ID I3E0D9_BACMT Unreviewed; 734 AA.
AC I3E0D9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=PB1_06342 {ECO:0000313|EMBL:EIJ79960.1};
OS Bacillus methanolicus PB1.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=997296 {ECO:0000313|EMBL:EIJ79960.1, ECO:0000313|Proteomes:UP000010523};
RN [1] {ECO:0000313|EMBL:EIJ79960.1, ECO:0000313|Proteomes:UP000010523}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB1 {ECO:0000313|EMBL:EIJ79960.1,
RC ECO:0000313|Proteomes:UP000010523};
RX PubMed=22610424; DOI=10.1128/AEM.00703-12;
RA Heggeset T.M., Krog A., Balzer S., Wentzel A., Ellingsen T.E.,
RA Brautaset T.;
RT "Genome Sequence of Thermotolerant Bacillus methanolicus: Features and
RT Regulation Related to Methylotrophy and Production of L-Lysine and L-
RT Glutamate from Methanol.";
RL Appl. Environ. Microbiol. 78:5170-5181(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIJ79960.1}.
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DR EMBL; AFEU01000002; EIJ79960.1; -; Genomic_DNA.
DR RefSeq; WP_003351366.1; NZ_AFEU01000002.1.
DR AlphaFoldDB; I3E0D9; -.
DR STRING; 997296.PB1_06342; -.
DR PATRIC; fig|997296.3.peg.1351; -.
DR eggNOG; COG4191; Bacteria.
DR eggNOG; COG4585; Bacteria.
DR OrthoDB; 9781904at2; -.
DR Proteomes; UP000010523; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR CDD; cd00130; PAS; 3.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 3.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR000700; PAS-assoc_C.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR NCBIfam; TIGR00229; sensory_box; 3.
DR PANTHER; PTHR43304:SF1; PAC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43304; PHYTOCHROME-LIKE PROTEIN CPH1; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR Pfam; PF08447; PAS_3; 2.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00086; PAC; 3.
DR SMART; SM00091; PAS; 3.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 3.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50113; PAC; 3.
DR PROSITE; PS50112; PAS; 3.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EIJ79960.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 10..80
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 83..135
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 129..202
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 205..257
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 258..328
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 331..382
FT /note="PAC"
FT /evidence="ECO:0000259|PROSITE:PS50113"
FT DOMAIN 632..722
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 373..400
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 734 AA; 84954 MW; 995F7BFC5DCD5A7B CRC64;
MNYDHDVINE DEKYKIVAEN TSDIIVLVDN EAIVRYVSPS FQQTLGYTIK EYEGMDAFDI
IPPEDRDRVR SSHFQAIQTK TPVVLEYRLI HSQGSIIHVE ARVKPVLDRD GNVKYVVAVV
RDITERKKTE QLLENILESV NAAVWSTEKD FSYYTFCSES IEKISGIPRR EIMFKPIRLH
DHIHPDDNEM LMGEVKNSLD RGIPVNKVIR FIHVEGETRW GRLIVHPYMD NTGTIERFDG
IILDITELKR SELALEESEQ RYKSLFENNL DGVFSIDLNG YFVNANQAFE KITGIKIDQL
PDRCFIGLIY DEDHMSVYHI LSEVMKKQEP RDVECRIIRS GYGEKIVNIT FVPIFLSGEL
NGVHGIVKDI TERKREEMEL IQSEERYKSL QQSINRFSND LANVMKVTEL ENRLIEEVKK
VLPVNSVSIE ELPRGHESVL RNMNEIWIKI AEKEQPVYLR IEINQSLLKI EEEWLETAVH
YVTILYDNLQ LIEDLMKRLE DMVTNNQTPK WMLKLLFKLS EKERALLSSD LHDSVLQDLI
IWYRKLESLR SSTSFSEETH GKLIQIEEGL LDAIHQIRIT CNELRPPFLL KMGLVESLKS
LFSYARMFSN YEIEFSSMNL ENPLHEDQIL GIYRIVQELL NNASKHSKAS KVTMKLTGYE
EHIHFSYSDN GVGMDLSVFE GSFKHMGIAG IKNRVLSLEG EVEIKSAPQE GFHVNIIVPT
TTPQKGDHYG NIIG
//
