ID I3EFV2_NEMP3 Unreviewed; 694 AA.
AC I3EFV2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Eukaryotic translation initiation factor 5B {ECO:0000256|ARBA:ARBA00013824};
DE AltName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00032478};
GN ORFNames=NEQG_01543 {ECO:0000313|EMBL:EIJ88099.1};
OS Nematocida parisii (strain ERTm3) (Nematode killer fungus).
OC Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Nematocida.
OX NCBI_TaxID=935791 {ECO:0000313|EMBL:EIJ88099.1, ECO:0000313|Proteomes:UP000002872};
RN [1] {ECO:0000313|EMBL:EIJ88099.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ERTm3 {ECO:0000313|EMBL:EIJ88099.1};
RG The Broad Institute Genome Sequencing Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Cuomo C., Troemel E., Young S.K., Zeng Q., Gargeya S., Fitzgerald M.,
RA Haas B., Abouelleil A., Alvarado L., Arachchi H.M., Berlin A.,
RA Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P., McCowen C.,
RA Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M., Roberts A.,
RA Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Nematocida parisii strain ERTm3.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GL870879; EIJ88099.1; -; Genomic_DNA.
DR AlphaFoldDB; I3EFV2; -.
DR STRING; 935791.I3EFV2; -.
DR EnsemblFungi; EIJ88099; EIJ88099; NEQG_01543.
DR VEuPathDB; MicrosporidiaDB:NEQG_01543; -.
DR HOGENOM; CLU_002656_3_3_1; -.
DR InParanoid; I3EFV2; -.
DR OMA; FRQSKPA; -.
DR Proteomes; UP000002872; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd03703; aeIF5B_II; 1.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR029459; EFTU-type.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF4; EUKARYOTIC TRANSLATION INITIATION FACTOR 5B; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF14578; GTP_EFTU_D4; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000313|EMBL:EIJ88099.1};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917};
KW Reference proteome {ECO:0000313|Proteomes:UP000002872}.
FT DOMAIN 94..302
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
FT REGION 28..47
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..46
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 694 AA; 77388 MW; 81140CF66E0034EF CRC64;
MAKKKGGKKG YEDIEDMYDM YTEMNNEYTE EVQEEVSEEL SQDVQEEVST EYDHALEQQK
VLASKLERLT MQRPVQKVKK EVKIETEKEM ETDYRSPICC ILGHADTGKT KILDKIRETD
VQLAEAGGIT QQIGATYIPI KELMKKYNIT SEKLPGLLVI DTPGHEAFSN LRSRGSSMCN
IVVLVIDIMH GLELQTKESI ELLRSRKTPF IIALNKIDRI NGWKSSDTPF SIKSQSKAAK
LEFKDRYEKI VLELANTGLN SALFIKNPNP KAYVNIVPTS AVTGEGISDM LSVLLDLVEK
NLLKRVKFEE AVECMVLESR AEEGKGATID VILSNGTVHV GDKIVVCTQN GAVQTVIRHL
LTPNPMKETR VKSKYRENKS VKAAIGVRIS AHKLEGVLAG SKVVVVKNDS DTDRIIEEAD
EQIRETIQAF ISGDKQTTSG TIFDVVGEDG IHAQASTLGA LEALISILKK ANIPIRTVGV
GNISKKDVIK VSTISERHPE YSVMLCFDVA PSQEMQALGK EMKVKFLTAE IIYHLTEKYK
KHMEEQWALA EEQLKDKVIF PCILTIVPGC IFTKRSPLVL GVKVQQGILR IGTPLAVVRD
GEITRIGQVT SILEDTKTNP KNDKIRVGSK ASIKVEVTGN QQPIIVGRKL FETDQIISRL
TRESIDFLKE SFKDALTKED WLTVIKLKGI LGIH
//
