ID   I3EES7_NEMP3            Unreviewed;       471 AA.
AC   I3EES7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 35.
DE   RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN   ORFNames=NEQG_02271 {ECO:0000313|EMBL:EIJ87724.1};
OS   Nematocida parisii (strain ERTm3) (Nematode killer fungus).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nematocida.
OX   NCBI_TaxID=935791 {ECO:0000313|EMBL:EIJ87724.1, ECO:0000313|Proteomes:UP000002872};
RN   [1] {ECO:0000313|EMBL:EIJ87724.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ERTm3 {ECO:0000313|EMBL:EIJ87724.1};
RG   The Broad Institute Genome Sequencing Platform;
RG   The Broad Institute Genome Sequencing Center for Infectious Disease;
RA   Cuomo C., Troemel E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M.,
RA   Haas B., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.,
RA   Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA   Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA   Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA   Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Nematocida parisii strain ERTm3.";
RL   Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; GL870881; EIJ87724.1; -; Genomic_DNA.
DR   AlphaFoldDB; I3EES7; -.
DR   STRING; 935791.I3EES7; -.
DR   EnsemblFungi; EIJ87724; EIJ87724; NEQG_02271.
DR   VEuPathDB; MicrosporidiaDB:NEQG_02271; -.
DR   HOGENOM; CLU_580162_0_0_1; -.
DR   InParanoid; I3EES7; -.
DR   OMA; ESIINMT; -.
DR   Proteomes; UP000002872; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IEA:InterPro.
DR   Gene3D; 1.10.150.80; HRDC domain; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR045092; Rrp6-like.
DR   PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR   PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SUPFAM; SSF47819; HRDC-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002872}.
FT   DOMAIN          383..463
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
SQ   SEQUENCE   471 AA;  54132 MW;  76F6144D33526ACB CRC64;
     MLLPQATERL SKALTKYTNM IKQEKLIMTE AEISSKLHQC QELIGQVENQ ISTEPLSLLK
     TIEDILEDIH KTCTNTENVK EENIIPDPTT ILIESATKKK FVLSKNIPRP QINFKNRDVY
     AMKPEGFYHS NSFIRTAQSA KTPAETVEVD SQTVEGCENI EDATRSILMK LYSSTKIIDV
     TTEISPNIYY IKTAEECKMA NTHILQEAAV GVDIKTHKFR SYSGFTCYIQ VATLESIYLF
     DMIELRNNSE LLTFWSNPSV VKVFYKATEK VYWLKKDLQY TVKAYVDLLS IYGYPEEVTN
     LGRAVMYATG RKLRKQLQLM DWRYKPISVE MCTDLTEQVG YLLLSVAGMA KKCTEEQFVS
     GYNYKAKKIE SDLSPEEFLL SKNIEPAEIS VKLHMLRDFI AKQEDESPQF LMTDKQLVRF
     IKEQPTTQEQ VFSLFKNISP LFKANLNNFI NLLHSTHKTS SFNMTALKDK S
//