSLNIIGAQW SKLQWLVAAL GVGLGFGLQE IVANFVSGLL
ILFERPIRVG DTVTVGNHTG TVTRIRIRAT TLTDWDRKEQ IIPNKTFITE QLTNWTLSDS
ITRQIIKVGV AYGSDVIAVH KLLSKVIEDN RRITKDPPPS VFFVGFGDSS LNFELRVFVP
SMLDIMPLIH EIHVEIEATL RKHEIEIPFP QRDIWIRSEG EQ
//
