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Database: UniProt
Entry: I3IW06_ORENI
LinkDB: I3IW06_ORENI
Original site: I3IW06_ORENI 
ID   I3IW06_ORENI            Unreviewed;      1288 AA.
AC   I3IW06;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   08-NOV-2023, entry version 61.
DE   SubName: Full=Rho guanine nucleotide exchange factor 10 like {ECO:0000313|Ensembl:ENSONIP00000000796.2};
GN   Name=arhgef10l {ECO:0000313|Ensembl:ENSONIP00000000796.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000000796.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000000796.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   RefSeq; XP_013128315.1; XM_013272861.2.
DR   STRING; 8128.ENSONIP00000000796; -.
DR   Ensembl; ENSONIT00000000795.2; ENSONIP00000000796.2; ENSONIG00000000627.2.
DR   GeneID; 100701736; -.
DR   CTD; 799435; -.
DR   eggNOG; KOG3522; Eukaryota.
DR   GeneTree; ENSGT00940000153798; -.
DR   InParanoid; I3IW06; -.
DR   OMA; HIVLWEM; -.
DR   OrthoDB; 2916834at2759; -.
DR   TreeFam; TF331430; -.
DR   Proteomes; UP000005207; Linkage group LG5.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR12877:SF16; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 10-LIKE PROTEIN; 1.
DR   Pfam; PF19057; PH_19; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF19056; WD40_2; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          333..520
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   REGION          1..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1134..1174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          503..530
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        13..33
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        54..104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        212..231
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1149..1169
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1288 AA;  141327 MW;  AC93617FFD28B5C9 CRC64;
     MSTVVSQQLL KQDGEDDDEE QGEEFEFDDS TDEDKLQEDS KTIIDCVKPV QASKHEDNVT
     SGSISQTFTD STRLPTASPS AGPDSVATKD PASVSTTDVP VTESPNCASE AEADEPSASV
     PCVGQELQGF PVAPSAVESP VDSGDHSKET VKQGSRGIPE AEPPTAEASE VIYDDVPSEE
     PLSPDEDMIY EDVQRDTGAL EAGNGWSSSE FESYDEHSDN EAKLPTKSKL SPEVRRLRER
     CARTKRELAM RLSGKHNYDI KVQQLMKAAR SGTKDGLERT KIAVMRKVSF LQRKDQLEEE
     DDAGYLDVAV SEVKHPPPQL SPMPEGLTSH QVVRRHILGS IIQSERSYLE SLRRILQEYH
     RPLMEADPRI LSPRKIRPIF YRIREITQCH SMFQIALASR VAEWDSTEKI GDLFVASFSK
     SMVLDVYSDY VNNFTNAMAL IKKACMSKPA FLEFLKKKQA SSVDRITLYG LMVKPIQRFP
     QFILLLQDML KNTPKGHVDR LPLQLALTEL EVLAEKLNEQ KRVADQIAET QQLARSVSDR
     LLSKQLNSEQ GSLVLCETLI ETVYGERGQV LKSKERKVFL FDDVLICANI NVKGPPDISS
     LVPVGPKYTI KWSAPLQQVQ VVEVGQEGSQ SKDTLFQQSG AKRPSGTFTS GRAILGPPRL
     YQELQELQHD LSVVEEVTLL VGTLEGTYQN LNTTVAQDWC LALQRLIRIK EEQIQSANKC
     RLRLQVPGRP DKSGRPVSFM VVFNTPNPLS KISWVNRLHL AKIALREENS PGWLCGEDEG
     KTTAPFWYPL LACHMSVFAT KSTERKLEAA LHNPVHCALL GFSAASTSLP QGYLWVAGGA
     EGSQGQIEIF SLNRPMPRAV KSLQVDSPVR CLEYVPLPSP TDEVESGVPK TPSAIGSNIC
     VGLDDGRVLV YGSVDTAAQC LLTLHNPEGC PVLCLKHSSR FLFAGLRNGT MMVYGRNNSD
     DLWDPKSHRC VSLGTEPVRT LLVLDDSVWA SCGNSVTVVE ISSFNTQKFE VHPDPRVSVA
     HMACAGGGVW MAFSEGSSIR LFHTETLELL QEINISTRST FQTTGQKSMR VTSLLICQGL
     LWVGTAQGLI ITLPVSKLEG IPKITGKGMI SLNAHCGPVD FLAATASSLS PELLKRDSVG
     DSPDSACGGE DRSDNSSQES LQPSSSYQGE GRGKGRGVLL QYKLRSTSGL PGRPLTALGD
     EASDSSLESL EHSVEDGSIY ELSDDPEMWV RGRTCERDGG RRDRVISAAV ISGGKGFRRL
     KEGAAAGTRT SGEGLENILM VWQLPLTV
//
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