ID   I3IUR8_ORENI            Unreviewed;       667 AA.
AC   I3IUR8;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=TOX high mobility group box family member 4 {ECO:0000313|Ensembl:ENSONIP00000000358.1};
GN   Name=tox4 {ECO:0000313|Ensembl:ENSONIP00000000358.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000000358.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000000358.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   RefSeq; XP_003458812.1; XM_003458764.4.
DR   AlphaFoldDB; I3IUR8; -.
DR   STRING; 8128.ENSONIP00000000358; -.
DR   Ensembl; ENSONIT00000000357.2; ENSONIP00000000358.1; ENSONIG00000000284.2.
DR   GeneID; 100692575; -.
DR   KEGG; onl:100692575; -.
DR   CTD; 100003353; -.
DR   eggNOG; KOG0381; Eukaryota.
DR   GeneTree; ENSGT00940000154888; -.
DR   HOGENOM; CLU_030650_0_0_1; -.
DR   InParanoid; I3IUR8; -.
DR   OMA; DGTGPHD; -.
DR   OrthoDB; 4252846at2759; -.
DR   TreeFam; TF106481; -.
DR   Proteomes; UP000005207; Linkage group LG3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   CDD; cd21995; HMG-box_TOX-like; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   PANTHER; PTHR45781; AGAP000281-PA; 1.
DR   PANTHER; PTHR45781:SF6; TOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 4; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          301..369
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DNA_BIND        301..369
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          209..236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          474..550
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..233
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..282
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        476..495
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   667 AA;  69091 MW;  DF8AE10E1E4D1E8F CRC64;
     MDLNFYSDLT DGTGQHDGDP EFLDPQSFNG FDSDNKFPGG SDNYLTIPGS GHPFLSSSET
     FHTPSLGDEE FEIPPISLDP DSALSVSDVV SHFGELSETG PSDSVVVPGN AVVEGDDPSF
     ASTFVSAASQ GLEHLTLGVM TQPGGNTLLG SSLGMDLGHP IGSQFSSSSP VTIDVPLGDM
     GQGLLGSNQL TTIDQSELSA QLGLGLGGGN ILQRPQSPEN PLSATASPTS SLQDDDMDDF
     RRSVLVESPV SLAVSPGVIS LDPSPSQSPL SAPTSSVSSA TGRKGAGGGK KGKKKKDPNE
     PQKPVSAYAL FFRDTQAAIK GQNPNATFGE VSKIVASMWD SLGEEQKQVY KRKNEAAKKD
     YLKALAEYRA SLISQAPIEV METTPSPPPP APAPVVTATP TPIPAPTPPT RPTRSQHYNP
     EENTITNICT SNIILDLPQV TTRSRTGAIK PQPPPASTAL NTAPVAKIII KQTPLPSGGM
     SATVTTASSP RQPPPLQQMQ STPPPPRLQQ MVHAQAPPPL QAKPRGGGGG AAAATTAPPP
     LKVVPSARQS DSSASIIVTS SGETSTTVSA ATSALAVEVG HTGEVTGGEE VVEGEEGMEV
     EVNVAPGPSV TPAASPNICV RAGCTNPAVE SKDWDKEYCS NECVATHCRD VFMAWCAIRG
     QNSTTVT
//