ID I3IW06_ORENI Unreviewed; 1288 AA.
AC I3IW06;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 08-NOV-2023, entry version 61.
DE SubName: Full=Rho guanine nucleotide exchange factor 10 like {ECO:0000313|Ensembl:ENSONIP00000000796.2};
GN Name=arhgef10l {ECO:0000313|Ensembl:ENSONIP00000000796.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000000796.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000000796.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR RefSeq; XP_013128315.1; XM_013272861.2.
DR STRING; 8128.ENSONIP00000000796; -.
DR Ensembl; ENSONIT00000000795.2; ENSONIP00000000796.2; ENSONIG00000000627.2.
DR GeneID; 100701736; -.
DR CTD; 799435; -.
DR eggNOG; KOG3522; Eukaryota.
DR GeneTree; ENSGT00940000153798; -.
DR InParanoid; I3IW06; -.
DR OMA; HIVLWEM; -.
DR OrthoDB; 2916834at2759; -.
DR TreeFam; TF331430; -.
DR Proteomes; UP000005207; Linkage group LG5.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF16; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 333..520
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1134..1174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 503..530
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 13..33
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 212..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1149..1169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1288 AA; 141327 MW; AC93617FFD28B5C9 CRC64;
MSTVVSQQLL KQDGEDDDEE QGEEFEFDDS TDEDKLQEDS KTIIDCVKPV QASKHEDNVT
SGSISQTFTD STRLPTASPS AGPDSVATKD PASVSTTDVP VTESPNCASE AEADEPSASV
PCVGQELQGF PVAPSAVESP VDSGDHSKET VKQGSRGIPE AEPPTAEASE VIYDDVPSEE
PLSPDEDMIY EDVQRDTGAL EAGNGWSSSE FESYDEHSDN EAKLPTKSKL SPEVRRLRER
CARTKRELAM RLSGKHNYDI KVQQLMKAAR SGTKDGLERT KIAVMRKVSF LQRKDQLEEE
DDAGYLDVAV SEVKHPPPQL SPMPEGLTSH QVVRRHILGS IIQSERSYLE SLRRILQEYH
RPLMEADPRI LSPRKIRPIF YRIREITQCH SMFQIALASR VAEWDSTEKI GDLFVASFSK
SMVLDVYSDY VNNFTNAMAL IKKACMSKPA FLEFLKKKQA SSVDRITLYG LMVKPIQRFP
QFILLLQDML KNTPKGHVDR LPLQLALTEL EVLAEKLNEQ KRVADQIAET QQLARSVSDR
LLSKQLNSEQ GSLVLCETLI ETVYGERGQV LKSKERKVFL FDDVLICANI NVKGPPDISS
LVPVGPKYTI KWSAPLQQVQ VVEVGQEGSQ SKDTLFQQSG AKRPSGTFTS GRAILGPPRL
YQELQELQHD LSVVEEVTLL VGTLEGTYQN LNTTVAQDWC LALQRLIRIK EEQIQSANKC
RLRLQVPGRP DKSGRPVSFM VVFNTPNPLS KISWVNRLHL AKIALREENS PGWLCGEDEG
KTTAPFWYPL LACHMSVFAT KSTERKLEAA LHNPVHCALL GFSAASTSLP QGYLWVAGGA
EGSQGQIEIF SLNRPMPRAV KSLQVDSPVR CLEYVPLPSP TDEVESGVPK TPSAIGSNIC
VGLDDGRVLV YGSVDTAAQC LLTLHNPEGC PVLCLKHSSR FLFAGLRNGT MMVYGRNNSD
DLWDPKSHRC VSLGTEPVRT LLVLDDSVWA SCGNSVTVVE ISSFNTQKFE VHPDPRVSVA
HMACAGGGVW MAFSEGSSIR LFHTETLELL QEINISTRST FQTTGQKSMR VTSLLICQGL
LWVGTAQGLI ITLPVSKLEG IPKITGKGMI SLNAHCGPVD FLAATASSLS PELLKRDSVG
DSPDSACGGE DRSDNSSQES LQPSSSYQGE GRGKGRGVLL QYKLRSTSGL PGRPLTALGD
EASDSSLESL EHSVEDGSIY ELSDDPEMWV RGRTCERDGG RRDRVISAAV ISGGKGFRRL
KEGAAAGTRT SGEGLENILM VWQLPLTV
//